Background: Animals have been shown to have a positive effect on people. The nursing science approach says that a person can experience well-being despite illness. The positive attributes of animals can be used in health care to help ill people experience well-being. An animal-assisted intervention can be a form of activity or therapy involving pets (AAA / AAT) or horses (EAT). Aim: The purpose of this study was to elucidate how animals in health care promote well-being for people with long-term illness. Methods: Literature review based on fourteen original scientific articles, with both qualitative and quantitative approach. Results: The compilation of the results led to four main categories with two subcategories respectively. These were: Physical aspects with subcategories Physical well-being and Bodily functions; Psychic aspects with subcategories Psychic well-being and Reduced psychiatric symptoms; Existential aspects with subcategories Quality of Life and Safety; Social Aspects with subcategories Social behavior and Relationships. Discussions: Review and discussion of the selected method. Discussion of the results with the selected theoretical framework: Antonovsky's theory of Sense of Coherence (SOC) and the salutogenic approach. The results were discussed based on the concepts of comprehensibility, manageability and meaningfulness.