161 |
Optical properties of living organismsZhou, Yuming January 2000 (has links)
No description available.
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162 |
Joint implementation in the Framework Convention on Climate Change and the Second Sulphur Protocol : an empirical and institutional analysisRidley, Michael Antony January 1997 (has links)
No description available.
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163 |
X-ray evolution and variability of active galactic nucleiPage, Mathew James January 1997 (has links)
No description available.
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164 |
Analysis of new engine cycles for spark ignition enginesCalnan, Peter John Courtney Benedict January 1998 (has links)
No description available.
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165 |
Angular and mass resolved energy distribution measurements with a gallium liquid metal ion sourceMarriott, P. January 1987 (has links)
No description available.
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166 |
Chemical properties and optical properties of carbonaceous particlesPapapanayotou, I. January 1988 (has links)
No description available.
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167 |
Modelling of ultrasonic transduction and measurement using finite elementsForsyth, Simon Andrew January 2000 (has links)
No description available.
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168 |
Cu-ZSM-5 zeolite catalysts for the selective catalytic reduction of NOxConnerton, Jan January 1999 (has links)
No description available.
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169 |
The theory of pre-equilibrium processes in nuclear reactionsChadwick, Mark Benjamin January 1989 (has links)
No description available.
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170 |
The development of targeted TiO2 nanoparticles for the detection of trastuzumab responsive breast tumours by positron emission tomographyCheyne, Richard William January 2011 (has links)
Screening of breast cancer patients for their tumour's prognostic marker status is necessary in determining the most suitable course of treatment. This is particularly important in the assessment of HER-2 expression status in identifying candidates who may respond to trastuzumab therapy. Current methods are limited in their effectiveness in accurately determining actual marker status.Discussed herein is an investigation into the development of a titanium dioxide nanoparticle system which may be applied as a medical imaging methodology through the use of positron emission tomography to gauge accurately a patient's HER-2 expression status in identifying candidates for trastuzumab therapy. The initial synthesis of organically coated ultra-small titanium dioxide nanoparticles is discussed in depth with respect to a range of coating molecules and further functionalisation. Additionally, methodology to elicit an exchange of these coat molecules is explored in detail resulting in the generation of TiO2 nanoparticles capable of forming long-term stable suspensions in water. An exploration of the synthesis of fluoride accepting groups for use in generating radiolabelled compounds is explored both successfully and unsuccessfully leading to the development of conditions suitable for radiolabelling aryltrifluoroborate compounds. Attempts to then combine these radionuclide accepting groups with biologically compatible TiO2 nanoparticles are discussed as an initial step toward the generation of a potential PET tracer. However, while this conjugation was achieved, a successful demonstration of the radiolabelling was not achieved requiring further focus on modulating the nanoparticle to easily allow its recovery from such reactions. Finally, an investigation into the effects of trastuzumab and cetuximab on FDG uptake by cells in vitro is discussed with respect to the potential of monitoring disease response to these drugs with conventional FDG-PET.
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