Software maintenance accounts for the most part of the software development cost and efforts, with its major activities focused on the detection, location, analysis and removal of defects present in the software. Although software defects can be originated, and be present, at any phase of the software development life-cycle, implementation (i.e., source code) contains more than three-fourths of the total defects. Due to the diverse nature of the defects, their detection and analysis activities have to be carried out by equally diverse tools, often necessitating the application of multiple tools for reasonable defect coverage that directly increases maintenance overhead. Unified detection tools are known to combine different specialized techniques into a single and massive core, resulting in operational difficulty and maintenance cost increment. The objective of this research was to search for a technique that can detect dissimilar defects using a simplified model and a single methodology, both of which should contribute in creating an easy-to-acquire solution. Following this goal, a ‘Supervised Automation Framework’ named FlexTax was developed for semi-automatic defect mapping and taxonomy generation, which was then applied on a large-scale real-world defect dataset to generate a comprehensive Defect Taxonomy that was verified using machine learning classifiers and manual verification. This Taxonomy, along with an extensive literature survey, was used for comprehension of the properties of different classes of defects, and for developing Defect Similarity Metrics. The Taxonomy, and the Similarity Metrics were then used to develop a defect detection model and associated techniques, collectively named Symbolic Range Tuple Analysis, or SRTA. SRTA relies on Symbolic Analysis, Path Summarization and Range Propagation to detect dissimilar classes of defects using a simplified set of operations. To verify the effectiveness of the technique, SRTA was evaluated by processing multiple real-world open-source systems, by direct comparison with three state-of-the-art tools, by a controlled experiment, by using an established Benchmark, by comparison with other tools through secondary data, and by a large-scale fault-injection experiment conducted using a Mutation-Injection Framework, which relied on the taxonomy developed earlier for the definition of mutation rules. Experimental results confirmed SRTA’s practicality, generality, scalability and accuracy, and proved SRTA’s applicability as a new Defect Detection Technique.