Made available in DSpace on 2015-04-14T13:30:38Z (GMT). No. of bitstreams: 1 463068.pdf: 2847170 bytes, checksum: 24881d931a22a088ffe1f361a64aed3c (MD5) Previous issue date: 2014-11-17 / The aim of this study was to make a comparative analysis of aspects related to the osseointegration of titanium implants placed with and without local application of a bisphosphonate, after 4 weeks, in vivo. The study comprised the placement of 50 cp. titanium implants in the middle third of the tibia of 10 rabbits, with the right tibia being used as control, and the left as test site. In the test group, local administration of sodium alendronate gel was instituted, and in the control group, sterile saline solution was used. After euthanasia, 10 implants from each group were analyzed for maximum removal torque. The remainder of the sample was processed to obtain non decalcified slides with approximately 30μm thick, in which histomorphological and histomorphometric analyses of bone-implant contact (%BIC) were performed. Data were analyzed at a level of significance of 5%. The removal torque of the test group, on an average, were half of the values obtained in the control group. The test group showed lower percentage of BIC, and notable changes in bone quality. It was concluded that the initial events of osseointegration of titanium implants are not favored by the local application of sodium alendronate gel in rabbits. / O objetivo deste estudo foi analisar, comparativamente, aspectos relacionados ? osseointegra??o de implantes de tit?nio, instalados com e sem a aplica??o t?pica de um bisfosfonato, ap?s 04 semanas in vivo. O estudo compreendeu a coloca??o de 50 implantes de tit?nio cp. no ter?o m?dio da t?bia de 10 coelhos, sendo a t?bia direita usada como controle e a esquerda como teste. No grupo teste procedeu-se a administra??o local de gel de alendronato de s?dio e no grupo controle foi utilizada solu??o salina est?ril. Ap?s a eutan?sia, 10 implantes de cada grupo foram destinados ? an?lise de torque m?ximo de remo??o. O restante da amostra foi processada para obten??o de l?minas n?o descalcificadas de aproximadamente 30μm de espessura, onde foram realizadas an?lises histomorfol?gica e histomorfom?trica de contato ossoimplante (%BIC). Os dados foram analisados com n?vel de signific?ncia de 5%. Os valores de torque m?ximo de remo??o do grupo teste foram, em m?dia, metade dos valores do grupo controle. O grupo teste demonstrou menor %BIC, bem como altera??es not?veis em qualidade ?ssea. Conclui-se que os eventos iniciais de osseointegra??o de implantes de tit?nio n?o s?o favorecidos pela aplica??o local de gel de alendronato de s?dio em coelhos.