Proposed reduction in maximum allowable cadmium (Cd) level in wheat grain from 0.2 to 0.15 ppm by European Union (EU) could affect Arizona wheat growers substantially. The possible breeding programs and management practices needs to be developed to keep the industry competitive for this major market. In this study, we used two durum wheat cultivars (Ocotillo representing higher Cd genotypes and Havasu representing lower Cd genotypes) to study the potential of Zn fertilizer (as ZnSO₄ and ground tire rubber) to reduce Cd uptake in durum wheat at Yuma Ag Center. While cadmium level in the two varieties were different significantly, applying ZnSO₄ or ground rubber did not affect grain cadmium level, grain yield, or protein content significantly.