This work presents an effective methodology for measuring the depth-resolved 3D full-field deformation of semitransparent, light scattering soft tissues such as vertebrate eye cornea. This was obtained by performing digital volume correlation on optical coherence tomography volume reconstructions of silicone rubber phantoms and porcine cornea samples. Both the strip tensile tests and the posterior inflation tests have been studied. Prior to these tests, noise effect and strain induced speckle decorrelation were first studied using experimental and simulation methods. The interpolation bias in the strain results has also been analyzed. Two effective approaches have been introduced to reduce the interpolation bias. To extract material constitutive parameters from the 3D full-field deformation measurements, the virtual fields method has been extended into 3D. Both manually defined virtual fields and the optimized piecewise virtual fields have been developed and compared with each other. Efforts have also been made in developing a method to correct the refraction induced distortions in the optical coherence tomography reconstructions. Tilt tests of different silicone rubber phantoms have been implemented to evaluate the performance of the refraction correction method in correcting the distorted reconstructions.

Ce travail présente une méthodologie efficace pour mesurer le champ de déformation total en 3-D des tissus mous semi-transparents et diffusant la lumière, tels que la cornée de l'œil vertébré. Cela a été obtenu en utilisant la tomographie par cohérence optique couplée avec la corrélation volumique numérique sur des fantômes en caoutchouc de silicone et de la cornée porcine. Des tests de traction et des tests d'inflation postérieure ont été étudiés. Avant ces tests, l'effet du bruit et la décorrélation des speckles due à la déformation sont d'abord étudiés en utilisant des méthodes expérimentales et numériques. Le biais d'interpolation dans les résultats de déformation a été analysé. Deux approches efficaces ont été prises pour réduire le biais d'interpolation. Pour extraire les paramètres constitutifs des mesures de déformation 3-D, la méthode des champs virtuels a été étendue en 3-D. Les champs virtuels définis manuellement et les champs virtuels optimisés par morceaux ont été développés et comparés entre eux. Des efforts ont également été déployés pour corriger les distorsions induites par réfraction dans les reconstructions de la tomographie par cohérence optique. Des tests d'inclinaison des différents fantômes de silicone ont été introduits afin d’évaluer la performance de la méthode pour corriger les reconstructions distordues / This work presents an effective methodology for measuring the depth-resolved 3-D full-field deformation of semitransparent, light scattering soft tissues such as vertebrate eye cornea. This was obtained by performing digital volume correlation on optical coherence tomography volume reconstructions of silicone rubber phantoms and porcine cornea samples. Both the strip tensile tests and the posterior inflation tests have been studied. Prior to these tests, noise effect and strain induced speckle decorrelation were first studied using experimental and simulation methods. The interpolation bias in the strain results has also been analyzed. Two effective approaches have been introduced to reduce the interpolation bias. To extract material constitutive parameters from the 3-D full-field deformation measurements, the virtual fields method has been extended into 3-D. Both manually defined virtual fields and the optimized piecewise virtual fields have been developed and compared with each other. Efforts have also been made in developing a method to correct the refraction induced distortions in the optical coherence tomography reconstructions. Tilt tests of different silicone rubber phantoms have been implemented to evaluate the performance of the refraction correction method in correcting the distorted reconstructions