There has been little scientific work exploring eating pathology among Jewish women in the United States, even though research has suggested that body image and eating behavior may be especially problematic within this group. Research has also demonstrated the importance of religion in eating pathology, such that extrinsic religiousness may represent a vulnerability mechanism, whereas intrinsic religiousness may act as a protective factor against disordered eating. Thus, the current study examines the association between religion and disordered eating among Christian (n = 145) and Jewish Caucasian (n = 73) women. The role of culture was also explored among Jewish women. All participants completed self-report questionnaires at Time 1 and then six weeks later at Time 2. Jewish and Christian women had comparable levels of disordered eating and body dissatisfaction. Results revealed that neither extrinsic religiousness nor intrinsic religiousness predicted disordered eating among the Jewish group. Hypotheses regarding religious motivation and religious adherence were partially supported among the Christian group. These findings highlight that Allport and Ross’s religion framework may not be appropriate for use with Jewish female samples. Similarly, identifying with Jewish culture did not predict disordered eating. As a whole, these findings emphasize the striking need for more empirical data on what does contribute to a Jewish woman’s vulnerability to eating disorder symptoms.

Disordered states of proteins include the biologically functional intrinsically disordered proteins and the unfolded states of folded proteins which are important for protein folding and stability. Just as solving the structures of folded proteins has been extremely valuable in understanding their functions and properties, obtaining a comprehensive understanding of the structural characteristics of disordered states at a molecular level is crucial. The focus of this thesis is on combining experimental data with computational methods in order to probe the structural characteristics of disordered states at a molecular level. I developed a new method that combines different chemical shifts into a single residue-specific secondary structure propensity (SSP) score which I used to compare fractional secondary structure in alpha- and gamma-synuclein. Significant differences between the two suggested that gamma-synuclein might be protected from fibrillation due to increased helical propensity. I also introduced a new method for calculating residual dipolar couplings (RDCs) from disordered state ensembles by calculating local alignment tensors for short protein fragments. Using this method, I was able to predict experimental RDCs from statistical coil models containing far fewer structures than when global alignment is used, demonstrating that RDCs in disordered proteins are primarily determined by local structure. Finally, I made major improvements to the ENSEMBLE program which is used for calculating structural models of disordered states. I utilized large amounts of experimental data in order to calculate ensemble models of the Drosophila drkN SH3 domain unfolded state. Although highly heterogeneous and having broad molecular size distributions, the calculated ensembles have very different properties than expected for random or statistical coils and possess significant non-native alpha-helical structure and both native-like and non-native tertiary structure. This has significant implications for our understanding of the structural properties of protein disordered states in general.

Thesis PlanB (M.S.)--University of Wisconsin--Stout, 2009. / Includes bibliographical references.

Eating disorders are among the most common clinical manifestations in children, and they are frequently connected with maternal psychopathological risk, internalizing/externalizing problems in children, and poor quality of mother–child feeding exchanges. During the COVID-19 lockdown, in person assessment and intervention were impeded due to the indications of maintaining interpersonal distancing and by limits to travel. Therefore, web-based methods were adopted to meet patients’ needs. In this study N = 278 participants completed the SCL-90/R and the CBCL to examine the psychopathological symptoms of mothers and children (age of the children = 24 months); moreover, the dyads were video-recorded during feeding and followed an online video-feedback based intervention. Maternal emotional state, interactive conflict, food refusal in children, and dyadic affective state all improved considerably, as did offspring internalizing/externalizing problems and mothers’ depression, anxiety, and obsession–compulsion symptoms. This study showed that video-feedback web-based intervention might be employed successfully to yield considerable beneficial effects. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Salt-affected soil is a prominent challenge in agriculture. Nowadays, more than 800 million hectares of land (about 6% of the world’s total land area) are induced with high salt concentrations, and thus, are unsuitable for growing typically salt-sensitive crop plants. The ongoing salinization of arable land exacerbates this limitation. To address this issue, the development of salinity-tolerant crop plants has gained considerable interest, with a protein identified by Prof. Mark Tester's group, named "SALTY2," offering promising potential. SALTY2 is overexpressed in response to NaCl treatment on Salicornia plants conferring salinity tolerance, and following the function of the SALTY2 protein from Salicornia and analogous proteins in Arabidopsis, yeast and in vitro, a universal mechanism in evolution is suggested. During my thesis, we analyzed the biophysical properties of SALTY2, and based on spectroscopic methods we confirmed it is an intrinsic disordered protein (IDP), which is consistent with previous studies claiming that IDPs play a vital role in stress response pathways. We have identified and characterized the loss-of-function "RG/RGG" to "KG/KGG" type mutation and a deltaSTM1 N-terminal mutation, and investigated the interaction of SALTY2 and other cellular components, including short fragment RNA, and 80S ribosome. Together with state-of-the-art high-resolution NMR and Cryo-EM methods we validated the direct interaction of SALTY2 with plant ribosomes, and 25nts random RNA, and determined the 3D structure of ribosome with the potential binding site of the SALTY2 protein. Combining biophysical, structural and functional analyses of the wild-type and loss-of-function mutants of SALTY2, we proposed a potential mechanism by which the IDP protein SALTY2 confers salinity tolerance in plants. These findings offer a deeper understanding of the molecular basis of salinity tolerance in plants via IDPs and contribute to the ongoing efforts to develop salinity-tolerant crop plants.

In Part 1 of this thesis the interaction of personality variables in predicting risk of disordered eating is examined. Shyness and an interaction between neuroticism and introversion were found to increase risk of disordered eating in independent university samples. These findings highlight a potential genetic susceptibility to eating pathology by demonstrating similar personality vulnerabilities in clinical eating disorders, as in nonclinical disordered eating. However, the implications and generalizations that can be drawn from these first two studies are limited by the equivocal relationship between disordered eating and eating disorders. Part 2 of the thesis examines the continuum theory of eating disorders. A theoretical hypothesis is introduced and offers a framework for thinking of thoughts separate from behaviours. Through a review ofexisting literature, it is noted that eating disorder thoughts are far more prevalent than the behaviours, and while the thoughts can occur independent of the behaviours, behaviours are necessarily tied to pathological thoughts. Preliminary empirical support for this hypothesis is presented by modeling eating disorder thoughts and behaviours as distinct latent constructs in a confirmatory factor analysis using data from a large sample of university females. Frequency analyses of eating disorder thoughts and behaviours offered support for the argument that eating disorder symptoms are not normally distributed across non-clinical settings. As predicted, thoughts occurred independent of the behaviours, and behaviours occurred only in conjunction with thoughts. The interaction of eating disorder thoughts with eating disorder behaviours provided the most robust predictor of psychopathology, although the relative contribution of thoughts and behaviours to psychopathology was not equivalent. These results were replicated in a national epidemiological sample offemales ages 15 to 34 years, and the findings were consistent with results from the university sample. Behaviours were more consistently associated with psychopathology in both the university sample and the national sample. The contribution of this thesis to the field of epidemiological research in eating disorders is through the recommendation that screening instruments use behaviours to identify cases and a high threshold of thoughts in risk assessment. / Thesis / Doctor of Philosophy (PhD)

Thesis PlanB (M.S.)--University of Wisconsin--Stout, 2009. / Includes bibliographical references.

Thesis (Ed. D.)--Illinois State University, 1996. / Title from title page screen, viewed May 25, 2006. Dissertation Committee: Ming-Gon John Lian (chair), Jeff Bakken, Thomas E. Caldwell, Kenneth H. Strand, Mark E. Swerdlik. Includes bibliographical references (leaves 94-106) and abstract. Also available in print.

published_or_final_version / Community Medicine / Master / Master of Public Health

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