<p>Selective serotonin re-uptake inhibitors (SSRIs) are a new class of antidepressants used mainly for the treatment of depression and other forms of related disorders. There are a number of side effects associated with these drugs which include loss of weight, sexual dysfunction, nervousness and nausea. A fast and reliable detection method such as biosensing for the determination of the SSRIs metabolic profile is therefore essential for the appropriate dosing of these drugs. Biosensors for the determination of the SSRIs biotransformation were prepared with cytochrome P450 (2D6) isoenzyme and poly (anilinonapthalene sulfonic acid) film electrochemically deposited on gold.</p>

Thesis (PhD)--University of South Australia, 2001.

No description available.

No description available.

No description available.

No description available.

Nickel matte is a nickel &de concentrate produced by smelting. It consists mainly of two components: a nickel-copper alloy and heazlewoodite (Ni3S2); but also contains varying amounts of djurleite,Cu 1.96 S.There are several hydrometallurgical routes for processing nickel matte. The most recent of these involves an oxidative leach in acid chloride or sulfate solution. Nickel is subsequently recovered fiom the leach solution by electrowinning or by hydrogen reduction. In the work described in this thesis, various aspects of the acid leaching of nickel matte are investigated using mostly electrochemical methods. The first section concerns the use of copper(II) as an oxidant for the alloy component of nickel matte. In this cementation reaction, nickel goes into solution while copper is deposited on the dissolving metal swf8ce. The same reaction is important in removing traces of copper present in the nickel solution. Here nickel powder is added to the process liquor. A survey of the literature pertaining to the cementation of copper by nickel shows that there is considerable dispute as to the conditions under which cementation takes place. Evans' diagrams for the cementation reaction were constructed by superimposing the polarisation curves for the oxidation of nickel and the reduction of copper. It was found that cementation occurred provided that the two polarisation curves intersected in the region of active nickel dissolution. Outside this region, a copper deposit could not be seen. The second part of the thesis presents some investigations into the electrochemistry of nickel sulfides and nickel matte, and compares both chloride and sulfate media. Oxidation and dissolution rates of nickel matte powders using copper(I1) as an oxidant were also carried out. Dissolution was chemically controlled and so the rate was very dependent upon temperature and solution potential. Displacement of copper(II) from solution to form copper sulfide was also found to be important. In addition to the above studies, which relate directly to the oxidative leaching ofnickel matte, an investigation of the oxidation of HzS to sulfUr in acidic solution was carried out. S u k deposition was found to be strongly dependent on substrate and pH. Under some conditions, two types of sulfUr were deposited, with the more crystalline s u k being reduced at the more negative potential.

Thesis (Ph. D.)--State University of New York at Binghamton, Department of Chemistry, 2007. / Includes bibliographical references.

Thesis (Ph. D.)--Murdoch University, 1998. / Thesis submitted to the Division of Science. Includes bibliographical references (leaves 234-248).

Thesis (Ph. D.)--Michigan State University. Dept. of Chemistry, 2006. / Alpha in title represented by the lower case Greek letter. Title from PDF t.p. (viewed on Nov. 20, 2008) Includes bibliographical references (p. 235-245). Also issued in print.