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Effects of crude leaf extracts of Ficus thonningii on growth, gastrointestinal morphometrry and clinical biochemistry of suckling Sprague Dawley ratsDangarembizi, Rachael 17 February 2014 (has links)
Ficus thonningii is a nutraceutical that is extensively used in ethnomedicine. Nursing mothers
use F. thonningii leaves as nutritional and medicinal supplements and are at risk of exposing
their infants to its constituent phytochemicals. The exposure of the sensitive neonatal
gastrointestinal tract (GIT) to these phytochemicals can result in irreversible changes in
growth and development. The objectives of this study were to determine the effects of crude
F. thonningii extracts on; growth, morphology and morphometry of the abdominal viscera
and clinical biochemistry of neonatal rats.
Forty, suckling Sprague Dawley rats of either sex were randomly divided into 5 groups. Each
group was orally gavaged once daily with either low (50 mg/kg b.w) or high (500 mg/kg b.w)
doses of aqueous or methanolic extracts of F. thonningii, for 7 days. The control rats received
distilled water. The pups were euthanased and tissues were collected and weighed. Samples
of the liver, caecum and proximal small intestine were preserved and processed for histology.
Plasma biochemical parameters were analysed colorimetrically. Data was presented as means
+ SD.
F. thonningii extracts exhibited trophic effects on the stomach and ceacal mucosa of rats but
had no significant growth-promoting effects on the small intestine and visceral organs.
Histological analysis of the intestine, liver and caeca revealed no mucosal damage. Clinical
chemistry parameters were not abnormally altered. There was a significant decrease (p<0.05,
ANOVA) in the plasma concentrations of basal (non-fasting) glucose in the pups on the high
methanolic extracts. However, the triglyceride and cholesterol levels were unaltered by the
treatments.
The findings suggest that F. thonningii extracts exhibit trophic effects on the mucosal layers
of the stomach and caecum. F. thonningii extracts also possess glucose-lowering activity. At
low doses, F. thonningii extracts can be safely used without the risk of any disruption in the
structural integrity of the neonatal rat GIT and function of the liver and kidneys.
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Development of monoclonal antibodies in the detection of nandrolone metabolites.January 1992 (has links)
Chun Sing Chu. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1992. / Includes bibliographical references (leaves 139-149). / Acknowledgements --- p.i / Abstract --- p.ii / Abbreviations --- p.vi / Chapter Chapter 1 --- General Introduction --- p.1 / Chapter Chapter 2 --- "Development of Polyclonal Antibodies against 5α-Estrane-3β,17α-diol" / Chapter 2.1 --- Introduction --- p.39 / Chapter 2.2 --- Materials and Methods --- p.45 / Chapter 2.3 --- Results --- p.55 / Chapter 2.4 --- Discussion --- p.64 / Chapter Chapter 3 --- "Development of Monoclonal Antibodies against 5α-Estrane-3β,17α-diol" / Chapter 3.1 --- Introduction --- p.69 / Chapter 3.2 --- Materials and Methods --- p.86 / Chapter 3.3 --- Results --- p.107 / Chapter 3.4 --- Discussion --- p.126 / Chapter Chapter 4 --- General Conclusion --- p.134 / References --- p.139
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Use of microdialysis as a tool to determine tissue distribution of lipophilic and high molecular weight compoundsSchuck, Virna Josiane Aurelio. January 2004 (has links)
Thesis (Ph.D.)--University of Florida, 2004. / Typescript. Title from title page of source document. Document formatted into pages; contains 139 pages. Includes Vita. Includes bibliographical references.
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Bioequivalence study of pioglitazone tablets in Thai healthy volunteers /Khin Myo Oo, Korbtham Sathirakul, January 2007 (has links) (PDF)
Thesis (M.Sc. (Pharmaceutics))--Mahidol University, 2007. / LICL has E-Thesis 0025 ; please contact computer services.
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The applications of image processing in biology and relevant data analysis.January 2007 (has links)
Wang, Zexi. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2007. / Includes bibliographical references (leaves 63-64). / Abstract --- p.i / Acknowledgement --- p.iii / Chapter 0 --- Introduction --- p.1 / Chapter 1 --- The Design of the Experiments --- p.4 / Chapter 1.1 --- Flies and the Devices --- p.5 / Chapter 1.2 --- Parameter Settings and Interested Information --- p.8 / Chapter 2 --- Video Processing --- p.11 / Chapter 2.1 --- "Videos, Computer Vision and Image Processing" --- p.11 / Chapter 2.2 --- Details in Video Processing --- p.14 / Chapter 3 --- Data Analysis --- p.20 / Chapter 3.1 --- Background --- p.20 / Chapter 3.2 --- Outline of Data Analysis in Our Project --- p.22 / Chapter 4 --- Effect of the Medicine --- p.25 / Chapter 4.1 --- Hypothesis Testing --- p.26 / Chapter 4.2 --- Two-sample t Test --- p.28 / Chapter 5 --- Significance of the Two Factors --- p.32 / Chapter 5.1 --- Background of ANOVA --- p.33 / Chapter 5.2 --- The Model of ANOVA --- p.35 / Chapter 5.3 --- Two-way ANOVA in Our Data Analysis --- p.42 / Chapter 6 --- Regression Model --- p.45 / Chapter 6.1 --- Background of Regression Analysis --- p.47 / Chapter 6.2 --- Polynomial Regression Models --- p.52 / Chapter 6.2.1 --- Background --- p.52 / Chapter 6.2.2 --- R2 and adjusted R2 --- p.53 / Chapter 6.3 --- Model Verification --- p.58 / Chapter 6.4 --- A Simpler Model As the Other Choice --- p.59 / Chapter 6.5 --- Conclusions --- p.60 / Chapter 7 --- Further Studies --- p.61 / Bibliography --- p.62
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