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Fluoroquinolone resistance mechanisms in ten clinical isolates of fluoroquinolone-resistant Streptococcus pneumoniae in Hong KongCheng, Kim-wai., 鄭劍偉. January 2000 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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Mechanisms underlying the preferential killing of human multidrug resistant KB carcinoma cells by 2-deoxy-d-glucoseBell, Susan Elizabeth January 1998 (has links)
No description available.
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The evolution of the matrix genes of human influenza A and relationships to functional propertiesElliot, Alexander James January 2001 (has links)
No description available.
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Some aspects of the quality of certain pharmaceutical products from Nigeria and ThailandShakoor, Omar January 1998 (has links)
No description available.
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Phosphinic acids as inhibitors of D-Ala-D-Ala adding enzymeMiller, David James January 1997 (has links)
No description available.
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The evaluation of novel inactivators of O'6-methylguanine-DNA methyltransferaseArris, Christine Elizabeth January 1998 (has links)
No description available.
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The role of glutathione and mu class glutathione s-transferases in childhood acute leukaemiaKearns, Pamela Renate January 2000 (has links)
No description available.
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Defective mismatch repair and cisplatin resistance in ovarian cancer cellsAnthoney, David Alan January 1997 (has links)
No description available.
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Molecular interactions of P-glycoproteinTaylor, Jenny Carmeron January 1997 (has links)
No description available.
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Is there an association between trimethoprim-sulfamethoxazole use as prophylaxis and multi-drug resistant non-typhoidal salmonella? A secondary data analysis of antibiotic co-resistance surveillance data in South Africa - 2003-2005Nanoo, Ananta 10 March 2011 (has links)
MSc (Med), Epidemiology and Biostatistics, Faculty of Health Sciences, University of the Witwatersrand / Introduction
Given the increasing prevalence of non-typhoidal salmonella in humans, especially as an
opportunistic illness associated with HIV, enhanced surveillance for non-typhoidal salmonella
(NTS), including screening for antibiotic resistance, is conducted annually in South Africa. We
aimed to determine whether there is an association between trimethoprim-sulfamethoxazole
(TMP-SMX) prophylaxis and multi-drug resistant NTS infection, to establish whether various
factors modify the relationship between TMP-SMX resistance and invasive NTS infection, to
examine whether these associations vary by province, and to quantify the resistance rates of NTS
to a range of antibiotics.
Methods
This study was a secondary analysis of enhanced surveillance data on NTS collected between
2003 and 2005. We used descriptive methods to assess the prevalence of NTS by year, province
and serotype, and to determine the prevalence of four MDR patterns. Univariate and multivariate
regression models were used to investigate the relationships between TMP-SMX prophylaxis
and MDR NTS. Univariate logistic regression was used to assess the relationship between
invasive NTS and TMP-SMX resistance.
Results
TMP-SMX prophylaxis is associated with the ACKSSuT pattern (OR 1.91, 95% CI 1.14 – 3.19,
p=0.0080) and the AKSSuT MDR pattern (OR 2.00, 95% CI 1.26 – 3.15, p=0.0015). Being on
TMP-SMX prophylaxis is associated with an increased odds of having at least one of the four
MDR patterns investigated (OR 1.43, 95% CI 1.00 – 2.04, p=0.0388). We also found high rates
of resistance to all antibiotics tested except for ciprofloxacin and imipenem. The highest
resistance rate was observed for sulfamethoxazole (>75.85%). S. enterica Isangi isolates showed
the highest levels of resistance, with 94.43% having at least one MDR pattern. Other factors
significantly associated with MDR NTS were ESBL production, prior treatment with antibiotics,
HIV status and resistance to TMP-SMX.
Discussion and conclusions
Isolates from patients on TMP-SMX prophylaxis were associated with an increased odds of
having the ACKSSuT and AKSSuT MDR patterns, not taking into account other explanatory
factors. These associations did not remain significant when possible confounders were taken into
account. Despite the threat of increased multi-drug resistance, TMP-SMX prophylaxis remains
important in certain clinical settings.
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