Using an analogue format, the present study evaluated the viability of relationship and interactional concepts that have been applied to the physician-patient interaction to the field of organ donation by examining the donation request process between procurement coordinators and simulated families. Interpersonal processes were assessed using behavioral ratings by independent observers. Procurement coordinators were viewed as being more submissive than dominant and more friendly than hostile. Family members were viewed as being more hostile than friendly, more dominant and hostile than submissive or friendly, disclosing slightly more personal information than medical information, and engaging in slightly more shared decision making than providing medical information. Procurement coordinator gender and ethnicity and family ethnicity influenced interpersonal behavior. Several interpersonal variables were associated with measures of the “decision to donate” obtained from raters and simulated families. Implications for the field of organ donation and the training of procurement coordinators are discussed.