Selenium, the essential trace element, is well known as its antioxidant function, antiviral properties, and its anti-inflammatory function to human health. The relationships between selenium status and diabetes mellitus have been widely studied, but the consistency of results is lacking. This study used diagnosed diabetes incidence from year 2004 to 2012 and soil selenium content by counties within 48 contiguous states in the U.S. with Generalized Linear Mixed Model- R-Side as the major statistical method to determine whether there is a significant correlation or not. Results showed that the diagnosed diabetes population had been increased from 2004 to 2012 for all 48 states. The South region showed the highest increased rate whereas the Northeast region showed the least. Also, Kentucky, Louisiana, Maryland, and Massachusetts are the four states showed the significant correlation between soil selenium content and diabetes incidence. However, improved analytical methods and data are needed for further research.