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Analysis of the function of Drosophila cyclin E isoforms and identification of interactorsCrack, Donna. January 2002 (has links) (PDF)
"August 2002." Bibliography: p. 157-169. Analysis of the expression of Drosophilia cyclin EII through development show that it was present during larval development and oogenesis, implying a role for DmcycEII outside of early embyogenesis. Ectopic expression analyses using full-length DmcycE proteins as well as N- and C-terminal deletions of DmcycEI, revealed that DmcycEII and N-terminal deletions were able to drive all G1 cells within the morphogenetic furrow of the eye imaginal disc into S phase, while a C-terminal deletion of DmcycEI could not. These results show the DmcycEII is more potent than DmcycEI in driving cells into S phase and that the N-terminal region of DmcycEI contains a negative regulatory domean., suggesting that an inhibitor is present in the posterior morphogenetic furrow that binds to DmcycEI N-terminus and inhibits DmcycEI function. To identify the DmcycEI specific inhibitor, genetic interaction and yeast-2 hybrid screens were undertaken, and an enhancer CG7394, encoding a MAGUK homologue was identified for further study.
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Analysis of the function of Drosophila cyclin E isoforms and identification of interactors / Donna Crack.Crack, Donna January 2002 (has links)
"August 2002." / Bibliography: p. 157-169. / xi, 169 p. : ill. (some col.), plates (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Analysis of the expression of Drosophilia cyclin EII through development show that it was present during larval development and oogenesis, implying a role for DmcycEII outside of early embyogenesis. Ectopic expression analyses using full-length DmcycE proteins as well as N- and C-terminal deletions of DmcycEI, revealed that DmcycEII and N-terminal deletions were able to drive all G1 cells within the morphogenetic furrow of the eye imaginal disc into S phase, while a C-terminal deletion of DmcycEI could not. These results show the DmcycEII is more potent than DmcycEI in driving cells into S phase and that the N-terminal region of DmcycEI contains a negative regulatory domean., suggesting that an inhibitor is present in the posterior morphogenetic furrow that binds to DmcycEI N-terminus and inhibits DmcycEI function. To identify the DmcycEI specific inhibitor, genetic interaction and yeast-2 hybrid screens were undertaken, and an enhancer CG7394, encoding a MAGUK homologue was identified for further study. / Thesis (Ph.D.)--University of Adelaide, Dept. of Molecular Biosciences, 2002
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The functional roles of cyclin-dependent kinase 5 in neural development /Fu, Wing Yu. January 2002 (has links)
Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2002. / Includes bibliographical references (leaves 154-172). Also available in electronic version. Access restricted to campus users.
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Identification of Pctaire1 as a p35-interacting protein and a novel substrate for Cdk5 /Cheng, Kai. January 2003 (has links)
Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003. / Includes bibliographical references (leaves 153-177). Also available in electronic version. Access restricted to campus users.
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Identification of novel G1 to S phase regulators in Drosophila / by Julie Secombe.Secombe, Julie January 1999 (has links)
Bibliography: p. 143-160. / 160 p., [66] leaves, [30] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Focusses on identifying genes involved in the regulation of Cyclin E transcription or function during Drosophila development. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 1999
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Identification of novel G1 to S phase regulators in Drosophila / by Julie Secombe.Secombe, Julie January 1999 (has links)
Bibliography: p. 143-160. / 160 p., [66] leaves, [30] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Focusses on identifying genes involved in the regulation of Cyclin E transcription or function during Drosophila development. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 1999
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Synthesis of ring-constrained thiazolylpyrimidines : inhibitors of cyclin-dependent kinases /McIntyre, Neil A. January 2007 (has links)
Thesis (Ph.D.) - University of St Andrews, January 2007. / Restricted until 30th January 2010.
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Cell-cycle regulation by Cdk1 in Saccharomyces cerevisiae /Ubersax, Jeffrey A. January 2004 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2004. / Bibliography: leaves 141-150. Also available online.
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The functions and proteolysis of cyclin A and cyclin F during mitosis /Fung, Tsz Kan. January 2006 (has links)
Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2006. / Includes bibliographical references (leaves 197-228). Also available in electronic version.
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Evaluation of the chicken cyclin-dependent kinase inhibitor 1B, p27(Kip1) in MDV-induced transformationKim, Sungwon. January 2007 (has links)
Thesis (M.S.)--University of Delaware, 2007. / Principal faculty advisor: Marlene G. Emara, Dept. of Animal & Food Sciences. Includes bibliographical references.
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