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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
61

Verbal-Motor Behaviour in Adults With and Without Down Syndrome

Welsh, Timothy 10 1900 (has links)
Previous research has indicated found that individuals with Down syndrome (DS) have difficulties in processing auditory information for the planning of movements relative to their peers with undifferentiated developmental handicaps. This modality-specific information-processing difficulty has been found for the preprogramming of goal-directed aiming movements (Le Clair & Elliott, 1995) and in simple reaction times (Davis, Sparrow, & Ward, 1991; Hermelin, 1964). The purpose of the present study was to assess whether or not a model of atypical cerebral specialization for the perception of speech sounds, proposed by Elliott and colleagues, could explain these findings. Thus, participants performed a choice reaction aiming task under three conditions. Colour-coded targets were cued by a visual cue at the target location, a visual cue remote from the target location, or a verbal cue identifying the target. Results revealed that while the reaction times did nCit differ between the two groups with handicaps, the participants with DS, unlike the two control groups, had significantly longer movement times in the verbal than in two visual conditions. These results support the model of biological dissociation. / Thesis / Master of Science (MS)
62

A study of the effectiveness of an adaptation of melodic intonation therapy in increasing the communicative speech of young children with Down syndrome /

Carroll, Debbie. January 1996 (has links)
No description available.
63

Coping with a child with down syndrome: the experiences of mothers.

January 1997 (has links)
by Lam Lai Wah. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 121-128). / ACKNOWLEDGMENTS --- p.i / ABSTRACT --- p.ii / TABLE OF CONTENTS --- p.iv / LIST OF TABLES AND FIGURES --- p.vi / LIST OF APPENDICES --- p.vii / Chapter CHAPTER 1 --- INTRODUCTION --- p.1 / Chapter CHAPTER 2 --- LITERATURE REVIEW / Introduction --- p.5 / Parental reactions to the birth of a child with congenital disability --- p.6 / Introduction to Down syndrome --- p.7 / Parental stress in rearing a child with handicaps --- p.11 / Outcomes of parental stress --- p.13 / Variables in relation to parental stress --- p.15 / Lazarus and Folkman's theory of stress and coping --- p.17 / Coping resources --- p.18 / Studies on perceived stress --- p.20 / Studies on coping --- p.24 / Studies on coping resources --- p.29 / Maternal focus --- p.30 / Summary --- p.32 / Chapter CHAPTER 3 --- METHODOLOGY / Aim --- p.34 / Objectives --- p.34 / Design --- p.35 / Sample --- p.36 / Instrument --- p.37 / Ethical issues --- p.38 / Gaining access --- p.39 / Pilot study --- p.41 / Results of the pilot study --- p.42 / Data collection --- p.44 / Data analysis --- p.49 / Validity and reliability --- p.54 / Chapter CHAPTER 4 --- FINDINGS / Demographic characteristics of the mothers --- p.58 / Demographic and biographic characteristics of the children --- p.59 / Description of the major categories and sub-categories identified --- p.61 / Chapter CHAPTER 5 --- DISCUSSION / Introduction --- p.87 / The first stage --- p.87 / The second stage --- p.95 / The third stage --- p.104 / Summary --- p.108 / Chapter CHAPTER6 --- IMPLICATIONS FOR NURSING PRACTICE --- p.111 / LIMITATIONS OF THE STUDY --- p.115 / RECOMMENDATIONS FOR FURTHER STUDY --- p.117 / CONCLUSIONS --- p.118 / REFERENCES --- p.121
64

'n Verkenning van kognitiewe beheerterapie by 'n adolessent met Downsindroom

Van Jaarsveld, Jana. January 2005 (has links)
Thesis (M.Ed.(Opvoedkundige Sielkunde))-Universiteit van Pretoria, 2005. / Abstract in English and Afrikaans. Includes bibliographical references.
65

Violence: heightened brain attentional network response is selectively muted in Down syndrome

Anderson, Jeffrey S., Treiman, Scott M., Ferguson, Michael A., Nielsen, Jared A., Edgin, Jamie O., Dai, Li, Gerig, Guido, Korenberg, Julie R. January 2015 (has links)
BACKGROUND: The ability to recognize and respond appropriately to threat is critical to survival, and the neural substrates subserving attention to threat may be probed using depictions of media violence. Whether neural responses to potential threat differ in Down syndrome is not known. METHODS: We performed functional MRI scans of 15 adolescent and adult Down syndrome and 14 typically developing individuals, group matched by age and gender, during 50 min of passive cartoon viewing. Brain activation to auditory and visual features, violence, and presence of the protagonist and antagonist were compared across cartoon segments. fMRI signal from the brain's dorsal attention network was compared to thematic and violent events within the cartoons between Down syndrome and control samples. RESULTS: We found that in typical development, the brain's dorsal attention network was most active during violent scenes in the cartoons and that this was significantly and specifically reduced in Down syndrome. When the antagonist was on screen, there was significantly less activation in the left medial temporal lobe of individuals with Down syndrome. As scenes represented greater relative threat, the disparity between attentional brain activation in Down syndrome and control individuals increased. There was a reduction in the temporal autocorrelation of the dorsal attention network, consistent with a shortened attention span in Down syndrome. Individuals with Down syndrome exhibited significantly reduced activation in primary sensory cortices, and such perceptual impairments may constrain their ability to respond to more complex social cues such as violence. CONCLUSIONS: These findings may indicate a relative deficit in emotive perception of violence in Down syndrome, possibly mediated by impaired sensory perception and hypoactivation of medial temporal structures in response to threats, with relative preservation of activity in pro-social brain regions. These findings indicate that specific genetic differences associated with Down syndrome can modulate the brain's response to violence and other complex emotive ideas.
66

Creating a new set of somatic cell hybrids to isolate human chromosome 21 expressed sequences

Yulug, Isik January 1996 (has links)
No description available.
67

Down Syndrome and Self-esteem: the Media's Portrayal of Self-esteem in Characters Who Have Down Syndrome

Gee, Courtney 12 1900 (has links)
Representations of people with a developmental disability are virtually not covered in the media. Although there is little coverage of people with developmental disabilities in the media, there are a few entertainment television characters who have Down syndrome and are represented in the media. This study will take a look at the history of how people with disabilities were represented in the media and examine how two television characters with Down syndrome were portrayed on the shows by examining their self-esteem. This study seeks to focus on portrayal of people with Down Syndrome because the physical features that people with Down Syndrome possess are easy to identify. Specifically, the study examines the portrayal of self-esteem in two television characters, Corky Thatcher (Life Goes On) and Becky Faye Jackson (Glee). The researcher will also examine how the portrayal of self-esteem in the two characters is similar or different in people who have Down Syndrome. In the study the researcher found that the representation of the character Corky was different from the character Becky. But both characters tackled issues that affected the Down Syndrome community and it affected their self-esteem. Corky and Becky were different from the interviewees in the way they realized their competencies. Although the interviewees who have Down Syndrome and the television characters used self-evaluation differently to evaluate one's own self-esteem, they all seem to exhibit a positive level of self-esteem.
68

Investigating clustering in trisomy 18 and trisomy 13

Cook, James Phillip January 2014 (has links)
Trisomies 18 and 13 are rare genetic conditions (occurring around 1 in 6,000 and 10,000 newborns respectively) which are caused by an extra copy of either chromosome 18 or 13, similar to trisomy 21 (Down syndrome). The only known risk factor for these syndromes is maternal age, however previous cluster analyses have linked trisomy risk to a number of alternate factors, including radiation exposure and infection. Cases of trisomies 18 and 13 from the National Down Syndrome Cytogenetic Register (NDSCR) were scanned for temporal and spatial clusters throughout England and Wales between 2004 and 2010. No temporal clusters were detected, however there were multiple significant spatial clusters detected for both trisomies in London. These clusters were likely caused by advanced maternal age in the region, and it is also possible that regional differences in gestational age at the time of prenatal screening could have contributed to these clusters. In order to account for maternal age and gestational age at diagnosis, a novel method was developed in R to directly weight cases based on these factors. Applying weights to cases directly allowed both factors to be simultaneously accounted for by multiplying weights together. This method was evaluated using synthetic data and compared with an alternate method in the widely used program SaTScan. Both programs returned similar results when the weighting method was mild, but when extreme weights were applied at random significant clusters were observed in SaTScan but not in R. The NDSCR data was weighted and then rescanned for spatial clusters in both programs. No evidence of clustering was detected using the novel method, while SaTScan returned multiple highly significant clusters. These findings, combined with those obtained using the synthetic data, indicate that the novel method produces more reliable results than SaTScan when extreme adjustment is applied.
69

Investigating the effects of chromosome 21 genes on pathological angiogenesis

Baker, Marianne January 2012 (has links)
Patients with trisomy of chromosome 21, known as Down’s syndrome (DS), have a lower incidence of solid tumours than unaffected age-matched individuals. However, the cellular and molecular basis for this observation is not well understood. We hypothesised that a direct link between Down’s syndrome and angiogenesis exists, whereby the overexpression of human chromosome 21 (Hsa21) genes causes the repression of angiogenesis (gene dosage effects) resulting in the inhibition of solid tumour growth. In this project we investigated the angiogenic phenotype of an animal model of Down’s syndrome, the Tc1 mouse, which contains a large freely segregating fragment of Hsa21 containing over 200 human genes. We found that the growth of both B16F0 melanoma and Lewis Lung Carcinoma cells was impaired in Tc1 mice. Tumour vascularity also was reduced. This is supportive of the epidemiological data from the human DS population and supports the hypothesis that Hsa21 contains anti-angiogenic genes. Candidate genes were selected due to their endothelial specificity or likelihood to function in angiogenesis based on functional data or similarity to other proteins. Ex vivo RNAi assays were used to examine their roles in angiogenesis. We have found that reducing the expression of human Adamts1, Erg, Jamb or Pttg1ip in Tc1 tissue can restore its angiogenic potential, suggesting that the dosage of these genes (i.e. 3 copies instead of 2) can inhibit angiogenesis. Following from this study we also examined the role of selected adhesion related genes found on chromosome 21 in angiogenesis. Cldn14 encodes the tight junction molecule Claudin14 but its role in angiogenesis was unknown. We found that partial, but not complete, depletion of Cldn14 can increase the proportion of non-lumenated tumour blood vessels; decrease supporting cell association with tumour vessels; and increase endothelial cell proliferation in vivo, ex vivo and in vitro. Taken together this series of experiments has identified novel regulators of angiogenesis and has demonstrated the gene dosage effects of a subset of Hsa21 genes on angiogenic processes.
70

Investigation into the structure and function of a novel cellular structure

Abrehart, Robert W. January 2016 (has links)
Down's syndrome (DS) is a congenital disorder caused by trisomy of chromosome 21, giving rise to symptoms including intellectual disability, poor muscle tone and characteristic facial features. Located on chromosome 21 is a gene encoding ubiquitin specific protease 25 (USP25), a member of the deubiquitinating family of enzymes. Studies of partial trisomies have revealed that although the USP25 gene is situated outside the critical region of chromosome 21 required to be triplicated to induce full DS symptoms, it is in a region linked to mild mental retardation and muscle hypotonia. Previous data has shown that, when overexpressed, USP25 forms novel rod shaped structures approximately 3-5 μm in length and 0.3-0.6 μm wide, and with a copy number, on average, of no more than 1-2 per cell. These structures do not associate with any known cellular organelle or with any component of the cytoskeleton. In this work, endogenous USP25 rods were detected in cultures of primary human foetal astrocytes, and a comparison of healthy and DS human primary foetal astrocytes revealed that in the DS culture a higher percentage of astrocytes contain rods. The domains of USP25 required for rod formation were identified using a series of GFP-tagged deletion constructs. USP25 rods could be purified from HEK293 cells using subcellular fractionation techniques and were assayed for deubiquitinating activity; however, none was detected suggesting that rods may be catalytically inactive. Interacting partners of USP25 were identified using mass spectrometry, but none were found to localise in rods. Additionally, a USP25 null human embryonic stem cell line was generated in order to interrogate the function of USP25 in astrocytes, and was found to be deficient in maintaining the integrity of an epithelial cell layer in an in vitro model of the blood brain barrier.

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