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Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA SequencesWright, E.P., Day, H.A., Ibrahim, Ali I.M., Kumar, Jeethendra, Boswell, L.J.E., Huguin, C., Stevenson, C.E.M., Pors, Klaus 23 October 2016 (has links)
Yes / There are hundreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif. To appreciate an understanding between the dynamics between these structures and how they can be affected by intervention with small molecule ligands, more i-motif binding compounds are required. Herein we describe how the drug mitoxantrone can bind, induce folding of and stabilise i-motif forming DNA sequences, even at physiological pH. Additionally, mitoxantrone was found to bind i-motif forming sequences preferentially over double helical DNA. We also describe the stabilisation properties of analogues of mitoxantrone. This offers a new family of ligands with potential for use in experiments into the structure and function of i-motif forming DNA sequences.
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