Graduation date: 1991

Innovation is the fundamental driver for the advancement of societies. The advent of the Industrial Revolution in the 17th century precipitated a dramatic increase in the rate of innovation. Societies of the time struggled in how to deal with the rapid changes that resulted from these innovations and their application. Present day society is no different. Innovations in todays society have the ability to be widely adopted and the potential to affect far larger segments of the population that previous innovations. The rapid rise of genetic modification is one such innovation. This innovative technology has been widely adopted by the drug and agriculture industries and as a result, it has impacted all segments of Canadian society. This thesis examines how Canadian society has dealt with the specific innovation of agricultural biotechnology, or the genetic modification of plants. The commercialization of genetically modified plants has resulted in regulatory challenges for the government, intellectual property and liability concerns for industry and consumer acceptance issues within the general public. By researching the interaction and relationships between government regulators, private firms and consumer organizations, it is possible to identify how Canada has reacted to the challenge of regulating agricultural biotechnology. The interdisciplinary framework necessary to accomplish this requires conceptual contributions from economics, political science and sociology. In the development of the innovation, or innovative product, the regulatory approval process requires a risk analysis for all new plant varieties. This risk analysis process is comprised of risk assessment, risk management and risk communication. This thesis argues that risk and the application of risk analysis is appropriate for pre-commercialization, but once the innovative product is in the marketplace, any failure regarding this product can be viewed as a potential liability. The management of and communication about liabilities differs from that of risk management and communication. The key theme of this research is to examine how regulators in Canada have attempted to regulate post-commercialization liabilities and to identify what governance structures or institutions are essential for the regulation of post-commercialization liabilities.

The contemporary emergence of payday lending as a major source of high-cost short-term credit for credit-constrained populations has prompted debates among government officials, business representatives, advocacy groups and academics over how best to regulate the industry. Such debates typically focus on the prevailing lending practices and interest charges in the industry. While critics associate these with usury, supporters of payday lenders defend them as appropriately priced responses to market demand. This dissertation seeks to contextualize, and contribute to a deeper understanding of, the terms of these debates through an exploration of the recently concluded political exercise in Canada where responsibility for the governance of payday lending has been shifted from the federal government, with its criminal law power over usury, to provincial governments with their various regulatory powers over licensing and consumer protection. The dissertation begins with the observation that there are competing moral discourses about money and interest simultaneously embedded in the financial policy-making process in Canada, a fact that has complicated regulatory efforts aimed at payday lending. While these efforts have largely been informed by varying assessments of the transparency and competiveness of the payday lending market, this dissertation contends that a conceptually more useful way of understanding this market is to study the organizational and marketing strategies employed by payday lenders to indentify and retain a stable customer base, and the reciprocal moves on the part of customers to improve upon their terms of trade. In detailing the political process which culminated in a new regulatory regime for payday lending, this dissertation draws on the “regulation through networks” literature to help explain its progress. A major contribution this dissertation makes to this explanatory approach is in its emphasis on the dual legitimation imperatives with which the network actors had to contend as they negotiated their way to a consensus on a politically acceptable regulatory structure for payday lending. This consensus has proved to be politically vulnerable because of the continuing normative conflicts embedded in official financial policy discourse, and inter alia, in the legitimation imperatives which have permeated the policy-making process.

Psychologists have long been directing their energy to the domain of moral judgment or moral prediction, assuming that when extended to moral behaviour, results will prove consistent. The aim of this research was to explore the dissociation between moral prediction and moral behaviour. Pilot research suggests that people expect others to act less morally than they say they would. The results of two experiments, however, suggest the opposite. In both studies, participants were assigned to either a moral action condition, where they were placed in a moral dilemma, or a moral prediction condition, in which they had to predict their behavior in that dilemma. In Study 1, the Dictator Game was used to measure morality, whereas in Study 2, cheating behaviour was measured. In both experiments, participants acted more morally than they predicted they would. This research has implications for scrutinizing the applicability of previous work on moral self-prediction.

The 80 S cytoplasmic ribosome is the largest of three populations of ribosomes responsible for protein synthesis in plants. It is comprised of two RNA/protein subunits of unequal size: the small (40 S) subunit selects messages to be translated and performs proofreading, while the large (60 S) subunit has peptidyl transferase acitivity, adding new amino acids to the growing polypeptide. In the model flowering plant <i>Arabidopsis thaliana</i> (hereafter <i>Arabidopsis</i>), four ribosomal RNAs and 81 ribosomal proteins (r-proteins) assemble to form the 80S ribosome. Although the <i>Arabidopsis</i> ribosome contains only a single copy of each of the 81 r-proteins (with the exception of small number of acidic phophoproteins), all r-proteins are encoded from multi-gene families containing two or more expressed members. Herein, I investigated r-protein paralogy in Arabidopsis via specific examination of a two member gene family, RPL23a. By analyzing patterns of reporter gene expression driven by full-length and truncated regulatory regions, I was able to identify a core promoter that is largely conserved between paralogs. Regulation was found to be complex, involving transcriptional, post-transcriptional and translational components. The effects of knocking-out a single RPL23a paralog (RPL23aB) were determined. Results indicated that this paralog is broadly dispensable, and Arabidopsis does not compensate for its loss at the transcriptional level. Subcellular localization was investigated by tagging RPL23aA/B with fluorescent proteins, demonstrating that RPL23aA is targeted to nucleolus more efficiently than RPL23aB, possibly due to a stronger nucleolar localization signal. RNA-interference was used to individually silence RPL23a paralogs to characterize functional overlap. Results showed that RPL23aA, and not RPL23aB, is required for normal development. Mutants with reduced levels of RPL23aA develop a pointed first leaf phenotype that I postulate may be due to disruption of miRNA-mediated degradation of specific auxin response genes. Lastly, the 26 S proteasome was inhibited to determine the importance of protein turnover in regulating RPL23a levels. Findings suggest that proteasome-mediated degradation of RPL23a is essential for preventing accumulation of unincorporated r-proteins. Overall, results indicate that the Arabidopsis RPL23a paralogs have diverged from each other: RPL23aA has become the predominant paralog, while RPL23aB functions in an anciliary capacity and/or is undergoing neofunctionalization.

Psychologists have long been directing their energy to the domain of moral judgment or moral prediction, assuming that when extended to moral behaviour, results will prove consistent. The aim of this research was to explore the dissociation between moral prediction and moral behaviour. Pilot research suggests that people expect others to act less morally than they say they would. The results of two experiments, however, suggest the opposite. In both studies, participants were assigned to either a moral action condition, where they were placed in a moral dilemma, or a moral prediction condition, in which they had to predict their behavior in that dilemma. In Study 1, the Dictator Game was used to measure morality, whereas in Study 2, cheating behaviour was measured. In both experiments, participants acted more morally than they predicted they would. This research has implications for scrutinizing the applicability of previous work on moral self-prediction.

Personlighetsdragen openness och extraversion respektive situationsfaktorerna variation, intensitet, samt frekvens och deras påverkan på emotionsregleringsstrategierna reappraisal samt suppression skiljer sig inom yrkesgrupperna vård respektive handel. Åtta regressions-analyser med data från sammanlagt 178 anställda visade att (1) inom vården har extraversion, openness, samt frekvens betydelse för reappraisal, och intensiteten påverkar suppression, och (2) för handel visade sig openness och situationen som helhet ha betydelse för suppression, medan inga samband kunde påvisas för reappraisal. Skillnaderna tyder på att det finns ett behov av fortsatt forskning inom emotionsreglering, inriktad på skillnader mellan olika yrkesgrupper. / Personality traits openness and extraversion, and situational factors variation, intensity and frequency respectively influence emotion regulation techniques reappraisal and suppression differently within the professions of human service and service/sales. Eight regression analyses with data from a total of 178 employees showed that (1) within human service, extraversion, openness, and frequency are important to reappraisal whereas intensity plays a role for suppression. (2) Within service/sales none of the variables influenced reappraisal, and only openness and the situation “as a whole” played a role for suppression. The results indicate a need for more scientific research regarding differences in predictions of emotion regulation between occupations.

This thesis models rational criminals and regulators with flawed incentives. In it we develop a rational model of crime and regulation that we use to show the SEC's current incentive structure is ineffective at preventing fraud. Under our model, criminals balance the monetary rewards of larger frauds against an increased chance of being apprehended; and regulators design regulations to minimize either the damage caused by fraud or some other metric. We show that under this model, the SEC's focus on 'stats' and 'quick hits' leads to large frauds and a large social loss. We argue that regulators need to focus not just on successful prosecutions, but also on harm reduction and deterrence.

Innovation is the fundamental driver for the advancement of societies. The advent of the Industrial Revolution in the 17th century precipitated a dramatic increase in the rate of innovation. Societies of the time struggled in how to deal with the rapid changes that resulted from these innovations and their application. Present day society is no different. Innovations in todays society have the ability to be widely adopted and the potential to affect far larger segments of the population that previous innovations. The rapid rise of genetic modification is one such innovation. This innovative technology has been widely adopted by the drug and agriculture industries and as a result, it has impacted all segments of Canadian society. This thesis examines how Canadian society has dealt with the specific innovation of agricultural biotechnology, or the genetic modification of plants. The commercialization of genetically modified plants has resulted in regulatory challenges for the government, intellectual property and liability concerns for industry and consumer acceptance issues within the general public. By researching the interaction and relationships between government regulators, private firms and consumer organizations, it is possible to identify how Canada has reacted to the challenge of regulating agricultural biotechnology. The interdisciplinary framework necessary to accomplish this requires conceptual contributions from economics, political science and sociology. In the development of the innovation, or innovative product, the regulatory approval process requires a risk analysis for all new plant varieties. This risk analysis process is comprised of risk assessment, risk management and risk communication. This thesis argues that risk and the application of risk analysis is appropriate for pre-commercialization, but once the innovative product is in the marketplace, any failure regarding this product can be viewed as a potential liability. The management of and communication about liabilities differs from that of risk management and communication. The key theme of this research is to examine how regulators in Canada have attempted to regulate post-commercialization liabilities and to identify what governance structures or institutions are essential for the regulation of post-commercialization liabilities.

The 80 S cytoplasmic ribosome is the largest of three populations of ribosomes responsible for protein synthesis in plants. It is comprised of two RNA/protein subunits of unequal size: the small (40 S) subunit selects messages to be translated and performs proofreading, while the large (60 S) subunit has peptidyl transferase acitivity, adding new amino acids to the growing polypeptide. In the model flowering plant <i>Arabidopsis thaliana</i> (hereafter <i>Arabidopsis</i>), four ribosomal RNAs and 81 ribosomal proteins (r-proteins) assemble to form the 80S ribosome. Although the <i>Arabidopsis</i> ribosome contains only a single copy of each of the 81 r-proteins (with the exception of small number of acidic phophoproteins), all r-proteins are encoded from multi-gene families containing two or more expressed members. Herein, I investigated r-protein paralogy in Arabidopsis via specific examination of a two member gene family, RPL23a. By analyzing patterns of reporter gene expression driven by full-length and truncated regulatory regions, I was able to identify a core promoter that is largely conserved between paralogs. Regulation was found to be complex, involving transcriptional, post-transcriptional and translational components. The effects of knocking-out a single RPL23a paralog (RPL23aB) were determined. Results indicated that this paralog is broadly dispensable, and Arabidopsis does not compensate for its loss at the transcriptional level. Subcellular localization was investigated by tagging RPL23aA/B with fluorescent proteins, demonstrating that RPL23aA is targeted to nucleolus more efficiently than RPL23aB, possibly due to a stronger nucleolar localization signal. RNA-interference was used to individually silence RPL23a paralogs to characterize functional overlap. Results showed that RPL23aA, and not RPL23aB, is required for normal development. Mutants with reduced levels of RPL23aA develop a pointed first leaf phenotype that I postulate may be due to disruption of miRNA-mediated degradation of specific auxin response genes. Lastly, the 26 S proteasome was inhibited to determine the importance of protein turnover in regulating RPL23a levels. Findings suggest that proteasome-mediated degradation of RPL23a is essential for preventing accumulation of unincorporated r-proteins. Overall, results indicate that the Arabidopsis RPL23a paralogs have diverged from each other: RPL23aA has become the predominant paralog, while RPL23aB functions in an anciliary capacity and/or is undergoing neofunctionalization.