Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-07-05T14:44:28Z No. of bitstreams: 1 EdilbertodosSantosBarrosDissertacacao2012.pdf: 1470664 bytes, checksum: e078323f3716ae1ad3491d28ce8fcfce (MD5) / Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-07-05T14:44:39Z (GMT) No. of bitstreams: 1 EdilbertodosSantosBarrosDissertacacao2012.pdf: 1470664 bytes, checksum: e078323f3716ae1ad3491d28ce8fcfce (MD5) / Made available in DSpace on 2017-07-05T14:44:39Z (GMT). No. of bitstreams: 1 EdilbertodosSantosBarrosDissertacacao2012.pdf: 1470664 bytes, checksum: e078323f3716ae1ad3491d28ce8fcfce (MD5) Previous issue date: 2012-04-17 / Background: The number of elderly (60 years or more) grows all over the world, for two reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular diseases, particularly atherosclerosis, are the major cause of death in the elderly people. Aging causes changes in the immune system that contribute to a higher incidence of infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines, represent a systemic chronic inflammatory state known Inflammation. In the elderly, the redistribution of tissue calcification is different from the predictive value of coronary artery calcification. Thus, the association of comorbidities caused by aging prevents the extrapolation of knowledge gained in younger populations. Main: To investigate the relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein (CRP) with coronary calcification in the very elderly. Materials and methods: Individuals aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by ultrasound and coronary artery calcification (CAC) by computed tomography. Results: There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06) or mean IMT (p = 0.2). No association was found between the presence of carotid plaques and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC (p = 0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10. Conclusion: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile. / Introdu????o: O n??mero de pessoas idosas (60 anos ou mais) cresce em todo o mundo, por dois motivos: aumento da expectativa de vida e redu????o das taxas de fertilidade. Por outro lado, as doen??as cardiovasculares, particularmente a aterosclerose, s??o a maior causa de morte, especialmente na popula????o idosa. O envelhecimento provoca altera????es no sistema imunol??gico que contribuem para uma maior incid??ncia de doen??as infecciosas e cr??nicodegenerativas. N??veis basais de citocinas aumentados, representam um estado inflamat??rio cr??nico sist??mico, chamado de Inflammaging. Na pessoa idosa, a redistribui????o da calcifica????o nos tecidos ?? distinta dos valores preditivos da calcifica????o das art??rias coron??rias. Desta forma, a associa????o de comorbidades provocadas pelo envelhecimento inviabiliza a extrapola????o dos conhecimentos adquiridos em popula????es mais jovens. Objetivo: investigar a associa????o entre n??veis s??ricos das citocinas: TNF- , IL-10 e Prote??na C Reativa (PCR) com a calcifica????o coronariana em pessoas muito idosas. Materiais e m??todos: Indiv??duos com idade entre 80 e 102 anos (n = 178). Foram avaliadas citocinas plasm??ticas, prote??nas de fase aguda, espessura ??ntima-m??dia (IMT), presen??a de placas nas art??rias car??tidas por ultrassom e calcifica????o da art??ria coron??ria (CAC) por tomografia computadorizada. Resultados: N??o houve associa????o entre CAC e placas carot??deas (p = 0,8), m??ximo (p = 0,06) ou m??dia IMT (p = 0,2). N??o foi encontrada associa????o entre a presen??a de placas carot??deas e PCR (p = 0,4), TNF- (p = 0,8) ou IL-10 (p = 0,2). Da mesma forma, os indiv??duos nos tr??s primeiros quartis de PCR, TNF- ou valores de IL-10 an??ncios similares de CAC e IMT m??ximo. Os valores de CAC e IMT m??ximo, foram associados positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima do percentil 75. Conclus??o: Em indiv??duos muito idosos, os valores de CAC e IMT m??ximo, foram associados positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima do percentil 75.