Low back pain is a costly financial and loss of productivity societal issue. Although its aetiology is unclear, it has been associated with the intervertebral disc and its degeneration which has been thought to be caused in part by poor nutrition. In this thesis the caudal disc of skeletally mature equines is utilised as an animal model. Techniques such as x-ray, light imaging, histology and magnetic resonance imaging were employed to investigate the vascular and structural anatomy of the disc and its surroundings and the uptake of tracers within the disc tissue. A detailed study of the anatomy revealed similarities with the human disc. The equine disc consists of two distinct structural areas; a nucleus and annulus. The surrounding vascularisation is similar; a main anteriorly positioned artery, the median caudal artery splits and encircles the centre of the vertebral body providing nutrition to the vertebral body. Smaller vessels anastomose over the surface of the vertebral body. Within the vertebral body the vessels end in capillary terminations at the edge of the vertebral cartilage endplate. As in humans these terminations were seen to vary along the endplate with shape and density; the capillaries are densest and larger in the area next to the nucleus. The cartilage endplate itself was found to have a variable width; of between 0.16 mm and 0.33 mm being widest at the nucleus. The annulus was seen to consist of lamellar rings which had high collagen content. A marked difference between equines and humans found was the number and width of lamellae present; equines were found to have on average 5 lamellae with a width range of 140 10 1110 microns. The shape of the discs was also found to be different with equines having almost circular coccygeal discs which have a concave superior and inferior surface. The nucleus of the disc, unlike current literature was found to have local order. An important contribution to knowledge which this thesis has made is data collected on diffusion time and partition coefficient on many regions within the disc. It was found that to reach equilibrium it took up to 22 hours in the outer anterior annulus but only 5 ½ hours in the central nucleus. Diffusion was found to be fastest with the neutral ring-shaped molecule Gadovist and slowest in the positive ion, manganese. Partition coefficients between the tracers were also found to vary. The highest partition coefficient was 6 in the central nucleus with manganese and the lowest was 0.5 with Magnevist at 0.5 in the nucleus area. This information will be useful in aiding drug delivery clinically and performing contrast enhanced imaging for pathology detection.

Ophthalmic diseases such as glaucoma are associated with progressive changes in the structure of the optic disc (OD) and parapapillary atrophy (PPA). These structural changes may therefore have relevance to other systemic diseases. The size and location of OD and PPA can be used as registration landmarks for monitoring changes in features of the fundus of the eye. Retinal vessel evaluation, for example, can be used as a biomarker for the effects of multiple systemic diseases, or co-morbidities. This thesis presents the first computer-aided measuring tool that detects and quantifies the progression of PPA automatically on a 2D retinal fundus image in the presence of image noise. An automated segmentation system is described that can detect features of the optic nerve. Three novel approaches are explored that extract the PPA and OD region approximately from a 2D fundus image. The OD region is segmented using (i) a combination of active contour and morphological operations, (ii) a modified Chan-Vese algorithm and (iii) a combination of edge detection and ellipse fitting methods. The PPA region is identified from the presence of bright pixels in the temporal zone of the OD, and segmented using a sequence of techniques, including a modified Chan-Vese approach, thresholding, scanning filter and multi-seed region growing methods. The work demonstrates for the first time how the OD and PPA regions can be identified and quantified from 2D fundus images using a standard fundus camera.

An important part of automobile safety is the braking system. Disc brakes have been widely used in automobiles for sped retardation for over 30 years. During that time, they have developed from a simple disc to a complex disc with channels, vanes, holes and grooves. The stopping capability of disc brakes is affected by the rate at which heat is dissipated by forced convection and the thermal capacity of the rotor. Catastrophic failure of brake rotors can occur during rapid increases or decreases in rotor temperature where regions of high temperature gradients result in high thermal strains. There is little information in the public domain regarding the relative merits of different disc brake rotor geometries, particularly in terms of airflow patterns, heat transfer rates, and internal thermal gradients. The aim of this research project was to investigate how geometrical variations affect the thermal performance of bi-directional disc brake rotors, particularly for high performance applications. Dynamometer testing showed that respectable increases in braking performance are achievable with relatively simple machining modifications. Tuft and smoke visualization techniques provided a preliminary understanding of the airflow in the passages of three distinct bi-directional rotor designs. Particle Image Velocimetry was used for detailed flow measurements which supported the numerical simulations. Computational Fluid Dynamics was used to predict the airflow and heat transfer associated with eight bi-directional brake rotor designs. The results show that 'pillared' passage designs can achieve higher heat transfer rates than traditional straight radial vane designs and that the heat loss from pillared rotors is generally more uniform than from vaned rotors. Subsequent conjugate heat transfer simulations found that temperature gradients inside pillared rotors are typically lower than inside vaned rotors. Thus failure rates due to excessive thermal strain are expected to be lower for pillared rotors. It was shown that rotor selection based solely on heat transfer rates is inappropriate and different passage designs are suited to different applications. The findings of this research will directly benefit local disc brake manufacturers, who do not have resources to conduct thorough studies comparing the thermal characteristics of different brake rotor designs.

Background: Disc herniations are common and have been demonstrated as one potential source of low back pain. To date epidemiological studies have found associations between lifting, lifting and twisting and twisting with increased risk in the development of disc herniations (Greenough and Fraser, 1994, Kelsey et al., 1984, Mundt et al., 1993). Subsequent, in vitro investigations were able to produce disc herniations through repeatitive flexion extension motions on cervical porcine functional spinal units (Callaghan and McGill, 2001). However, in vitro investigations on axial torque have drawn mixed conclusions and controversy remains on the role it plays with respect to disc herniations (Farfan et al., 1970, Adams et al., 1981). Therefore, the work in this thesis was to investigate the role of dynamic axial torque on the disc herniation mechanism. Methods: Porcine cervical spines were used as they are a good approximation to the human lumbar spine (Yingling et al., 1999). The study design involved repetitive flexion extension motions of the spinal units either preceded or followed by dynamic axial torque. During axial torque the spinal units were loaded to 17.5 Nm (standard deviation = 0.5 Nm) of dynamic axial torque for either 2000 or 4000 testing cycles. These spinal units were compared to spinal units that were loaded in repetitive flexion extension motions only and axial torque only. The spinal units were tested in a servohydraulic dynamic testing machine, combined with a custom jigs which allowed loading in flexion/extension, axial torque and compression. Plane film radiographs with contrast in the nucleus were obtained at regular intervals during and following the mechanical testing. Final dissection determined the disc injury patterns. Results and Discussion: Examination of the sectioned intervertebral discs indicated axial torque in combination with repetitive flexion extension motions, regardless of order, encouraged radial delamination. While, repetitive flexion extension motion alone encouraged posterior or posterolateral herniation patterns. Axial torque alone was unable to initiate a disc herniation. There was an increase in both rotation and stiffness of the intervertebral disc in response to repeated axial torque. There were no differences in rotation and stiffness between the groups. Both x-ray images and computed tomography scans were equally as good at identifying posterior or posterolateral herniations but were not good at detecting radial delamination.

Background: Disc herniations are common and have been demonstrated as one potential source of low back pain. To date epidemiological studies have found associations between lifting, lifting and twisting and twisting with increased risk in the development of disc herniations (Greenough and Fraser, 1994, Kelsey et al., 1984, Mundt et al., 1993). Subsequent, in vitro investigations were able to produce disc herniations through repeatitive flexion extension motions on cervical porcine functional spinal units (Callaghan and McGill, 2001). However, in vitro investigations on axial torque have drawn mixed conclusions and controversy remains on the role it plays with respect to disc herniations (Farfan et al., 1970, Adams et al., 1981). Therefore, the work in this thesis was to investigate the role of dynamic axial torque on the disc herniation mechanism. Methods: Porcine cervical spines were used as they are a good approximation to the human lumbar spine (Yingling et al., 1999). The study design involved repetitive flexion extension motions of the spinal units either preceded or followed by dynamic axial torque. During axial torque the spinal units were loaded to 17.5 Nm (standard deviation = 0.5 Nm) of dynamic axial torque for either 2000 or 4000 testing cycles. These spinal units were compared to spinal units that were loaded in repetitive flexion extension motions only and axial torque only. The spinal units were tested in a servohydraulic dynamic testing machine, combined with a custom jigs which allowed loading in flexion/extension, axial torque and compression. Plane film radiographs with contrast in the nucleus were obtained at regular intervals during and following the mechanical testing. Final dissection determined the disc injury patterns. Results and Discussion: Examination of the sectioned intervertebral discs indicated axial torque in combination with repetitive flexion extension motions, regardless of order, encouraged radial delamination. While, repetitive flexion extension motion alone encouraged posterior or posterolateral herniation patterns. Axial torque alone was unable to initiate a disc herniation. There was an increase in both rotation and stiffness of the intervertebral disc in response to repeated axial torque. There were no differences in rotation and stiffness between the groups. Both x-ray images and computed tomography scans were equally as good at identifying posterior or posterolateral herniations but were not good at detecting radial delamination.

This objective of this thesis is to establish the whole structure for optimal efficiency operations of a disc permanent magnet linear synchronous machine (DPMLSM) based on a digital signal processor (DSP). The thesis is to present the derivation algorithm and strategy of achieving optimal efficiency operations. To fulfill the operational requirements the theoretical basis and experimental database will first be developed, along with the constructions of adequate digital processor-base control and peripheral circuits. Hence the appropriate trigger angles of machine stator phase windings can be advised, and the control objectives of the DPMLSM under steady-state as well as dynamic conditions can be achieved.

No description available.

No description available.

Recent developments of electro-hydraulic disc valves at Surrey University have shown that with a careful balance between the hydraulic and magnetic forces, this type of valve can be used as a digital or proportional device. As the valve is simpler in construction and involves very few critical dimension compared with a servo-valve, the sensitivity to contamination is considerably reduced. The dynamic response of the valve is fast due to utilising high electro-magnetic and fluid forces for actuation. The research described in this thesis is an extension of earlier work by Yuksel and Usman to improve electro-hydraulic disc valves by applying closed-loop position or pressure control to the disc. From an investigation of an unbalanced single disc valve, it was found that using position feedback can help to stabilise the disc under varying load conditions. A special differential capacitive transducer to measure the disc position was designed and constructed and was found to perform satisfactorily. As the pressure-flow characteristic of the valve can be varied by controlling the disc position, the function of the valve is similar to an electrically controlled variable orifice. Various modular configurations are proposed to perform more complicated control functions. In the final part of the research, a double disc valve is described for used in an application study to control the damping characteristic of a modified vehicle shock absorber. Initially, the valve was designed for closed-loop position control due to the non-linear hydraulic and magnetic forces. Results show that the valve can be controlled to generate the required range of damping force and has adequate dynamic performance with a response time in the range of 10 to 30 msec. However, tests using direct pressure control were also carried out. Preliminary results indicate that pressure feedback is preferable to position feedback and that by using lead compensation together with a proportional plus integral controller, stable operation is possible.

No description available.