Along with the rapid development of industrial and commercial industries, the extent of disasters in Kaohsiung city in recent years due to highly concentrated population, newly erected skyscrapers and factories is far beyond one's imagination. By using the Kaohsiung Emergency Operation Center (KEOC) as an example, this study investigates practical operations, including disaster prevention, disaster emergency action, restoration and reconstruction after disaster, etc., of the emergency operation center at a special municipality level. Methodologies utilized in this study include literature review, direct observation, questionnaire survey, and statistical analysis by using the SPSS software package for Windows (Version 8.0). Main conclusions of this study are summarized as follows: 1. The regional plan for disaster prevention and response needs to be specified. 2. Manpower for disaster prevention and response of Kaohsiung city needs to be increased and the duties need to be specified. 3. Budgets for disaster prevention and response need to be prepared liberally. More equipments and devices for disaster prevention and response need to be purchased. 4. Personnel training, exercise and teamwork/cooperation for disaster prevention and response should be conducted seriously. 5. Persuade the public that prevention is better than rescue. 6. Actions for disaster prevention and response should be incorporated into the local communities. 7. Modern emergency operation centers need to be well constructed. 8. Data for disaster prevention and response need to be integrated and processed into useful information. 9. Set up standard operating procedures (SOP) for disaster rescue and crisis management. 10. Integration and utilization of volunteers for disaster prevention and response need to be institutionalized. 11. Task schedules need to be well controlled, supervised, and checked. Recommendations from this study are summarized as follows: 1. Set up short, medium, and long-term objectives properly for disaster prevention and response. 2. Set up a duty-oriented unit for disaster prevention and response according to the law. 3. It is more appropriate than the current organizational system to combine the KEOC and Rescue Command Center, Fire Bureau into one task force and fulfill the services at one site. 4. It is recommended that Kaohsiung city government should actively pursue the establishment of the Southern Stand-by Supporting Unit, Central Emergency Operation Center in Kaohsiung city . 5. Amend related laws and regulations for disaster prevention and response as soon as possible. All recommendations mentioned above provide not only Kaohsiung city, but other counties and cities as well, with valuable references pertaining to establishing and operating the most efficient emergency operation center.