The validity of two measures of dietary diversity derived from a qualitative diversity questionnaire (reference periods of 1 or 7 days) by comparison with nutrient intake from three 24-hour recalls was investigated in 51 women (18--45 y) in a peri-urban community in Senegal, West Africa. Significant positive correlations (range: r = 0.30 to r = 0.64) were found between intakes of calcium, iron, zinc, vitamin A, vitamin C, thiamine, riboflavin and vitamin B6 and diversity score based on number of different individual foods derived from data obtained from the 7-day reference period. Data from the diversity score from the 1-day reference period was less well correlated with the 24-hr recalls. Our data suggest that a diversity measure based on foods derived from a diversity questionnaire would be useful in the monitoring of nutrient intake changes over time within populations.

Study Objective. To assess the dietary intakes of children with Attention Deficit Hyperactivity Disorder (ADHD); including macro- and micronutrient intake, the percentage of low nutrient density foods in the diet, as well as specific biochemical and anthropometric parameters. Design. Observational study. Setting. Provincial ADHD Program of BC, Children’s’ Hospital, Vancouver, BC. Sample. 44 children aged 6 - 12 years with ADHD, treatment-naïve or stable on medication for 6 months or longer. Main Results. ADHD Children were taller and heavier than population norms, and significantly taller than previously reported in ADHD. Of children aged 6-8 years, 28% were below the Estimate Average Requirement (EAR) for zinc and 61% of children aged 9-12 years were below the EAR for zinc. In addition, 28% of children aged 6-8 years and 39% of children aged 9-12 years were below the EAR for copper. Only 2% of children in the sample were below lab normal cutoffs for ferritin; however, 73% had serum zinc values below lab normal cut-offs and 23% had serum copper below lab normal cutoffs. Overall prevalence of serum zinc below the 2.5 percentile was 23% compared to 2% from National Health and Nutrition Examination Survey II (NHANES) data. Additionally, mean serum copper was significantly lower than NHANES II data. Mean energy intake was comparable to mean Estimated Energy Requirement (EER) based on the age, gender, height, weight and physical activity of subjects. In addition, mean dietary intake of Low Nutrient Density foods was not significantly different from NHANES II data and there was no significant difference in energy intake or the proportion of daily energy from protein, fat, and carbohydrate than what is observed from CCHS data. Medication treatment for ADHD was not associated with altered dietary intake or nutrient status. Conclusion. Results are suggestive of low zinc status in ADHD.

No description available.

No description available.

I investigated the effects of continuous administration of fluoxetine, a serotonin reuptake inhibitor, on energy expenditure, body temperature, and thyroid and catecholamine metabolism during weight reduction using a very low calorie diet (VLCD, Optifast, 1757 kJ/day) followed by a balanced deficit diet (BDD, 5016 kJ/day). Fluoxetine (60 mg/day by mouth, n = 10) or placebo (n = 10) were administered during 3 weeks of inpatient VLCD followed by 8 weeks of outpatient BDD in a double-blind, randomized design. A similar amount of weight was lost in both groups during the VLCD, but by the end of the BDD total weight loss in the fluoxetine group was significantly greater (11.0 $ pm$ 1.1 kg vs. 7.0 $ pm$ 1.0 kg, mean $ pm$ SEM, p $<$ 0.015). Resting metabolic rate (RMR) increased by 4.4 $ pm$ 1.8% (p $<$ 0.01) in the fluoxetine group but did not change in the placebo group during the first week of the VLCD, but subsequently decreased significantly in both groups as dieting continued. However, RMR remained consistently higher in the fluoxetine group for the duration of the VLCD period. No further change in RMR occurred in either group during the BDD period. The thermic effect of food did not change after VLC dieting plus fluoxetine or placebo treatment. Body temperature increased within 2 days of fluoxetine treatment by a mean of 0.3$ sp circ$C, p $<$ 0.025 and remained elevated throughout the VLCD but was unchanged in the placebo group. VLCD therapy reduced serum levels of T$ sb3$, free T$ sb3$ Index and 24-hour urinary excretion of dopamine, norepinephrine, metanephrine and normetanephrine equivalently in both groups. A thermogenic effect of fluoxetine is demonstrated in humans for the first time. The anorectic effect of fluoxetine may be related to its temperature elevating effect.

Smoking cessation leads to weight gain but the reason for this gain is not clearly established. The objective of this study was to compare the mean change in dietary intake among quitters and non-quitters enrolled in a smoking cessation program. Mean dietary intake was measured using 24-hour recall over the telephone at baseline and 6 weeks after the scheduled 'quit date'. Baseline data were obtained from 177 subjects and 130 (73%) were recontacted with complete data. There were 47 quitters (27%). The mean self-reported weight gain among the quitters and non-quitters was 2.4 kg +/- 3.1 and 0.04 kg +/- 2.5 respectively (p = 0.001). Mean energy intake was the same at baseline between the quitters and non-quitters. There were statistically significant changes in dietary intake between quitters and non-quitters. Given the high within-individual variability (sd 832) this sample size was only sufficient to detect differences in the change in intake of approximately 460 kcals between quitters and non-quitters.

In common with other expatriate Indian Populations, the Indian community of South Africa has a high incidence of coronary heart disease (CHD). Little information is available on the effects of exercise and diet on risk factors in this group. The present study is directed at the functional changes occurring as a result of a moderate aerobic physical activity programme, comprising 30 minutes of supervised exercise, three times per week for 15 weeks. Healthy male volunteers were recruited from the staff of the University of Durban-Westville, who were not on any lipid lowering medication and were not involved in any programme of physical activity for at least 12 weeks before the start of the project. The 41 subjects were assigned into one of three groups: exercise only (E) (15 subjects); exercise and diet (ED) (14 subjects) and a control (C) (12 subjects) group on no intervention. Besides laboratory investigations all participants were subjected to standardized fitness and anthropomorphological evaluation, a brief family history for coronary artery disease and a detailed dietary history was compiled. Baseline lipid results indicate that only 7 of the 41 subjects had normal lipid profiles using as cut-off points 5.2 mmol/l for cholesterol, 1.5 mml!l for triglyceride and 0.9 mmol/l for HDL-C. Obesity was moderately prevalent before intervention, with a mean decrease of 25% in body fat in both E and BD groups(p~0.05). The experimental subjects became leaner. After the intervention programme an average 20 percent increase was evident in physical working capacity as measured by peak V~ in both experimental groups (p~0.01). The controls showed little variation over the 15 weeks. The indices of muscular endurance and flexibility showed statistically significant changes (P~ 0.05) in both experimental groups after intervention. This certainly indicates elevated levels of fitness after the intervention. The lipid profiles show little alteration in total cholesterol, with a 7.3% decrease in triglyceride levels in the E group (which was not statistically significant) compared with a 14.7% increase in the controls. HDL-C showed an increase in both experimental groups (p~0.01). The total cholesterol to HDL-C ratio had an average fall of 11.9% in the experimental groups (P~0.05) compared with a 5.6% decrease in the control group. These data support the claim that regular, moderate exercise reduces the risk of heart disease through its effects on coronary risk factors in a high risk South African population. / Thesis (Ph.D.)-University of Durban-Westville, 1995.

The often stated inability of many patients to lose weight or maintain weight reduction is a common complaint heard in general practice and the dietary reasons underlying the problem was studied. The study was carried out in a suburban general practice , and it was found that there is a high degree of dietary ignorance and dietary indiscretion in overweight people. This would therefore account in the majority of cases for the claims made by patients that they eat very little and yet cannot lose weight. Overweight/obesity is of multi-factoral aetiology and the dietary aspect plays a major role. Thus recommendations have been made to endeavour to correct the problem at general practice level, by supplying a protocol in an approach to weight control management and at a community level by the introduction of a comprehensive and multifaceted health programme aimed at education and implementation of good dietary behaviour. / Thesis (M.Prax.Med.)-University of Natal, Durban, 1986.

The impact of habitually consuming a high protein (HP) diet at the upper limit of the acceptable macronutrient distribution range (AMDR) on kidney health is unknown. The current study was designed to test the hypothesis that long-term consumption of a diet providing 35% of energy as protein will have negative consequences on renal health, as assessed in a pig model. Methods: Adult female, non-pregnant, commercial pigs (Genesus) were randomized to receive either NP (15% energy from protein) or HP (35% energy from protein) isocaloric diets for either 4 or 8 months. Diets contained whole protein sources with an animal: plant ratio of 2:1 in the NP diet to mimic the average Canadian diet. The increased protein in the HP diet was achieved by increasing egg and dairy protein sources. Body composition was measured by dual-energy X-ray absorptiometry. Glomerular volume and kidney fibrosis were evaluated on kidney sections by quantitative image analysis. The inflammatory marker monocyte chemoattractant protein-1 (MCP-1) and the growth factor transforming growth factor beta-1(TGFβ1) were assessed in renal tissue using commercial ELISA kits. Results: Pigs given the HP diet had lower body weights and percentage of body fat. Pigs consuming the HP diet had significantly higher glomerular filtration rates (GFR) and larger kidneys. Renal MCP-1 levels and renal fibrosis also were significantly higher in pigs given the HP diet, while proteinuria and renal TGFβ1 expression did not differ. Conclusion: These findings suggest that, despite the potential benefit of the HP diet on body composition, long-term intakes of protein at the upper limit of the AMDR may compromise renal health in healthy female pigs.

Anticipatory satiety is the ability to reduce meal size when the diet at that meal is consistently followed by a short time interval to the next access to food. This prediction of intake is learnt, i.e. based on the association of a food's sensory characteristics with some consequence(s) of ingesting it. / Two pilot studies were conducted using male Sprague-Dawley rats in which (1) the ability of food texture to cue fasting duration was indicated by evidence of anticipatory satiety in the low-fat powder-long/paste-short group and in the high-fat paste-long/powder-short group and (2) the pattern of anticipatory satiety was seen only in the low-fat granules-long/powder-short group. / In the main experiment (n = 9), anticipatory satiety was reached twice in the highfat powder-long/pellet-short group on days 16--23 (p &le; 0.1) and once in the low-fat pellet-long group/powder-short on days 20--23 (p &le; 0.1). The acquisition of texture-cued fasting-anticipatory satiety seems to depend upon high-energy density of the diet and the utilisation of textures which make it easier for the rats to eat.