Thesis (M.S.)--Tennessee Technological University, 2008. / Title from title page screen (viewed on Sept. 28, 2009). Bibliography: leaves 79-80.

Thesis (M.S.)--Tennessee Technological University, 2009. / Title from title page screen (viewed on June 29, 2010). Bibliography: leaves 73-75.

Thirty six consecutive patients with primary sclerosing cholangitis (PSC), 20 males median age 42 years, were studied in order to define prognostic variables and determine the influence of surgery on outcome. Presentation was usually with insidious cholestasis or recurrent cholangitis. Twenty six patients (72 per cent) had associated inflammatory bowel disease (ulcerative colitis 20, Crohn's disease 2, unclassified 4). Thirty two patients were followed prospectively for up to nine years. Twenty three remained either stable or had slowly progressive disease. Of the remaining nine patients, seven died (five from end-stage liver failure and two from cholangiocarcinoma) and two patients underwent liver transplantation. Actuarial survival at five years was 52 per cent. A raised serum bilirubin concentration was the only variable at presentation that independently predicted a poor outcome. Cholangiograms were available for detailed assessment in thirty PSC patients. Neither the extent of biliary involvement nor the presence of surgical correctable ("dominant") strictures in the extrahepatic ductal system were of prognostic importance. Six patients who developed obstructive jaundice associated with advanced liver disease underwent surgical drainage operations for dominant biliary strictures, but this did not seem to prevent progression of the disease. Two patients who progressed to end-stage liver disease went on to liver transplantation and were alive with functioning grafts at seven and fourteen months respectively. Nine patients with asymptomatic PSC were followed prospectively for up to twelve years. None of these patients developed overt liver disease but serum bilirubin levels became mildly elevated in two patients. It is concluded that symptomatic PSC is a progressive disease with a poor prognosis. Patients with advanced liver disease due to PSC should be considered directly for liver transplantation. In contrast, asymptomatic PSC patients may remain symptom-free for many years.

<p> Large ducts are used to carry air and flue gases to and from industrial processes and can be subjected to a variety of loading conditions. To maintain the structural integrity of the ducts, stiffeners are attached to the casing to form a more rigid frame. Stiffeners protect the duct casing by reducing the unsupported span of the plate, hold the original shape of the duct, and are used for overall duct support or restraint. </p> <p> Current methods used to size stiffeners on industrial ducts are derived from standard equations used for beam design in buildings with some accommodation for the composite section formed by the beam and casing plate. These methods are shown to be significantly conservative with a safety factor in the order of four to five. This large conservatism in the design results in higher capital costs and construction costs. </p> <p> To determine the actual capacity of a stiffener beam relative to the design limit, an experimental program was developed. A box was fabricated with a removable top plate that incorporated one of two different beam stiffeners. The box was subjected to a vacuum pressure and the response of the beams was monitored until their final collapse. </p> <p> A finite element model was developed to simulate the experiment. Reasonable agreement between the finite element model and the experimental data was found. Subsequently, a parametric study was conducted using the developed finite element model. </p> <p> An alternative analytical design method was presented that took into account composite action. This includes the location of the neutral axis, the location of the load along the height of the beam, and the contribution of the web to the support of the outstanding compression flange. Each of these factors provides an increase in bending capacity for the stiffener. </p> <p> The proposed alternative method continues to provide conservative results relative to the point of failure determined by both the experimental program and the finite element analysis. However, the results are substantially less conservative than what is provided through the current design methods. </p> / Thesis / Master of Applied Science (MASc)

No description available.

The accurate prediction of pipe contraction pressure loss is important in the design of pipe system such as heat exchangers, particularly when close control of the flow distribution in a network of pipes is required. The prediction of contraction pressure loss depends heavily on experimental data. Large discrepancies in these predictions are evident in the literature. Experimental results giving pres!? re loss coef fici ents for a range of Reyno 1 ds numbers of 4x 10 -2x 10 and area ratios of 0.135 - 0.692 are presented and compared with predictions from a method developed that allows for velocity profile variation through the contraction. The results show a Reynolds number dependence and good agreement between predicted and measured values. It is also important to be able to predict the variation of pressure loss coefficient with variations in the small-bore inlet geometry, referred to as the inlet sharpness. There are no know experimental data for the effects of inlet sharpness on the pipe contraction loss coefficient, but there are data for intakes set flush in a plane wall which are used as approximations. Experimental data showing the variation of pressure loss coefficient with inlet sharpness up to 13.4% are presented and compared with approximate data. The comparison shows significant differences. A three beam laser doppler anemmeter has been used to measure the detailed flow field for an area ratio of 0.332 and a Reynolds number of 153.8 x 10. The mean velocity, turbulent intensity and Reynolds stress distributions are presented for twenty-two axial stations between four large-bore diameters upstream to fourteen small-bore diameters downstream of the contraction. These experimental measurements are compared with computer predictions using the FLUENT code with the k-e- turbulence model. The general trends in the flow are predicted, however there are significant differences in the detailed flow field which are highlighted.

Thesis (M. Med. Sc.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves 73-81).

Thesis (M.Med.Sc.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves 73-81). Also available in print.

Thesis (M.S.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains vii, 59 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 48-49).

Thesis (M.S.)--University of Wisconsin, 1960. / Typescript. "The experimental work in this study was performed in the laboratory at Marquete University, College of Engineering."--P. [ii]. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.