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Rausvažiedės ežiuolės Echinacea purpurea (L.) Moench antiandrogeninių savybių eksperimentiniai tyrimai / Experimental studies of antiandrogenic properties of Echinacea purpurea (L.)MoenchSkaudickas, Darius 09 December 2005 (has links)
1. INTRODUCTION
1.1. Work actuality
In recent years the number of males with urination disorders mostly induced by prostate pathology has significantly increased [Gas et al., 1998; Khan, Khan et al., 2005; Amaral, Coeli et al., 2004]. Benign prostate hyperplasia (BPH) affects males at a much younger age making them complain of urination disorders of different types and intensity. It is quite a common pathology among males (which is) conditioned by life style and nutrition [Saga & Sugimura, 2004; Shabbir & Mumtaz, 2004; Cambell, 2005].
Clinical symptoms of BPH are not restricted only to urination complaints. With an increase of age of males, the balance of androgens and estrogens undergoes changes in the male organism, affecting the power of libido. According to C.M.Porth, 2005, two theories related to senility have been created, trying to explain biological processes occurring with age: The first theory is related to the so called genetically programmed changes. This theory affirms that changes brought on by aging, are genetically predetermined. Another theory is called the stochastic theory which says that all changes are of accidental nature, i.e. the body undergoes accidental changes. There is one more theory, the so-called neuroendocrinic theory of senility. This theory involves three basic factors of the process of aging: 1) facilitated degradation of hormones, 2) decreased synthesis and secretion of hormones, 3) diminished sensitivity of “target” receptors to... [to full text]
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