Global ETD Search

641	Structural specificity of organic cation transport in rabbit renal brush border membrane vesicles Ayer, Katherine Dorothy January 1988 (has links) Organic cations (OC's) are actively secreted by the renal proximal tubules in a number of species. The transepithelial transport of OC's involves a secondary active OC/H+ exchange process at the brush border (luminal) membrane. This study employed rabbit renal brush border membrane vesicles (BBMV) to investigate the structural requirements associated with substrate recognition at the OC transporter. A number of compounds (an N-alkylammonium series, an N1-alkylpyridinium series and some clinically important organic bases) were tested for their ability to competitively block the uptake of radioactively labelled tetraethylammonium (TEA) into BBMV. The inhibitory effectiveness of these compounds was correlated to the degree of hydrophobicity surrounding the positively-charged nitrogenous nucleus common to all the inhibitors. Preloading BBMV with N1-substituted pyridines trans-stimulated the uptake of TEA, suggesting that these compounds are translocated substrates for the OC transporter. The activity of the OC transport inhibitor and neurotoxin 1-methyl-4-phenylpyridinium was of special interest, and thus its transport characteristics were fully evaluated. Renal tubular transport. Cations -- Secretion -- Regulation.
642	Effects of diet on amylase content and synthesis in cultured rat acinar cells Justice, Jill Diane, 1963- January 1989 (has links) To study adaptation of pancreatic amylase to diet, an affinity adsorbent, alpha-GHI-AH-Sepharose 4B, was used to determine amylase synthesis in cultured pancreatic acinar cells. This adsorbent exhibited a consistent binding capacity and was specific for amylase. Acinar cells from rats fed high fat (HF) or carbohydrate (HC) diets for 7 d were cultured 1-48 h in serum-free medium. Amylase activity remained significantly higher in HC cells than in HF cells through 24 h in culture, despite its decrease with time in culture. The relative synthesis of amylase (3H-phe amylase/3H-phe total protein x 100) was significantly higher in HC than in HF cells at isolation and remained higher during culture. These results demonstrate that this affinity adsorbent can be used to determine amylase synthesis and suggest that the effect of diet on amylase activity and relative synthesis persists in cultured pancreatic acinar cells. Amylases -- Secretion -- Regulation. Pancreatic acinar cells.
643	The expression and function of B-myb in the cell cycle Robinson, Cleo January 1995 (has links) No description available. 572.8
644	Electrode measurement on the net charge on muscle proteins Bryson, Elzbieta Anna January 1997 (has links) No description available. 571.4
645	Molecular analysis of the human CD2 Locus Control Region in transgenic mice Festenstein, Richard January 1996 (has links) No description available. 572.8
646	Studies on the control of nitrate reductase in Sinapsis alba Rollinson, Sara Jayne January 1995 (has links) No description available. 580
647	Intracellular cytokines and their therapeutic modulation in immunological disorders Sewell, William Arthur Carrock January 2000 (has links) No description available. 572.8
648	Structure and function of the platelet and T-cell activation antigen-1 (PTA1) Adamson, Janet January 2000 (has links) No description available. 572.8
649	The decline of the roe deer (Capreolus capreolus L.) in the New Forest, Hampshire Sharma, Surender K. January 1994 (has links) No description available. 577
650	Interactions between auxin efflux carriers and NPA receptors in higher plant cells Wilkinson, Sally January 1993 (has links) No description available. 580

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