Global ETD Search

1	Quantum dots-amplified electrochemical cytochrome P450 phenotype sensor for tamoxifen, a breast cancer drug Feleni, Usisipho January 2017 (has links) Philosophiae Doctor - PhD / Breast cancer is regarded as the most common cancer in South Africa and its rate of occurrence is increasing. About one in every 31 South African women are at the risk of developing breast cancer and early diagnosis and treatment guarantee 90% survival rate. Tamoxifen is the drugs of choice for the treatment of all stages of breast cancer. The drug binds with estrogen receptor (ER) to minimize the transcription of estrogen dependent genes. However, nearly 50% of ER-positive breast cancer patients either become resistant or fail to respond to tamoxifen resulting in a serious clinical challenge in breast cancer management. The Grand Health Challenges of South Africa includes the development of cost effective diagnostic systems suitable for early detection of diseases and drug resistivity for timely invention and better patient management. / 2020-08-31 Breast cancer Capping agents Cyclic voltammetry (CV) Cytochrome P450 enzymes Differential pulse voltammetry (DPV) Electrochemical phenotype sensors Indinavir Limit of detection (LOD) Palladium telluride Quantum dots Square wave voltammetry (SWV) Tamoxifen