Thesis (Ph. D.)--University of Washington, 1994. / Vita. Includes bibliographical references (leaves [66]-81).

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2010.

Attention Deficit Hyperactivity Disorder (ADHD) is a relatively common psychiatric disorder affecting 5-10% of child and 4% of the adult population. The disorder involves both behavioural problems and cognitive deficits, which are believed to be associated with neurological differences seen in this population. There has been increasing interest in understanding the cognitive deficits and neurological basis associated with ADHD. Neuropsychological examinations are an affordable tool, which can be used to improve our understanding of the cognitive deficits associated with the disorder and aid in clinical care. Currently, there is no standardized neuropsychological assessment that can be used in this population. In order to assist in developing a sound, predominately computerized test battery, which would assess deficits commonly seen in adults with ADHD, a neuropsychological project was piloted to examine recruitment and test utility. The majority of the tests were computerized and had population norms. The test battery was piloted on 8 patients on and off medication, and 4 patients completed the test battery twice off medication to examine potential practice effects. A discussion of feasibility and utility of the neuropsychological test battery for adults with ADHD ensues.

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2007. / Härtill 4 uppsatser.

Thesis (Ph. D.)--Virginia Commonwealth University, 2007. / Prepared for: School of Allied Health Professions . Bibliography: leaves 96 - 114. Also available online via the Internet.

Dissertation (Ph.D) -- University of Texas Southwestern Medical Center at Dallas, 2006. / Vita. Bibliography: pp. 192-222.

No description available.

No description available.

The catechol-O-methyltransferase (COMT) gene is the predominant means of dopamine deactivation within the prefrontal cortex (PFC), a brain locus implicated in Attention deficit/hyperactivity disorder (ADHD). Dopamine dysregulation is a significant contributor to the pathophysiology of ADHD and Methylphenidate (MPH), an effective treatment for ADHD, and acts at least in part, through modulation of dopamine levels in the PFC. Thus, we tested the hypothesis that the Catechol-O-Methyltransferase (COMT) Val108/158 Met polymorphism modulates behavioral dimensions relevant for ADHD and/or response of these behavioral dimensions to MPH and/or neuropsychological functions considered relevant for ADHD. No genotype or genotype by treatment interaction effects were observed for behavioral response to MPH. No genotype effects were observed using the family-based approach. Marginal genotype effects were observed between the Met/Met genotype and some but not all aspects of executive functioning. Overall, these results do not support the implication of the COMT Val108/158 Met polymorphism in ADHD, ADHD relevant behaviours or response to methylphenidate, but weakly implicate COMT gene in some aspects of executive functions in children with ADHD. Given that gene effects on behaviours are likely to be very small, a much large sample would be needed in order to establish these results, both negative and positive, with better confidence.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 5 uppsatser.