Global ETD Search

181	Vascular-related cell responses to dietary zinc deficiency Ou, Ou January 2013 (has links) Zinc (Zn) is an essential trace element and its deficiency is known to compromise a wide range of functions, including vascular function and immune function. The hypothesis of the thesis was that suboptimal Zn status would induce changes in the vascular system, thus raising the potential risk of developing atherosclerosis. After 2 wk, aorta was taken from male adult rats fed by either acute Zn deficient (AZD, <1mg Zn/kg), Zn adequate Pair fed of AZD (PF, 35mg Zn/kg), or Zn adequate control (ZA, 35mg Zn/kg, fed ad libitum) diet. It was found most genes which were significantly regulated between AZD and PF aorta belong to cytoskeleton remodelling. Plasma from the same rats was used to incubate primary VSMC in vitro. Dramatic changes of gene expression in pathways associated with immune function. While AZD plasma induced marked changes in VSMC gene expression in vitro, no significant change was found by depleting Zn from PF plasma. Therefore it is possible that a Zn deficiency induced humoral factor was responsible for influencing VSMC gene expression. By semi-purifying plasma using gel filtration and molecular filtration, it was confirmed that the humoral factor has a molecular weight of around 2kDa and is thought to be a peptide hormone, which could serve as a potential biomarker of Zn status. Splenocytes and whole blood were taken from rats and used to measure cytokine secretion before and after either LPS or ConA treatment. Different concentrations of several cytokines, such as IL2, IL6, TNFα and IFNγ were found from different Zn status. Overall the thesis emphasises the participation of Zn in several aspects of the vascular system, such as regulating cytokine production and maintaining vascular structure. It provides important evidence of the role that Zn plays in the development of atherosclerosis. 613.2
182	Molecular studies of a glucose-6-phosphate dehydrogenase variant 陳嘉儀, Chen, Kar-yee, Agnes. January 1996 (has links) published_or_final_version / Biochemistry / Master / Master of Philosophy
183	A comparative study of two recombinant human glucose-6-phosphate dehydrogenase (G6PD) deficient variants with the normal enzyme Wang, Xiaotao, 王曉濤 January 2000 (has links) published_or_final_version / Biochemistry / Master / Master of Philosophy Enzymes.
184	Total protein concentrations as a predictor variable in decubitus ulcer formation in the geriatric population Gardner, Arlene Patricia Howsley January 1979 (has links) No description available. Bedsores. Older people -- Wounds and injuries. Protein deficiency.
185	Human induced pluripotent stem cells for in vitro modeling and cell based therapy of α-1 antitrypsin deficiency Rashid, Sheikh Tamir January 2012 (has links) No description available. 617
186	Identification of bioactive molecules for the treatment of alpha₁-antitrypsin deficiency Ekeowa, Ugochukwu Ifedi January 2012 (has links) No description available. 610
187	Hemolytic complement activity in the thiamine deficient guinea pig Crisman, Jon Eliot, 1939- January 1967 (has links) No description available. Vitamin B1 deficiency. Complement (Immunology) Blood proteins.
188	Response of parents to the problem of anemia McNally, Marian Agnes, 1925- January 1970 (has links) No description available. Iron deficiency anemia. Children -- Nutrition. Parent and child.
189	The effects of folic acid deficiency on phagocytosis and susceptibility to infection Pathak, Hemantkumar Yeshwantrai, 1929- January 1960 (has links) No description available. Folic acid deficiency. Disease susceptibility. Phagocytosis.
190	The effects of niacin deficiency on phagocytosis and susceptibility to infection Siebeling, Ronald Jon, 1937- January 1962 (has links) No description available. Disease susceptibility. Niacin. Deficiency diseases. Phagocytosis.

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