Submitted in partial fulfillment of the requirements for the Degree in Masters of Technology in Chiropractic, Department of Chiropractic and Somatology, Durban University of Technology, Durban, South Africa, 2016. / Introduction: Evidence suggests that Indians are at a greater risk of developing chronic diseases due to their unhealthy diet and sedentary lifestyle. The increased emphasis placed on exercise and diet in preventative regimens is altering related mortality and morbidity. Physical activity plays a role in the prevention of coronary heart disease and other chronic diseases which occur at a higher rate in inactive people. Despite the need for exercise to improve health, no study has examined the exercise profile of Indians in KwaZulu-Natal, South Africa, their exercise patterns and motivations regarding exercise. Aim: This study determined the patterns of exercise participation by Indians residing in KwaZulu- Natal (KZN). Methodology: A quantitative, descriptive, cross sectional survey was used in this study. The study was conducted at the Durban North Beach on selected weekends during August and September 2015. The target population was South African Indians. A convenience sample was used, that is, potential participants, who were at North Beach on the data collection days were approached with a request to participate in the study. Following the signing of an informed consent form, data was collected by means of a self-administered questionnaire. A total of 450 self-administered questionnaires were handed out and 411 completed questionnaires were received. Descriptive statistics in the form of frequencies, means and standard deviations were calculated. Relationships between two variables were determined using chi-squared tests, Fisher’s Exact test, Pearson’s correlation test, as appropriate. Odds ratios were calculated where relevant. A p value less than 0.05 was considered statistically significant. Results: The mean age of respondents was 37.7 ± 13.7 years. The majority (70.1%) participants reported that they currently exercise. However, only 42.9% of the respondents were found to meet the international requirement of 150 minutes of physical activity per week. When unstructured physical activity, such as household and yard chores were added, the latter frequency increased to 45.3%. Physical activity levels were similar across all age groups, likewise, similar proportions of males and females exercised. The most common exercises performed included walking (45.5%) and jogging (25.3%). Gymnasiums (33.5%), public grounds (25.3%) and the beachfront (21.4%) were the most commonly used locations for physical activity. One third of these respondents reported their health conditions as their main reason for exercising and most were aware about the value of exercise. Respondents who did not exercise regularly cited time management for their lack of exercise. Conclusion: The prevalence of exercise among South African Indians is low, with less than half of the population being physically active. Interventions are required to make people aware of the benefits of physical activity in order to increase the prevalence of exercise in this population. / M

Thesis (MSc)--University of Stellenbosch, 2008. / ENGLISH ABSTRACT: Iron metabolism disorders comprise the most common disorders in humans. Hereditary haemochromatosis (HH) is a common condition resulting from inappropriate iron absorption. The most common form of the disease (Type 1) is associated with mutations in the HFE gene. The C282Y homozygous genotype accounts for approximately 80% of all reported cases of HH within the Caucasian population. A second HFE mutation, H63D, is associated with less severe disease expression. The C282Y mutation is extremely rare in Asian and African populations. The H63D mutation is more prevalent and has been observed in almost all populations. Iron overload resulting from haemochromatosis is predicted to be rare in Asian Indian populations and is not associated with common HFE mutations that are responsible for HH in the Caucasian population. The aberrant genes associated with HH in India have not yet been identified. The present study attempted to identify variants in six iron regulatory genes that were resulting in the Type 1 HH phenotype observed in two Asian Indian probands from a highly consanguineous family. The promoter and coding regions of the HMOX1, HFE, HAMP, SLC40A1, CYBRD1 and HJV genes were subjected to mutation analysis. Gene fragments were amplified employing the polymerase chain reaction (PCR) and subsequently subjected to heteroduplex single-strand conformational polymorphism (HEX-SSCP) analysis. Samples displaying aberrations were then analysed using bi-directional semi-automated DNA sequencing analysis to identify any known or novel variants within the six genes. Variants disrupting restriction enzyme recognition sites were genotyped employing restriction fragment length polymorphism (RFLP) analysis. Mutation analysis of the six genes revealed 24 previously identified variants, five novel variants (HFE: 5’UTR-840T→G, CYBRD1: 5’UTR-1813C→T, 5’UTR-1452T→C, 5’UTR- 1272T→C; HJV: 5’UTR-534G→T, 5’UTR-530G→T), one previously described microsatellite and two novel repeats. Variants identified within the SLC40A1, CYBRD1 and HJV genes do not seem to be associated with the iron overload phenotype. A previously described HAMP variant (5’UTR-335G→T) was observed in the homozygous state in both probands. This variant seems to be the genetic aberration responsible for iron overload in this Indian family. The severe juvenile haemochromatosis phenotype usually associated with HAMP mutations, was not exhibited by the two Indian probands. Their symptoms resembled those observed in classic Type 1 HH. It is suggested that variants identified in the HMOX1 and HFE genes are modifying the effect of the HAMP variant and resulting in the less severe disease phenotype. Although this variant has only been identified in one Indian family, it could shed some light in the hunt for the iron-loading gene in India. / AFRIKAANSE OPSOMMING: Oorerflike hemochromatose (OH) is ‘n algemene siektetoestand wat ontstaan as gevolg van oneffektiewe opname van yster in die liggaam. Die mees algemene vorm van die siekte (Tipe 1) word geassosieer met mutasies in die HFE-geen. Die C282Y homosigotiese genotipe is verantwoordelik vir ongeveer 80% van alle gerapporteerde gevalle van OH binne die Kaukasiese bevolking. ‘n Tweede HFE mutasie, H63D, word geassosieer met minder ernstige siekte simptome. Die C282Y mutasie is besonder skaars in Asiese en Afrika bevolkings. Daar word bespiegel dat oorerflike ysteroorlading as gevolg van hemochromatose skaars is in Asiese Indiër bevolkings en word nie geassosieer met algemene HFE mutasies wat verantwoordelik is vir OH in Kaukasiese bevolkings nie. Die abnormale gene wat wél geassosieer word met OH in Indië is tot dusver nog nie identifiseer nie. Die doel van hierdie studie was om die variante in ses yster-regulerende gene te identifiseer wat die Tipe 1 OH fenotipe in hierdie familie veroorsaak. Hierdie fenotipe is waargeneem in twee Asies Indiese familielede afkomstig van ‘n bloedverwante familie. Die promotor en koderingsareas van die HMOX1, HFE, HAMP, SLC40A1, CYBRD1 en HJV gene is gesif vir mutasies. Geen fragmente is geamplifiseer met behulp van die polimerase kettingsreaksie (PKR) en daarna aan heterodupleks enkelstring konformasie polimorfisme (HEX-SSCP) analise blootgestel. PKR produkte wat variasies getoon het, is daarna geanaliseer deur tweerigting semi-geoutomatiseerde DNS volgorde-bepalingsanalise om enige bekende of nuwe variante binne die ses gene te identifiseer. Variante waar restriksie ensiem herkenningsetels teenwoordig is, is verder analiseer met behulp van die restriksie fragment lengte polimorfisme (RFLP) analise sisteem. Mutasie analise van die ses gene het 24 bekende variante, vyf nuwe variante (HFE: 5’UTR- 840T→G, CYBRD1: 5’UTR-1813C→T, 5’UTR-1452T→C, 5’UTR-1272T→C, HJV: 5’UTR-534G→T, 5’UTR-530G→T), een bekende herhaling en twee nuwe herhalings gewys. Variante wat binne die SLC4041, CYBRD1 en HJV gene geïdentifiseer is, blyk nie om by te dra tot die ysteroorladings-fenotipe nie. Die bekende HAMP variant (5’UTR-335G→T) is waargeneem in die homosigotiese toestand in beide van die aangetaste individue. Hierdie variant blyk om die genetiese fout te wees wat verantwoordelik is vir die ysteroorlading in die betrokke Indiese familie. Die erge juvenielehemochromatose fenotipe wat meestal geassosieer word met HAMP-mutasies, is nie waargeneem in hierdie familie nie. Hul simptome kom ooreen met die simptome van die klassieke Tipe 1 OH. Dit blyk moontlik te wees dat die variante identifiseer in die HMOX1 en HFE gene die impak van die HAMP variant modifiseer en die matiger siekte-fenotipe tot gevolg het. Alhoewel hierdie variant slegs in een Indiese familie geïdentifiseer is, kan dit lig werp op die soektog na die veroorsakende ysterladingsgeen in Indië.

Thesis (M.Tech.: Radiography)-Dept. of Radiography, Durban University of Technology, 2008. xxi, 146 leaves, Appendices A-S / The main aim of this study, was to assess the prevalence of coronary artery calcification in asymptomatic risk and non risk individuals in the South African Indian population, within the age group of 20-70 years.

Thesis submitted in fulfilment of the requirements of the Master's Degree in technology: Radiography, Durban University of Technology, 2008. / The main aim of this study, was to assess the prevalence of coronary artery calcification in asymptomatic risk and non risk individuals in the South African Indian population, within the age group of 20-70 years. / M

The purpose of this study was to describe the prevalence of increasing coronary heart diseases (CHD) among the Indian population in Chatsworth, Kwa Zulu-Natal. A quantitative, descriptive survey was conducted using non-probability purposive sampling. Respondents were sampled from four medical wards at the RK Khan Hospital. The results of this study indicate that the Indian population is at risk for the development of CHD. Although the increasing rate could not be attributed to a single risk factor, 72% of the respondents had a familial history of CHD and 52% had both parents at risk of CHD. Implementation of the primary prevention programmes recommended by the American Heart Association might reduce the prevalence among the Indian population. / Health Studies / M.A. (Health Studies)

The purpose of this study was to describe the prevalence of increasing coronary heart diseases (CHD) among the Indian population in Chatsworth, Kwa Zulu-Natal. A quantitative, descriptive survey was conducted using non-probability purposive sampling. Respondents were sampled from four medical wards at the RK Khan Hospital. The results of this study indicate that the Indian population is at risk for the development of CHD. Although the increasing rate could not be attributed to a single risk factor, 72% of the respondents had a familial history of CHD and 52% had both parents at risk of CHD. Implementation of the primary prevention programmes recommended by the American Heart Association might reduce the prevalence among the Indian population. / Health Studies / M.A. (Health Studies)