Given an n-vertex graph Gand two positive integers d, k is an element of N, the (d, kn)-differential coloring problem asks for a coloring of the vertices of G(if one exists) with distinct numbers from 1 to kn(treated as colors), such that the minimum difference between the two colors of any adjacent vertices is at least d. While it was known that the problem of determining whether a general graph is (2, n)-differential colorable is NP-complete, our main contribution is a complete characterization of bipartite, planar and outerplanar graphs that admit (2, n)-differential colorings. For practical reasons, we also consider color ranges larger than n, i.e., k > 1. We show that it is NP-complete to determine whether a graph admits a (3, 2n)-differential coloring. The same negative result holds for the (left perpendicular 2n/3 right pendicular, 2n)-differential coloring problem, even in the case where the input graph is planar.