Five chemicals indigenous to the dental office environment that may cause toxic effects are formaldehyde, phenol, acrylic, mercury, and nitrous oxide. These chemicals create abnormal stress on physiological and psychological systems of the body resulting in symptomatology and pathology when the body defenses can no longer maintain homeostasis by adaptation. This study demonstrated serious behavioral consequences of chemical and heavy metal exposure. This study provided evidence that a significant percentage of dental office personnel who are exposed to the dental office chemicals show psycho neurological dysfunction. It was concluded that these individuals suffer adverse reactions to the chemicals in their work environment. The problem areas included perceptual motor difficulty in cognitive functioning, concern with bodily functions, despondency, and interpersonal problems.