<p>  </p> <p>This research evaluates Kidney Health Initiative's (KHI)   four kidney replacement therapy (KRT) technology priority groups in the roadmap:</p> <p>1) Literature review of technology citations for each of the four KHI priority groups for safety and efficacy data with a patient centered focus. Additionally, the incorporation and integration of KHI minimum technical design criteria in six areas into the development process.</p> <p>2) Clinical PICO analysis of the critical clinical outcomes that the discovery and innovation from the specific technology priority group addresses</p> <p>3) Critical evaluation of KRT technologies on patients with ESKD by expert clinicians and scientists in KRT through Delphi method with targeted questionnaires</p>