Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2004. / "June 2004." / Includes bibliographical references. / As economies grow and companies seek increasing market shares, they must also build the infrastructure within their organization to support that growth. In the grocery business in particular, there are many challenges associated with fleet management and the opportunity to centrally manage the entire fleet is viewed as a cost and time-savings opportunity. This project was conducted in partnership with a grocery retailer with the goal of examining several elements of the companies transportation system and processes with two goals in mind. The first goal was to look for opportunities to reduce cost, total miles traveled, and total empty miles traveled by the fleet. The second goal was to examine current processes and start to determine what changes or approaches should be recommended in pursuit of a central dispatching function to coordinate all movements within the transportation network. For this particular retailer, several areas were identified as potential stepping stones in its plan to begin a central dispatching operation. These areas of opportunity include using third party carriers for store deliveries, planning routes to increase the level of coordination between inbound and outbound transportation, and using the retailer's private fleet to provide carrier service for other shippers. Analysis projected that using third party carriers for outbound store deliveries could save the organization a significant sum of money, more than 1% of annual freight costs. Overall, there are many opportunities to take advantage of network characteristics to improve overall efficiency, reducing total cost and total empty miles traveled; they are discussed in detail. / by Nancy June Archambault. / M.Eng.in Logistics

Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2011. / Cataloged from PDF version of thesis. / Includes bibliographical references (p. 95-98). / Electric (EV) and Plug-in Hybrid Electric vehicles (PHEV) continue to gain attention and market share, not only as options for consumers but also for corporate fleets. EVs and PHEVs can contribute to lower operating costs through reduced maintenance requirements and enhanced fuel economy. In addition, a fleet of EVs or PHEVs, when parked and aggregated in a sizeable number, can provide regulation services to the grid through the electricity stored in the vehicle's batteries. This opportunity is known as Vehicle-to-grid technology (V2G). This thesis evaluates the economics for V2G-enabled fleets to participate in the regulation services market. In order to build a business case for fleet managers, we constructed a 10-year cash flow model that compares the operating, infrastructure, and capital costs, as well as the revenue opportunities for EVs, PHEVs, and ICEs. To quantify potential revenues, we adapted a tool that the ISO New England has used to simulate the revenues of participants in the regulation market for an alternative energy pilot. We show that ICEs, while having the lowest retail value, actually have the greatest NPV due to their high operating costs and inability to participate in the regulation services market. EVs have the highest retail value, but due to their large battery size are able to provide the most regulation services. The opportunity for V2G is critical for the attractiveness of the EV. PHEVs offer lower V2G revenue opportunity than the EVs but have greater operational flexibility. We determined that V2G revenue potential is driven by the charger capacity and battery size and there are tradeoffs associated with these components. A larger battery and charger will generate more money from regulation services, but their high investment cost may outweigh these benefits. The correct combination of charger capacity, battery size, and state of charge (SOC) is important. If the charger capacity is too large and SOC too high or low, a small battery can be charged or depleted too quickly, hindering its ability to provide regulation services. / by Andrés De los Ríos Vergara and Kristen E. Nordstrom. / M.Eng.in Logistics

Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2007. / This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections. / Includes bibliographical references (leaves 74-76). / This thesis looks at two back-to-back disruptive supply chain events, one due to a sole-supplier's bankruptcy and the other caused by Hurricane Rita, that occurred at a specialty chemical company, and uses these examples to demonstrate how managing crises is more costly than managing risks. In examining the events surrounding the sole-supplier bankruptcy, managing a crisis cost this specialty chemical company 45% more money than managing a risk. Through the findings of these two disruptive events, a framework, the Eye of Providence, is created to manage supply chain risks. First, an organization must determine how developed its risk-management protocol is. Next, by studying past disruptive events and determining the key impact factors, an organization could calculate and learn about the opportunity cost of managing crisis. Then, by continuously evaluating its suppliers and rigorously applying those key impact factors to the analysis of its supply chain practice, an organization could evaluate and identify its current vulnerabilities. / (cont.) Finally, by proactively monitoring event-based warning signals, or disruption indicators, an organization could assess its potential supply chain risks, and plan accordingly. Whether a company is low on the risk-maturity level or has already integrated risk management into its corporate culture, the process developed in this thesis serves as a versatile tool that can help businesses structure a more dynamic, resilient supply chain. / by Garrett J. Lee [and] Zen-Lee M. Chang. / M.Eng.in Logistics

Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2007. / Includes bibliographical references (leaves 54-55). / With the globalization of industries since the 1980's, logistics parks have emerged as a solution for the consolidation of operations and logistics services for global companies. In the beginning, logistics parks were limited to enabling companies to centralize their operations using shared warehousing and transportation infrastructures; however, these logistics parks now additionally offer a range of value-added services to enhance the supply chain. Most of these logistics parks were developed in the past decade, and there is little research on these facilities and the value-added services they are providing. The impact of these services on the global supply chain is also not well understood. Managers of logistics parks from around the world were interviewed and surveyed about the general infrastructures at their parks, and about the value-added services they provide for the companies operating at their facilities. Elements of the physical infrastructure and value-added services were grouped and ranked based on their impact on supply chains, and attractiveness to customers. / (cont.) The physical location and infrastructure of these facilities represent the most important factors in selecting logistics parks; however, other value-added services are gradually gaining importance and attractiveness due to increasing customer requirements and supply chain complexities. To cope with this change, logistics parks must carefully select the value-added services that are the most attractive to their customers, and which have the most positive impact on their supply chains. / by Ali El Amrani. / M.Eng.in Logistics

Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2010. / Cataloged from PDF version of thesis. / Includes bibliographical references (p. 143-148). / In retail delivery companies, packaging is used to transport goods to customers while preventing damage, shrinkage and loss of the contents. With consumer preferences reflecting the growing concern for the environment, retail delivery businesses are at the crossroads of implementing a sustainable operational and financial business model of delivering packages to customers. In this thesis, we will address the issue of sustainable packaging in retail delivery companies by evaluating the financial, environmental and operational viability of such strategies. The thesis will be limited to the downstream order fulfillment cycle from the retail delivery company to the customer. We will focus on three areas applicable to sustainable packaging. The first area is materials innovation where we will analyze alternative materials suitable for retail delivery packaging. The second area involves waste elimination through reducing packaging material use and reusing of packaging materials through a returnable tote program. Lastly, we will understand the implementation challenges to increase the success rate of the strategies mentioned earlier. / by Joshua Ng and Kendall Chow. / M.Eng.in Logistics

Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2006. / Leaf 64 blank. / Includes bibliographical references (leaves 60-63). / In recent years, China has become the world factory for a sizable portion of products. Most manufacturing conglomerates in the United States now have contract manufacturing plants in China. Because many of these US companies have implemented a variety of inventory reduction approaches, they are now faced with the expensive transportation of large numbers of low-weight, small- quantity shipments in international inbound transportation, transportation that covers the flows of goods from contract manufacturers (CMs) in China to original equipment manufacturers (OEMs) in the States. While there has been research on consolidation, little attention has been paid to international inbound freight consolidation, which provides a potential savings opportunity in international transportation by combining several small shipments into one large shipment. This paper examines how manufacturers in the United States can use freight consolidation in their international inbound transportation flow from CMs in China. It then explores a framework for designing inbound consolidation, focusing on how to implement inbound consolidation in the context of China's fast-evolving logistics industry. / by Yi Fang. / M.Eng.in Logistics

Thesis: M. Eng. in Logistics, Massachusetts Institute of Technology, Engineering Systems Division, 2015. / Cataloged from PDF version of thesis. / Includes bibliographical references (pages 71-72). / This thesis focuses on the study of the carrier-shipper relationships in the US trucking market. It uses data provided by a leading third party logistics (3PL) company to explore and determine whether a relationship exists between the prices charged by the carriers and the performance that they provide to the shippers. The performance metrics defined in the thesis are measured in three dimensions: on time pick-up, on time delivery, and acceptance ratio. The research uses ordinary least square (OLS) regression to study the effect of the performance parameters on the cost per load of a shipment. The research demonstrates that there is a mild relationship between on time delivery performance and price. With increase in on-time delivery performance, the price increases till a threshold is reached, beyond which it stabilizes. We found that a relationship exists between on-time pick-up and delivery. Since carriers who pick up late are able to deliver on time 80% of the times, the research could not find a direct relationship between on-time pick-up and price. The research also found that increased lane loyalty from a shipper to a carrier can lead to lower rates. / by Nane Amiryan and Sharmistha Bhattacharjee. / M. Eng. in Logistics

Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2005. / "June 2005." / Includes bibliographical references (p. 40-43). / Traditional vaccines consisting of live attenuated pathogens or inactivated toxins cannot be readily applied to the more challenging diseases of the present e.g. hepatitis C and the human immunodeficiency virus. As such, there is a need to develop new methods of priming the immune system against such foreign invaders. Recombinant protein subunits and peptides are relatively safe alternatives to live attenuated pathogens. However, these antigens are poorly immunogenic when administered alone in solution form and thus require the use of an adjuvant. To this end, we have developed a hydrogel-based nanoparticulate system to encapsulate protein antigen and to co-deliver it with DNA/RNA-based adjuvants to dendritic cells, the key antigen presenting cells in primary immune responses. Using CpG oligonucleotides or siRNA as adjuvants, we observed via enzyme-linked immunosorbent assays for interleukin 12 and interferon-[alpha], respectively, that DCs were activated by CpG oligonucleotide- and siRNA-functionalized nanoparticles [approx.]10-fold more potently than by soluble CpG or siRNA ligands. / by Jonathan Woon Teck Yap. / M.Eng.

Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2012. / Cataloged from PDF version of thesis. / Includes bibliographical references (p. 92-96). / Insourcing and vertical integration often allow companies to gain competitive advantage by exercising a greater degree of control over their supply chain. In the case of ABC Oilfield Services, insourcing the transportation of their products to offshore oil rigs at sea - a function currently provided by their customers - will increase asset velocity of their most important tools, and allow them to service more customers with fewer tools. This is an especially important consideration in light of the fact that the offshore drilling market will see double-digit growth in the coming years. This paper examines the effect of such increased asset velocity on Return on Assets (ROA). Using detailed historical data of ABC shipments of their biggest revenue-generating tools, we modeled both the status quo logistics system of ABC, and an alternative system based on sound insourcing assumptions. We then compared the projected ROA of the two scenarios in order to gain insights into the relationship between insourcing and its likely effect on ROA. We attempt to quantify the asset velocity benefits of insourcing, but also show the surprising result that increased asset velocity can have a negative effect on revenue under common pricing schemes. While there may be several other factors which help in ultimately making the decision to insource, the paper provides an important contribution in helping decision makers see the effects of insourcing in the oilfield services industry more clearly, and identifying the conditions under which insourcing will have the biggest benefit to ROA. / by Devjit Ghose and Kevin Murphy. / M.Eng.in Logistics

Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2005. / Includes bibliographical references (p. 152-167). / Chondrocytes respond to in vivo mechanical loads by regulating the composition of the cartilage extracellular matrix. This study utilized three loading protocols that span the range of forces and flows induced by in vivo loading. Constant (static) compression of cartilage explants induces a transient hydrostatic pressure buildup and fluid exudation from the compacted matrix until relaxation leads to a new equilibrium compressed state. Dynamic compression induces cyclic matrix deformation, hydrostatic pressures, fluid flows, and streaming currents. Dynamic tissue shear causes cyclic matrix deformation only. After applying these loading protocols to intact cartilage explants for 1 to 24 hours, we used real-time PCR to measure the temporal expression profiles of selected genes associated with cartilage homeostasis. In concurrent experiments, we assessed the involvement of intracellular signaling pathways using molecular inhibitors. In order to interpret the results we developed two techniques that reliably clustered intermediate-sized datasets using principal component analysis and k-means clustering. Mechanical loading regulated a variety of genes including matrix proteins, proteases, protease inhibitors, transcription factors, cytokines, and growth factors. Static compression transiently upregulated matrix proteins, however, mRNA levels were suppressed by 24 hours. / (cont.) Dynamic compression and dynamic shear increased matrix protein transcription particularly after 24 hours. In contrast, matrix proteases were upregulated by all 24 hour loading regimes, particularly static compression. Taken together these results demonstrate the functionally-coordinated regulation of chondrocyte gene transcription in response to mechanical forces, and support the hypothesis that dynamic loading is anabolic for cartilage and static loading is anti-anabolic. Intracellular calcium release, cAMP activation of protein-kinase-A, and the phosphorylation of MAP kinases (ERK1/2, p38), were all identified as signaling events necessary for mechanically-induced transcription. In addition, we measured the immediate, transient increase in mRNA levels of transcription factors downstream of the MAP kinase pathway (c-Fos and c-Jun), in response to all three loading types. The prevention of protein synthesis during static compression suppressed mechanically-induced transcription suggesting that signaling molecules are synthesized in response to mechanical forces. Comparison of this well characterized model of normal cartilage mechanotransduction to what occurs within diseased cartilage will hopefully provide insight into the mechanisms driving the progression of osteoarthritis. / by Jonathan Basil Fitzgerald. / Ph.D.