Magister Educationis - MEd / Role-play is a teaching strategy which is very useful in enhancing the acquisition of knowledge and conceptualisation of some topics in Life Science. According to the theory of constructivism, learning science is a process in which learners construct understanding of the materials. Role-play and constructivism are intertwined, yet role-play as a teaching strategy lacks classroom application in the teaching of Life Sciences. Role-play is not often used in the teaching of Life Sciences, and to be specific, in the teaching of the circulatory system. The study is motivated by learners’ misconceptions of the circulatory system. The study is undertaken to determine the effect of role play on the learners’ conception about the human circulatory system. Random sampling resulted in the selection of one out of 6 grade 10 classes with 49 learners in each from one school in the Metro East District in Cape Town.