Thesis (Ph. D.)--Florida State University, 2004. / Advisor: Dr. Andrew Dzurik, Florida State University, College of Engineering, Dept. of Civil and Environmental Engineering. Title and description from dissertation home page (viewed July 12, 2004). Includes bibliographical references.

Thesis (Ph.D.)--Washington State University, December 2005. / Includes bibliographical references (p. 143-155).

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 221-228).

Thesis (M.S.)--Brigham Young University. Dept. of Mechanical Engineering, 2005. / Includes bibliographical references (p. 91-94).

An apparatus is described that can determine electrophoretic mobilities of polar and non-polar colloidal dispersions down to -12 2 10 msV -1 -1 with typical resolutions of 0.5 to 5%, depending on the nature of the dispersion being studied. The diffusion coefficient and settling/convection velocity of the sample may be determined simultaneously in real time with the electrophoretic mobility. The technique, phase analysis light scattering (PALSY, is based upon classical laser-Doppler electrophoresis, but employs signal processing of the time domain phase information within the scattered light signal, rather than analysis of its frequency spectrum. This allows much smaller electric field strengths to be employed, thereby alleviating the usual heating problems associated with electrophoretic studies of non-polar dispersions. PALS measurements of typical aqueous latex dispersions with large mobilities and non-polar dispersions with very small mobilities (down to 5x 10_12 m2 s-1 V-1) are presented to illustrate the versatility of the technique.

This research investigates the effect of ionic charge and size on the mobility of specific metal ionic species in sandy soil under an electric field. During Phase-I experiments, three ions: lithium, lead and, aluminum were initially selected for study. Since the resistance of the cell varied with time, power could not be maintained constant. Therefore, a numerical integration technique was adopted to compare the results. These results show that the mobility of the ions increased with the increase in valence of the ions (for lithium and lead). However, aluminum interacted with and adsorbed to sand. To overcome this problem, aluminum spiked sand was used for Phase-II testing. During this phase, lithium, lead, and yttrium ions were evaluated. These results suggest that the mobility of the ions increased with increase in valence of the ions (Y > Pb >Li). However, ionic size did not have a substantial effect on the ionic movement.

abstract: Microfluidic systems have gained popularity in the last two decades for their potential applications in manipulating micro- and nano- particulates of interest. Several different microfluidics devices have been built capable of rapidly probing, sorting, and trapping analytes of interest. Microfluidics can be combined with separation science to address challenges of obtaining a concentrated and pure distinct analyte from mixtures of increasingly similar entities. Many of these techniques have been developed to assess biological analytes of interest; one of which is dielectrophoresis (DEP), a force which acts on polarizable analytes in the presence of a non-uniform electric fields. This method can achieve high resolution separations with the unique attribute of concentrating, rather than diluting, analytes upon separation. Studies utilizing DEP have manipulated a wide range of analytes including various cell types, proteins, DNA, and viruses. These analytes range from approximately 50 nm to 1 µm in size. Many of the currently-utilized techniques for assessing these analytes are time intensive, cost prohibitive, and require specialized equipment and technical skills. The work presented in this dissertation focuses on developing and utilizing insulator-based dielectrophoresis (iDEP) to probe a wide range of analytes; where the intrinsic properties of an analyte will determine its behavior in a microchannel. This is based on the analyte’s interactions with the electrokinetic and dielectrophoretic forces present. Novel applications of this technique to probe the biophysical difference(s) between serovars of the foodborne pathogen, Listeria monocytogenes, and surface modified Escherichia coli, are investigated. Both of these applications demonstrate the capabilities of iDEP to achieve high resolution separations and probe slight changes in the biophysical properties of an analyte of interest. To improve upon existing iDEP strategies a novel insulator design which streamlines analytes in an iDEP device while still achieving the desirable forces for separation is developed, fabricated, and tested. Finally, pioneering work to develop an iDEP device capable of manipulating larger analytes, which range in size 10-250 µm, is presented. / Dissertation/Thesis / Doctoral Dissertation Chemistry 2018

Thesis (M.S.)--Rutgers University, 2009. / "Graduate Program in Mechanical and Aerospace Engineering." Includes bibliographical references (p. 78-81).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1966. / Vita. Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Submitted in fulfillment of the requirements of the degree of Master of Applied Science in Chemistry, Durban University of Technology, 2015. / Human Serum Albumin (HSA) predominantly found in the blood plasma proteins, acts as a carrier for many drugs. In the present work binding interactions of eight arylpropionate non-steroidal anti-inflammatory drugs (NSAIDs) were studied with Human Serum Albumin HSA using Capillary Electrophoresis (CE) under physiological conditions. The concentration of HSA was kept constant (525 μM) whereas the drug concentrations were varied between 50-300 μM in each case. The Frontal analysis (FA) and Capillary Zone Electrophoresis (CZE) modes of CE were applied together with a mathematical modelling of the experimental results with a view to obtaining pharmacokinetic properties of each drug. The binding order of the drugs to HSA were established with the three methods together with the mathematical approach. Our studies revealed the presence of more than one binding sites for some of the available drugs. Additionally, molecular docking studies were conducted to establish the binding conformations of drugs in the binding pocket of the HSA. A very good correlation between the computed binding energies (docking) and the experimental binding constants were observed throughout this study. The logK values for all eight drugs were ranging from 3.37 - 4.56 for FA, 3.16 – 4.39 for CZE, and 3.48 – 5.30 for computational studies. / M