This causal-comparative and correlational study examined cross-cultural adaptability of randomly selected licensed dental hygienists, 1995-2005 graduates, practicing in the state of Texas and first and second-year dental hygiene students attending 5 randomly selected accredited 2 and 4-year dental hygiene schools in the state of Texas. A sample of 289 individuals: 194 enrolled students and 95 licensed dental hygienists, alumni of the 5 schools, completed the 50-item Cross-Cultural Adaptability Inventory (CCAI ®) and a brief demographic survey. The purpose of this study was to determine if statistically significant differences existed among and between licensed dental hygienists and first and second-year dental hygiene students in the state of Texas on a cross-cultural adaptability measure. The study also examined relationships among and between cross-cultural adaptability scores, as measured by the CCAI, and several independent variables. The data were analyzed by using the Statistical Package of Social Sciences (SPSS 12). Eight hypotheses related to group differences and relationships among and between groups and variables were tested. The groups were compared on total CCAI scores using a t-test, and on subscale CCAI scores simultaneously using a descriptive discriminant analysis (DDA). A 3X2 MANOVA was used to compare all groups simultaneously on subscale CCAI scores. The sample was also analyzed for statistically significant differences among 3 levels of ethnicity and total CCAI scores using a one-way analysis of variance (ANOVA). Lastly, various Pearson correlation analyses were conducted to determine relationships among and between the 3 independent variables mentioned above and total and subscale CCAI scores. The results revealed no statistically significant differences among the various groups and CCAI scores. A statistically significant relationship (r = .148) was found between age and 1 of the 4 CCAI subscale scores, flexibility/openness. No other statistically significant relationships were found. The study concluded that number of years for degree, level of practice, ethnicity, and years employed may not play a significant role in enhancing cross-cultural adaptability. Further research needs to be conducted to determine differences and relationships between and among various dental hygiene groups and their cross-cultural adaptability performance.