<p>This examination work is about implementation of Cisco Systems Network Admission Control (NAC) within a leading IT-company in region of Jönköping. NAC is a technique that is used for securing the internal network from the inside. NAC can verify that the client who connects to the network has the latest antivirus updates and latest operative system hotfixes. Clients who don’t meet the criteria can be placed in quarantine VLAN where they only have access to the update servers. There are also functions that handle VLAN assignment for users.</p><p>The assignment where to produce a solution for an implementation of NAC in the company’s computer network. The questions that where asked are the following, if and how could NAC be implemented in the company’s computer network.</p><p>An analysis where made of the company’s computer network, to see if the computer network meet the requirements for implementing NAC. The result of this analysis showed that there where a loss of functions needed for a working NAC solution. The computer network where rebuild from scratch to meet the new demands for NAC. After completion of the new computer network the NAC solution were taking shape. This was made in consultation with the company to get a clear picture of the needs. The result of the discussion lead to a so called “Out-of-band virtual gateway” solution. The solution builds on that the client is placed in an authentication VLAN when connecting to the computer network, after that an authentication process begins. During this process the client is checked to verify that the criteria’s are fulfilled, if so the client is moved to his access VLAN.</p><p>These solutions increase the internal security in the computer network and reduce the risks for virus spreading within the network.</p>

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The main objective for this degree project was to analyze the Endpoint Security Solutions developed by Cisco, Microsoft and a third minor company solution represented by InfoExpress. The different solutions proposed are Cisco Network Admission Control, Microsoft Network Access Protection and InfoExpress CyberGatekeeper. An explanation of each solution functioning is proposed as well as an analysis of the differences between those solutions. This thesis work also proposes a tutorial for the installation of Cisco Network Admission Control for an easier implementation. The research was done by reading articles on the internet and by experimenting the Cisco Network Admission Control solution. My background knowledge about Cisco routing and ACL was also used. Based on the actual analysis done in this thesis, a conclusion was drawn that all existing solutions are not yet ready for large-scale use in corporate networks. Moreover all solutions are proprietary and incompatible. The future possible standard for Endpoint solution might be driven by Cisco and Microsoft and a rude competition begins between those two giants.

Made available in DSpace on 2014-06-12T15:55:41Z (GMT). No. of bitstreams: 2 arquivo2277_1.pdf: 7944463 bytes, checksum: 71e44fc92615878dd62584a90aa46425 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2010 / Surgiu nos últimos anos a discussão sobre um framework de segurança que fosse capaz de suprir a necessidade de integração entre as diversas ferramentas de segurança: o NAC (Network Access Control). Este framework chega em um momento onde a computação converge para o emprego da computação ubíqua. Sendo assim, o objetivo deste trabalho é propor informações de contexto que contribuirão com novas formas de análises ao framework de segurança NAC. Utilizamos métricas que mostram os contextos alterados durante ataques a um dispositivo. Mostramos que é possível mapear estas alterações e com isso mudar as regras de acesso à rede do dispositivo baseados nestas mudanças de contextos

This examination work is about implementation of Cisco Systems Network Admission Control (NAC) within a leading IT-company in region of Jönköping. NAC is a technique that is used for securing the internal network from the inside. NAC can verify that the client who connects to the network has the latest antivirus updates and latest operative system hotfixes. Clients who don’t meet the criteria can be placed in quarantine VLAN where they only have access to the update servers. There are also functions that handle VLAN assignment for users. The assignment where to produce a solution for an implementation of NAC in the company’s computer network. The questions that where asked are the following, if and how could NAC be implemented in the company’s computer network. An analysis where made of the company’s computer network, to see if the computer network meet the requirements for implementing NAC. The result of this analysis showed that there where a loss of functions needed for a working NAC solution. The computer network where rebuild from scratch to meet the new demands for NAC. After completion of the new computer network the NAC solution were taking shape. This was made in consultation with the company to get a clear picture of the needs. The result of the discussion lead to a so called “Out-of-band virtual gateway” solution. The solution builds on that the client is placed in an authentication VLAN when connecting to the computer network, after that an authentication process begins. During this process the client is checked to verify that the criteria’s are fulfilled, if so the client is moved to his access VLAN. These solutions increase the internal security in the computer network and reduce the risks for virus spreading within the network.

Notre travail s’est focalisé sur l’utilisation du trastuzumab‐immunoPET afin d’étudier et deguider une approche nouvelle visant à surmonter la résistance au médicament trastuzumab,causée par la surexpression de MUC4 dans le cancer du sein.Pour ce faire, nous avons préparé et utilisé du 89Zr‐trastuzumab dans le but de suivresa capacité de liaison au récepteur HER2 ainsi que son accumulation dans des cellulescancéreuses mammaires. Ensuite, nous avons formulé l’hypothèse que des agentsmucolytiques, tels que la N‐Acétylcystéine (NAC), en démêlant les réseaux formés par lesmucines, permettent l’amélioration de la captation du radiotraceur in vitro et in vivo. Eneffet, l’addition du NAC a occasionné une accumulation significative de 89Zr‐trastuzumab,sans altération ni changement de l’affinité de liaison au récepteur. Ceci semble égalementproduire une meilleure sensibilité des imageries PET dans le modèle animal choisi.Dans une seconde étape, nous avons évalué, dans un modèle murin de cancer du seinrésistant au trastuzumab et surexprimant la MUC4, si cette captation accrue se traduit parun bénéfice thérapeutique en utilisant le NAC combiné au trastuzumab. Nous avons obtenuun effet inhibiteur qui réduit de moitié la croissance tumorale, comparable à celui observépour la tumeur mammaire sensible au trastuzumab (implantée dans le même animal).En conclusion, notre étude démontre l’efficacité de l’utilisation de traceurs PETsurtout à visée théranostique, comme c’est le cas du 89Zr‐trastuzumab, pour étudier etévaluer la résistance aux médicaments ciblés apparentés au radiotraceur lui‐même. Ellepropose l’utilisation du NAC pour améliorer l’accessibilité du récepteur pour le radiotraceurainsi que pour le médicament « froid » ouvrant, de ce fait, une perspective vers uneutilisation clinique chez un sous‐type de patientes atteintes d’un cancer du sein. / Doctorat en Sciences biomédicales et pharmaceutiques (Pharmacie) / info:eu-repo/semantics/nonPublished

Class of 2014 Abstract / Specific Aims: To determine the cost of treatment of oral and intravenous n-acetylcysteine (IV NAC) in acute acetaminophen (APAP) toxicity using the length of treatment and length of hospital stay. Methods: A retrospective chart review of Arizona Poison and Drug Information Center electronic records from 2009-2012 and January-June 2013 were evaluated. The following information was collected: age, sex, use oral or intravenous NAC, length of treatment, length of hospital stay (intensive care unit (ICU) and non-ICU) and use of antiemetic. The mean length of stay (MLOS) was calculated for each group as well as the cost of IV and oral NAC. These means were then compared using t-test for independent groups to test for significance. The average total cost of IV and oral NAC treatment was calculated by using monetary values from primary literature. A sensitivity analysis was performed to test the possible effects of an increase or decrease of the final costs by 5 to 10%. Main Results: Patients (≥18 yrs) being treated with IV or oral NAC for acute APAP toxicity (≤8 hours prior to ingestion) were included in this study. A total of 47 patients met the inclusion criteria. Length of hospital stay was shorter in patients receiving IV NAC (42.5% 24-24hr; 37.5% 48-72hr) compared to patients receiving oral NAC (28.6% 48-72hr, 71.4% >72hrs; p<0.001). Total cost of ICU/non-ICU stay in patients receiving IV NAC ($8,720/$3010) was less than patients receiving oral NAC ($12,321/$4703); however, cost of IV NAC-extended (37hrs) in ICU/non-ICU ($13,153/$5535) was greater than oral NAC. The sensitivity analysis performed demonstrated that an increase or a decrease by 5 to 10% in change of cost does not affect our final conclusion. Conclusion: The cost of treatment of IV NAC is lower due to shorter LOS of patients treated with IV NAC (p<0.001). However, when an extended course of treatment is medically necessary for patients on IV NAC then the cost of treatment with IV NAC exceeds the cost of treatment with oral NAC.

Heavy metal (HM) containing quantum dots (Qdots) are increasingly used in commercial products due to their unique electronic, optoelectronic, optical and magnetic properties. Once disposed to the landfill, environmental weathering is likely to compromise HM Qdot integrity, leading to release of heavy metal ions. To minimize any negative environmental impact of HM Qdots, there is an increasing demand for developing HM free or environmentally-friendly surface modified HM Qdot alternatives. In this study, synthesis of HM free ZnS:Mn/ZnS and surface modified HM CdS:Mn/ZnS Qdots (using N-acetylcysteine, NAC, and Dihydrolipoic acid, DHLA) and their potential toxicity assessment using E. coli as a model system is reported. NAC and DHLA are known antioxidants and therefore expected to reduce HM induced toxicity and improve colloidal stability of Qdots. All Qdots were synthesized at room temperature using a reverse micelle microemulsion method. Qdots were fully characterized using UV-visible absorption spectroscopy, fluorescence emission spectroscopy, zeta potential, Nuclear Magnetic Resonance spectroscopy (NMR) and High Resolution Transmission Electron Microscopy (HRTEM). Qdot environmental weathering was simulated by treating Qdots with concentrated acid (6N HCl). Qdot toxicity was evaluated on E. coli growth and viability using growth curves, turbidity and bactericidal assays (CFU). Results show that Zn based Qdots exhibit reduced toxicity on E.coli growth and viability when compared to Cd based Qdots. In addition, surface modification with NAC and DHLA minimized toxicity of Cd based Qdots. In summary, Zn based Qdots appear to be more environmental-friendly than Cd based Qdots

As Arabidopsis thaliana ages it becomes more resistant to virulent Pseudomonas syringae pv. tomato (Pst) bacteria. This is known as age-related resistance (ARR). ARR is associated with flowering and intercellular accumulation of salicylic acid (SA). A microarray experiment identified a number of jasmonic acid/ethylene (JA/ET)-associated genes whose expression was up-regulated during ARR. This thesis explores the role of JA/ET signaling during ARR by characterizing the role of two JA/ET-associated No Apical Meristem Cup-shaped Cotyledons (NAC) transcription factors: ANAC055 and ANAC092. Analysis of nae single and double mutants suggests that the NACs play nonredundant roles during ARR. The partial ARR defect of anac092 is followed one week later by an enhanced ARR response, and this is associated with a delay in flowering. Furthermore, mature 35S:ANAC092 exhibits increased susceptibility to Pst. Collectively, this data suggests that ANAC092 is a negative regulator of ARR and it contributes to positive regulation of flowering and the onset of ARR. The late flowering mutant luminidependens1 also exhibits a partial ARR defect, suggesting that the autonomous flowering pathway contributes to ARR. Gene expression data suggests that ANAC055 and ANAC092 regulate expression of some JA/ET-associated genes during ARR. The JA/ET signaling mutant ethylene insensitive2 (ein2) exhibits a partial ARR defect and reduced expression of ANAC055 and ANAC092, suggesting that EIN2 is a positive regulator of expression of ANAC055 and ANAC092 during ARR. Phytohormone analyses reveal that JA accumulates to similar levels in young and mature wild-type plants after inoculation with Pst, suggesting that increased expression of some JA/ET-associated genes in mature compared to young plants after inoculation with Pst is not associated with elevated levels of JA. This thesis contributes to our understanding of ARR by identifying some components of the NAC pathway, exploring the relationship between flowering and ARR, and conducting some phytohormone analysis. / Thesis / Doctor of Philosophy (PhD)

The mutualistic associations between Arbuscular mycorrhizal (AM) fungi and plant roots are ancient and ubiquitous across the plant kingdom, where AM fungi provide Phosphorus, Nitrogen, and water to the plant, and receive photosynthetically fixed Carbon in the form of fatty acids and sugars in return. Moreover, AM fungi are associated with increased plant resistance to both abiotic and biotic stressors such as drought and viral pathogens. Frequently used in agriculture, AM fungi are observed to increase crop yields and decrease chemical fertilizer needs for many economically important plant species. The potential to increase AM fungal effectiveness remains a driving force for current research. To determine their role in establishing and/or supporting AM symbiosis, we propose a reverse genetic study of two genes in the model legume Medicago truncatula. Based on RNA sequencing data indicating increased expression during AM symbiosis, we selected one gene that encodes for NAC TF-like protein, which belongs to a large family of plant transcription factors primarily involved in regulating the secretion of defence hormones. The second gene selected, PALM1, was recently discovered to play a role in the regulation of the trifoliate leaf structure of M. truncatula. We hypothesize that the genes under study play mechanistic roles in regulating AM fungal symbiosis and that we will observe a difference between the colonization rates of corresponding gene mutants and control groups. Firstly, we explored the involvement of the PALM1 and NAC TF genes by examining the root developmental phenotype of Medicago truncatula mutants. Secondly, we employed symbiosis assays to investigate the colonization rates of the genes in question. Results indicated that the NAC TF gene had no consistent role in the AM symbiosis, while the PALM1 gene revealed promising results, where significant increases in colonization rates were observed in PALM1 mutants throughout repeated experiments. Future research involves using this study to help pursue more effective ways to use AM fungi symbiosis in sustainable agro ecosystems.