Spelling suggestions: "subject:"drugs."" "subject:"rugs.""
411 |
Pharmaceuticals in the environment : the effects of clofibric acid on fishRunnalls, Tamsin January 2005 (has links)
Pharmaceuticals in the aquatic environment is an emerging issue and the risks they pose are mostly unknown. They are used in large amounts throughout the world and can enter the environment, as the active metabolite or unmetabolised, through excretion by people and improper disposal. As these drugs are designed to have specific biological effects in a specific organism (as well as sometimes having other non-specific side effects), their potential to cause effects within the environment is great. Clofibric acid (the major metabolite of the lipid lowering drug, Clofibrate) is non-biodegradable, highly motile, very persistent and frequently detected at μg/I levels in the environment. I studied possible effects of clofibric acid in fish, using different experimental approaches and endpoints. The studies involve two different species, and for one of these species, fish at different stages of development. The chapters within this thesis have presented the first evidence (albeit preliminary) of clofibric acid having effects on both adult and embryo fish. When fathead minnow embryos were exposed to clofibric acid, the effects seen included changes in the eggshell, time to hatch, hatchability, mortality and viability. Adult fathead minnow were similarly exposed and significant effects on specific parameters were also observed. These included effects on lipid metabolism, steroidogenesis and spermatogenesis - thought to be via cholesterol transport - as well as significant effects on the expression of several genes involved in lipid metabolism and detoxification. Exposure of juvenile (sexually undifferentiated) bream also found significant differences in some endpoints. Other results suggested, less pronounced effects of clofibric acid on some other parameters. The results from this research show that there are effects of clofibric acid in pathways which were not only unexpected in fish (for example, steroidogenesis, spermatogenesis and gene expression), but also at concentrations below those previously shown to have any biological effects on fish. These effects indicate that clofibric acid may potentially have an impact on fish fecundity, and even more worryingly, on human health for those people prescribed it.
|
412 |
Physical and chemical properties of acrylic polymers influencing physical agingKucera, Shawn Anthony, January 1900 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.
|
413 |
Die Zwangslizenz im südafrikanischen und deutschen Patentrecht : ein Rechtsvergleich unter besonderer Berücksichtigung der Arzneimittelerfindungen /Harnisch, Sandy. January 2006 (has links) (PDF)
Univ., Diss.--Göttingen, 2005. / Literaturverz. S. 323 - 341.
|
414 |
Patterns of drug prescription and their effect upon cost of drugs in a community hospital submitted ... in partial fulfillment ... Master of Hospital Administration /Warden, Gail L. January 1962 (has links)
Thesis (M.H.A.)--University of Michigan, 1962.
|
415 |
Preformulation and formulation of steroids and assessment of an electronically modulated intravaginal device for induced calving or oestrous synchronization of cattleIsmail, Ali Abdi. January 2006 (has links)
Thesis (Ph.D. Biotechnology)--University of Waikato, 2006. / Title from PDF cover (viewed April 8, 2008) Includes bibliographical references (p. 222-234)
|
416 |
Biodegradation of pharmaceuticals by microorganismsGauthier, Hervé, January 1900 (has links)
Thesis (M.Eng.). / Written for the Dept. of Chemical Engineering. Title from title page of PDF (viewed 2009/06/17). Includes bibliographical references.
|
417 |
Patterns of drug prescription and their effect upon cost of drugs in a community hospital submitted ... in partial fulfillment ... Master of Hospital Administration /Warden, Gail L. January 1962 (has links)
Thesis (M.H.A.)--University of Michigan, 1962.
|
418 |
Comparison of various chiral stationary phases for the chromatographic separation of chiral pharmaceuticals /Layton, Sherry E. January 2005 (has links) (PDF)
Thesis (M.S.)--University of North Carolina at Wilmington, 2005. / Includes bibliographical references (leaves: [85]-87)
|
419 |
Some aspects of drug distribution under tax supported programsBachynsky, John A. January 1967 (has links)
Thesis (Ph. D.)--University of Wisconsin, 1967. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
|
420 |
Pharmacokinetics, pharmacodynamics and metabolism of GTI-2040, a phosphorothioate oligonucleotide targeting R2 subunit of ribonucleotide reductaseWei, Xiaohui, January 2006 (has links)
Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 290-308).
|
Page generated in 0.0768 seconds