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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
81

Repeated exposure to amphetamine promotes the self-administration of cocaine : sensitization and the contribution of brain dopamine-glutamate interactions /

Suto, Nobuyoshi. January 2002 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Psychology (Biopsychology), Dec. 2002. / Includes bibliographical references. Also available on the Internet.
82

Interaction of memantine with ethanol consumption and dopaminergic function in high ethanol preferring rats

Malpass, Gloria Elaine. McMillen, Brian. January 2009 (has links)
Thesis (Ph.D.)--East Carolina University, 2009. / Presented to the faculty of the Department of Pharmacology and Toxicology, the Brody School of Medicine at East Carolina University. Advisor: Brian McMillen. Title from PDF t.p. (viewed April 28, 2010). Includes bibliographical references.
83

Régulation et signalisation du récepteur dopaminergique D2 /

Maltais, Stéphane. January 2003 (has links)
Thèse (Ph. D.)--Université Laval, 2003. / Bibliogr.: f. 293-345. Publ. aussi en version électronique.
84

The effect of ethanol consumption on dopamine and ethanol concentrations in the nucleus accumbens during the development of reinforcement and the involvement of the k-Opioid receptor in the modulation of dopamine activity during ethanol self-administration

Doyon, William Maurice, January 1900 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2005. / Vita. Includes bibliographical references.
85

Prefrontal cortex D1 receptor regulation of mesolimbic dopamine and cocaine self-administration

Olsen, Christopher Mark, Duvauchelle, Christine L., January 2004 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2004. / Supervisor: Christine L. Duvauchelle. Vita. Includes bibliographical references.
86

Dopamine D1-like receptor-mediated regulation of NMDA receptor sensitivity to ethanol in the nucleus accumbens

Zhang, Tao, Morrisett, Richard A., January 2005 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2005. / Supervisor: Richard A. Morrisett. Vita. Includes bibliographical references.
87

Dopamine and the circulation in man

Kho, Tjioe Liang. January 1987 (has links)
Proefschrift Maastricht. / Met lit. opg. - Met samenvatting in het Nederlands.
88

Positron emission tomography of cerebral dopamine receptors synthesis and evaluation of agonists and drug response in schizophrenia /

Zijlstra, Sytse. January 1995 (has links)
Proefschrift Rijksuniversiteit Groningen. / Met lit.opg. - Met samenvatting in het Nederlands.
89

An investigation of the pharmacology and underlying mechanism of the responses to gamma-amino butyric acid and ethylenediamine of pyramidal neurones in the hippocampal slice preparation

Blaxter, Timothy John January 1984 (has links)
1. Hippocampal pyramidal neurones were successfully maintained in vitro in brain slices. 2. Stable intracellular recordings were made from pyramidal neurones in the CAl region of the pyramidal neurone layer. 3. The iontophoresis of acetylcholine, glutamate, GABA and ethylenediamine produced responses when applied to the dendrites and when applied to the cell body of pyramidal neurones. 4. Ethylenediamine may have acted indirectly on GABA receptors. 5. The depolarizing response of the pyramidal neurone dendrites to GABA was dependent on chloride ions and was also probably dependent on sodium ions. 6. The hyperpolarizing response of the pyramidal neurone dendrites to GABA and ethylenediamine was dependent on potassium ions. 7. The hyperpolarizing response of the pyramidal neurone cell body to GABA and ethylenediamine was dependent on potassium ions. 8. Bicuculline reduced the depolarizing response of the dendrites to GABA and ethylenediamine and reduced the hyperpolarizing response of the cell body to GABA. 9. Picrotoxin reduced the depolarizing response of the dendrites to GABA and ethylenediamine. 10. The hyperpolarizing response of the dendrites to GABA and ethylenediamine was not mediated by the usual bicuculllne-and picrotoxin-sensitive receptor. 11. Benzodiazepines had variable effects on the depolarizing response of the dendrites to GABA or ethylenedlamine and variable effects on the hyperpolarizing response of the cell body to GABA or ethylenediamine. Benzodiazepines had no effect on the hyperpolarizing response of the dendrites to EDA. 12. The hyperpolarizing response of the dendrites to GABA and ethylenediamine was distinct from the hyperpolarizing response of the cell body to GABA and ethylenediamine.
90

Electrospun fibre based colorimetric probes for biological molecules

Mudabuka, Boitumelo January 2014 (has links)
The thesis reports the use of electrospun nanofibres as a platform for the development of colorimetric probes. Three colorimetric probes in the form of electrospun nanofibre test strips were developed for the selective detection of ascorbic acid and dopamine because they are crucial biomolecules for physiological processes in human metabolism and usually coexist in biological samples. The simultaneous detection of the biomolecules is very important as their abnormal concentration levels would lead to diseases such as Parkinson's and schizophrenia. Different methods of incorporating detector agents into the nanofibre were exploited for the detection of the biomolecules. The methods included physical incorporation of nanoparticles, covalent bonding of ligand/dyes through surface modification of the fibres. The first colorimetric test strip for ascorbic acid was based on copper-gold alloy nanoparticles prepared in-situ and hosted in nylon6. The test strip showed selectivity in detecting ascorbic acid in the pH range 2 – 7. The suitability of fibres in hosting copper-gold alloy nanoparticles for the colorimetric detection of ascorbic acid was investigated using nylon6, poly(vinyl benzyl chloride)-styrene and cellulose acetate based test strips. All the test strips exhibited leaching and the nylon6 based test strip was found to be thermally stable up to 60 ˚C. The colorimetric performance of the test strips was maintained and neither was colour decay exhibited after 10 months of storage in a shelf. The test strip achieved an eye-ball limit of detection of 1.76 x10-2 mg L-1 and its suitability was demonstrated by the determination of ascorbic acid in fruit juices, urine, serum, and vitamin C tablets. The second colorimetric test strip for ascorbic acid and dopamine employed prussian blue synthesised in-situ in nylon6. Ascorbic acid turned the deep blue test strip to light blue at pH 3, and a faded navy blue colour at a pH range of 6 - 7 while dopamine changed the strip to purple at the same pH range. The versatility of the test strip was demonstrated by detecting ascorbic acid in commercial fruit juices as well as by detecting ascorbic acid as well as dopamine in fortified urine. The eye-ball detection limit of the Prussian blue test strip for ascorbic acid and dopamine was 17.6 mg L-1 and 18.9 mg L-1, respectively. The third method involved a covalent approach, where poly(vinylbenzyl chloride) nanofibers were post functionalised with 2-(2′-pyridyl)-imidazole and iron(III) for the selective detection of ascorbic acid and dopamine. The eye-ball detection limit for ascorbic acid and dopamine was 17.6 mg L-1 and 18.9 mg L-1, respectively. The test strip was selective for dopamine, but the detection of ascorbic acid suffered from interference by glutathione. The application of the test strips was nevertheless demonstrated by the detection of ascorbic acid in fruit juices and dopamine in fortified urine. The developed test strips employing the three approaches were applied without sample pre-treatment and use of supporting equipment.

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