Drug-manufacture field can be broadly defined as one of biology industries, its strength or weakness is certainly close to people¡¦s daily lives. Even through the market size is slightly related to global markget in drug manufacturing, its development is closely related to domestically whole biology industry. Hence, the drug manufacture field in Taiwan was targeted in this thesis, and subjected to customer satisfactory as the reference for further upgrading and promoting. Besides, I have been inheriting my family company for servral years, so hope to understand the factors which affect on customer satisfactory where are beneficial for future operation through this research. The primary data were collected with questionnaires which were delivered to the customers of H Company. They are divided into 3 areas (northern, middle & southern of Taiwan), and five drugstores were chosen in each area. 150 copies were scheduled to be delivered, however, 251 effective copies were returned back (return rate is 87.75%). After independent T test, Chi-test and ANOVA, we conclude as followed, First, in the aspects of the results of factors among top 5 products, only both resident area and educational background can influence on comsumption of different products. Different products can be delivered based on different area to rise up the revenue amounts. Second, of aspects of product repurchasement, gender, resident area and educational background, the three factors will influence on times of product purchasement. Third, likewise, only both resident area and educational background can influence on different channels.Relatively speaking, most of customers are introduced by broadcasting in Middle-southern of Taiwan, and the percentages of poor-educated people are higher among them. Forth, of aspects of the affective factors of customer satisfactory, only resident area resulted in diversifications in customer satisfactory. To be further analyzed, north and middle customers do not differ, but the south of customer satisfactory is significantly higher than the former. Those cutomer satisfactories are independent among different products and channels after ANOVA analysis.

At Amgen, the Automated Vision Inspection (AVI) systems capture the movement of unwanted particles in Amgen's drug product containers. For quality inspection, the AVI system must detect these undesired particles using a high speed spin-stop agitation process. To better understand the fluid movements to swirl the particles away from the walls, Computational Fluid Dynamics (CFD) is used to analyze the nature of the two phase flow of air and a liquid solution. Several 2-D and 3-D models were developed using Fluent to create simulations of Amgen's drug product containers for a 1 mL syringe, 2.25 mL syringe, and a 5 mL cartridge. Fluid motion and potential bubble formations were studied within the liquid/gas domain inside the container by varying parameters such as viscosity, angular velocity, and surface tension. Experiments were conducted using Amgen's own equipment to capture the images of the spin-stop process and validate the models created in Fluent. Observations were made to see the effects of bubble formation or splashing during spin-down to rest. The numerical and experimental results showed favorable comparison when measuring the meniscus height or the surface profile between the air and liquid. Also, at high angular velocity and dynamic viscosity, the container experiences instabilities and bubble formations. These studies indicate that CFD can be used as an useful and important tool to study fluid movement during agitation and observe any undesirable results for quality inspection.