Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-04-18T13:22:25Z No. of bitstreams: 1 EvelynHeinzenDissertacao2015.pdf: 2202789 bytes, checksum: 755c96a470572d0a8f58a0822ba09c8d (MD5) / Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-04-18T13:23:09Z (GMT) No. of bitstreams: 1 EvelynHeinzenDissertacao2015.pdf: 2202789 bytes, checksum: 755c96a470572d0a8f58a0822ba09c8d (MD5) / Made available in DSpace on 2017-04-18T13:23:09Z (GMT). No. of bitstreams: 1 EvelynHeinzenDissertacao2015.pdf: 2202789 bytes, checksum: 755c96a470572d0a8f58a0822ba09c8d (MD5) Previous issue date: 2015-09-22 / Organ transplantation is one of the greatest twentieth century advances in medicine, with success rates above 80%. Recent changes on donors profile, due to worldwide population aging, has led to modified organs acceptance criteria by the transplantation centers. This study aimed to describe the epidemiological, serological and clinical data of elderly organ donors, aged 60 years old or above, distributed by the National Transplant Center - NTC, Brazil, from 2011 to 2014, with special regard to organ donations progression and donation processes outcome related to the elderly organs donors. A descriptive, exploratory, retrospective, temporal and documentary series study was conducted with secondary data concerning Brazilian Federal Unit origin (UF), donation processes data and solid organs (heart, lung, liver and kidney) distribution, conducted by NTC, from 2011 to 2014, of older donors with 60 years or above. A total of 1,173 donation processes were analyzed, 38.6% of elderly donors were 60-64 years range and 31.5% were 65-69 years range. 57.9% were men and stroke (haemorrhagic) was the leading cause of death. Santa Catarina (20.2%), Cear?? (13%) and Rio de Janeiro (11.3%) were the most tendered states for national elderly organs distribution. Kidney was the most offered organ, followed by liver, heart and lung, in that order. Potential donor hospital stay was identified as an average of 5 - 6 days. Considering the use of vasoactive drugs and antibiotics, there was not a significant difference between donors with transplanted organs and donors with discarded organs. As for serologic tests, the presence or absence of a positive serologic test did not influence the acceptance of organs; however creatinine, urea and total bilirubin levels influenced this acceptance. Our results suggests that further researches are needed to better understand the old organ donor profile, consequently stimulating the use of organs from these donors by the transplantation centers and state transplant centers. / O transplante de ??rg??os foi um dos maiores avan??os obtidos pela medicina no s??culo XX, com ??ndice de sucesso acima de 80%. A mudan??a no perfil do doador, devido ao envelhecimento populacional em todo o mundo, tem ocasionado modifica????es nos crit??rios de aceita????o dos ??rg??os pelas equipes transplantadoras. O presente trabalho buscou descrever o perfil epidemiol??gico, cl??nico e sorol??gico dos doadores de ??rg??os idosos com 60 anos ou mais, provenientes da Central Nacional de Transplante ??? CNT, Brasil: 2011 a 2014, a evolu????o do n??mero de doa????es de ??rg??os e o desfecho do processo de doa????o quanto ao aproveitamento dos ??rg??os de doadores idosos. Para tal, foi realizado um estudo descritivo, explorat??rio, retrospectivo, de s??rie temporal e documental, com dados secund??rios, abrangendo as Unidades da Federa????o (UF) do Brasil, para os anos de 2011 a 2014, provenientes dos processos de doa????o / distribui????o de ??rg??os s??lidos (cora????o, pulm??o, f??gado, rim e p??ncreas), realizados pelo CNT por doadores com 60 anos ou mais. Foram analisados 1.173 processos de doa????o nos quais, 38,6% dos doadores tinham entre 60 e 64 anos, e 31,5%, entre 65 e 69 anos. Quanto ao sexo, 57,9% dos doadores eram homens e o AVC ??? H foi a principal causa de morte. Em rela????o ??s disponibiliza????es de ??rg??os pelas Unidades Federativas para distribui????o nacional, Santa Catarina (20,2%), Cear?? (13%) e Rio de Janeiro (11,3%) foram as que mais ofertaram. Os principais ??rg??os ofertados foram: rim, f??gado, cora????o e pulm??o, nesta ordem. Quanto ao tempo de interna????o do potencial doador, a m??dia de interna????o foi de 5 a 6 dias. E quanto ao uso de droga vasoativa e antibi??tico n??o foi significativa a diferen??a entre doadores com ??rg??os transplantados e doadores com ??rg??os descartados. No que tange ?? sorologia, a presen??a ou n??o das sorologias estudadas positivas n??o influenciou na aceita????o do ??rg??o, no entanto, as vari??veis creatinina, ureia e bilirrubina quando alteradas, representaram maior possibilidade de descarte desses ??rg??os. A partir desses resultados, sugere-se a realiza????o de mais pesquisas com o objetivo de conhecer o perfil do doador idoso de ??rg??os e, mediante isso, estimular o aproveitamento dos ??rg??os provenientes desses doadores pelas equipes transplantadoras e Centrais Estaduais de Transplantes.