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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Neuronal connectivity in the larval visual system of Drosophila melanogaster : cellular and molecular analysis /

Mukhopadhyay, Mahua. January 1999 (has links)
Thesis (Ph.D.) -- McMaster University, 1999. / Includes bibliographical references. Also available via World Wide Web.

Characterization of chromatin architecture and the mechanism of dosage compensation in Drosophila melanogaster

Bishop, Eric Paul January 2012 (has links)
Thesis (Ph.D.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / Chromatin, the DNA/protein complex that makes up the major part of eukaryotic chromosomes, plays an important role in regulating many biological processes. Distinct patterns of histone occupancy correlate with different levels of transcriptional activity and with many functional elements. Modern high-throughput sequencing technology combined with chromatin immunoprecipitation (ChIP) has made it possible to profile histone modification patterns on a genome-wide scale for large mammalian genomes. In this thesis, I perform the first comprehensive comparison of histone modifications and nucleosome occupancy between D. melanogaster and H. sapiens. A systematic comparison among multiple organisms is challenging due to issues in integrating datasets derived from multiple platforms and technologies, but I show that proper normalization enables this comparison. My analysis reveals key differences in enrichment patterns of histone modifications, which are driven by differences in nucleosome occupancy. One biological system in which chromatin architecture plays a major role is Drosophila male dosage compensation, the process by which male X-linked genes are up-regulated to compensate for the lack of a second copy. Dosage compensation is regulated primarily by the Male-Specific Lethal (MSL) protein complex. However, the mechanisms by which MSL up-regulates X-linked genes and by which it specifically targets the X chromosome remain poorly understood. I performed analysis of Global Run-on Sequencing (GRO-seq) to determine the specific effect of MSL on the level of nascent transcripts in male Drosophila cells. My analysis indicates that MSL activity results in increased RNA polymerase density within the bodies of active X-linked genes, suggesting that regulation occurs at the level of transcriptional elongation. To further investigate the targeting mechanism of MSL, I examined expression and binding data for CLAMP (Coupling Lethal Adapter for MSL Proteins) a previously uncharacterized protein identified in a recent screen as a regulator of MSL. This analysis reveals that CLAMP exhibits a synergistic relationship with MSL and promotes X-chromosome specificity. Taken together, my results provide novel insights into the nature of the Drosophila chromatin landscape and the regulatory mechanism of dosage compensation. / 2031-01-01

Motor neuron development in the Drosophila embryonic central nervous system /

Layden, Michael J, January 2006 (has links)
Thesis (Ph. D.)--University of Oregon, 2006. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 101-115). Also available for download via the World Wide Web; free to University of Oregon users.

Spatial and temporal coordination of oskar mRNA localization and translation during drosophila oogenesis

Koppetsch, Birgit S. January 2003 (has links)
Thesis (M.S.)--Worcester Polytechnic Institute. / Keywords: Drosophila; axis specification; oogenesis; oskar mRNA. Includes bibliographical references (p. 73-81).

Functional analysis of lipid phosphate phosphohydrolases (LPP) in Drosophila melanogaster phototransduction cascade

Garcia-Murillas, Isaac January 2007 (has links)
No description available.

The nuclear organisation of Drosophila melanogaster primary spermatocytes

Redhouse, Juliet Lauren January 2009 (has links)
No description available.

Characterisation of starvin' : a novel Drosophila melanogaster gene /

Coulson, Michelle R. January 1999 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Dept. of Genetics, 2000. / Bibliography: p. 133-141.

The analysis of genes expressed in the sperm storage organs of Drosophila melanogaster patterns of evolution and expression /

Prokupek-Pickett, Adrianne Marie. January 1900 (has links)
Thesis (Ph.D.)--University of Nebraska-Lincoln, 2008. / Title from title screen (site viewed Aug. 14, 2008). PDF text: xi, 178 p. : ill. (some col.) ; 664 K. UMI publication number: AAT 3297753. Includes bibliographical references. Also available in microfilm and microfiche formats.

Effect on heartbeat of drosophila melanogaster of mutations in the calcium channel encoding cacophony gene and its interaction with the rna helicase mutant maleless napts /

McGowan, Vanessa, January 2003 (has links) (PDF)
Thesis (M.S.) in Zoology--University of Maine, 2003. / Includes vita. Includes bibliographical references (leaves 161-171).

Studies on the responder locus of the segregation distorter system of drosophila melanogaster

Houtchens, Kathleen A. January 2000 (has links)
Thesis (Ph. D.)--University of Hawaii at Manoa, 2000. / Includes bibliographical references (leaves 125-132). Also available on microfiche.

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