Diabetes Care Program of Nova Scotia (DCPNS) Registry data were used to examine factors associated with survival for clinically confirmed diabetes mellitus (DM) cases. Type 1 (N=2,043) and type 2 (N=47,974) cases were followed from first Diabetes Centre visit until death/study end. Kaplan Meier curves and Cox proportional hazard models were used to explore differences in survival by sex, district health authority of care, and comorbidity status (hypertension and/or dyslipidemia). Median lifespan for type 1 cases was 12 years shorter than for type 2 cases. Hazard rate ratios for those with dyslipidemia, hypertension, or both compared to those with neither comorbidity were 1.63, 2.57, and 7.52 for type 1 cases and 0.95, 1.15, and 1.00 for type 2 cases. Disease progression and the relationship between comorbidity status and survival differed markedly for the type 1 and type 2 DM populations underscoring the need to examine these populations separately.