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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Stability, packaging, storage, and sterilization of a medicated dry foam

Gostanian, Armen 01 January 1975 (has links)
The basic unmedicated formula consists of dextran, sorbitol, Miranol 2 MCA Modified, and water. The major advantages of the film are 1) fast release rates, 2) ease of application to denuded skin without aggravation, and 3) lack of necessity for removal, hence no aggravation. However, it is extremely sensitive to moisture and elevated temperatures which is a major disadvantage. Excessive humidity will solubilize the film or make it too tacky to handle while very low humidity causes the film to lose its flexibility. Also, elevated temperatures remove moisture from the film and cause it to lose flexibility much as with low humidities. This study was designed to evaluate further this new dosage form with respect to: (1) Modification of formula to minimize moisture sensitivity.; (2) Determination of a suitable packaging material.; (3) Determination of proper storage conditions.; (4) Determination of shelf-life of silver sulfadiazine and nitrofurazone dry foams.; (5) Determination of a suitable sterilization method(s).

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