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The Effects of Epidural Deracoxib on the Ground Reaction Forces in an Acute Stifle Synovitis ModelKarnik, Priti S. 13 June 2005 (has links)
Objective: To evaluate epidurally administered deracoxib and its ability to mediate clinical signs and effects of a sodium urate crystal-induced stifle synovitis in dogs, and to compare the effects of epidural versus subcutaneously injected deracoxib.
Study Design: Experimental, randomized, double-blinded, placebo controlled modified cross over design.
Animals or Study Population: 24 random source adult mixed breed dogs, 14 males and 10 females.
Methods: Sodium urate crystals were used to create a stifle synovitis model to evaluate the effectiveness of administered deracoxib. Dogs were divided into four treatment groups; 3 mg/kg epidural deracoxib, 1.5 mg/kg epidural deracoxib, 3 mg/kg subcutaneous deracoxib and a placebo group (the vehicle for deracoxib was used). Force plate and subjective evaluations were performed at Time 0, 2, 4, 8, 12, and 24 hours post treatment. A repeated measures ANOVA with Bonferroni-corrected post-hoc comparisons was used to determine treatment effects.
Results: Overall, peak vertical force (PVF) and vertical impulse (VI) were both significantly higher in all deracoxib treated dogs compared to placebo. Both 3 mg/kg epidural and subcutaneous deracoxib had significantly higher PVF and VI than 1.5 mg/kg epidural deracoxib. The overall pain score for all deracoxib treated dogs was significantly lower than the placebo treated dogs.
Conclusions: Epidural deracoxib is effective at providing analgesia in an acute pain model, but it does not appear to be more effective than systemic administration.
Clinical Relevance: The use of injectable deracoxib is effective in providing analgesia in acute inflammatory conditions of the stifle joint in dogs. / Master of Science
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Évaluation de l'efficacité d'inhibiteurs de la cyclooxygénase dans le traitement de tumeurs mammaires canines in vivoSonzogni-Desautels, Karine January 2008 (has links)
Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.
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Évaluation de l'efficacité d'inhibiteurs de la cyclooxygénase dans le traitement de tumeurs mammaires canines in vivoSonzogni-Desautels, Karine January 2008 (has links)
Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal
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