In the present study / ten autosomal human-specific Alu insertion polymorphisms / ACE, APO, A25, B65, D1, FXIIIB, HS4.32, HS4.69, PV92 and TPA25 were analyzed in approximately 100 unrelated individuals from Anatolia. Alu insertion polymorphisms offer several advantages over other nuclear DNA polymorphisms for human evolution studies. The frequencies of the ten biallelic Alu insertions in Anatolians were calculated and all systems were found to be in Hardy-Weinberg equilibrium (p&gt / 0.05). By combining the results of this study with results of previous studies done on worldwide populations, the genetic distance (Nei&rsquo / s DA) between each pair of populations was calculated and neighbor joining trees were constructed. In general, geographically closer populations were found to be also genetically similar. Principal component analysis (PCA) was performed and Anatolia was found to be in the European cluster. As a result of PCA / it was concluded that FXIIIB, PV92 and ACE were the variables contributing the most to the explanation of the variation between the populations. Additionally / canonical variates analysis (CVA) concluded that the most discriminative markers for the groups of populations were PV92, D1, ACE and HS4.32. Pair-wise Fst values were also calculated between Anatolians and some of the populations for which the data was available. It was concluded that, Anatolians have non-significant pair-wise Fst values with Swiss and French Acadian populations. Lastly, heterozygosity vs. distance from centroid graph was constructed and it was found that Anatolians and India-Hindu had exactly the expected heterozygosity value predicted by the model of Harpending and Ward (1982).

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This diploma thesis deals with the analysis of experimental electrograms (EG) recorded from isolated rabbit hearts. The theoretical part is focused on the basic principles of electrocardiography, pathological events in ECGs, automatic classification of ECG and experimental cardiological research. The practical part deals with manual classification of individual pathological events – these results will be presented in the database of EG records, which is under developing at the Department of Biomedical Engineering at BUT nowadays. Manual scoring of data was discussed with experts. After that, the presence of pathological events within particular experimental periods was described and influence of ischemia on heart electrical activity was reviewed. In the last part, morphological parameters calculated from EG beats were statistically analised with Kruskal-Wallis and Tukey-Kramer tests and also principal component analysis (PCA) and used as classification features to classify automatically four types of the beats. Classification was realized with four approaches such as discriminant function analysis, k-Nearest Neighbours, support vector machines, and naive Bayes classifier.

Cílem mé diplomové práce bylo navrhnout metodu analýzy retinálních sekvencí, která bude hodnotit kvalitu jednotlivých snímků. V teoretické části se také zabývám vlastnostmi retinálních sekvencí a způsobem registrace snímků z fundus kamery. V praktické části je implementována metoda hodnocení kvality snímků, která je otestována na reálných retinálních sekvencích a vyhodnocena její úspěšnost. Práce hodnotí i vliv této metody na registraci retinálních snímků.