Economic preferences are crucial in decision making. While some preferences remain stable, changes in economic preferences have been linked to institutional and policy changes. We conduct three studies to explore the ways in which decision making might be impacted by economic preferences and underlying or changing policies. Our studies span the domains of preventative healthcare, strategic interactions, and education. Chapter 2 examines the relationship between cooperative decision making and changes in societal level institutions through a meta-meta analysis, incorporating experimental data from various previously conducted meta-analyses. We study the relationship between country or region level policy changes, as measured by economic freedom indices to experimental measures of prosocial and selfish behavior. Our results indicate a relationship between macro-level institutional changes and measures of co-operative behavior that varies based on the starting levels of economic freedom variables. This establishes a relationship between macro policies and individual behavior that suggests that governments should consider the consequences of policies on individual decision making. Chapter 3, using vignette experiments, explores how emotion reappraisal messaging interventions affect betrayal aversion and vaccine hesitancy. The measure of betrayal aversion in our study involves hesitancy in risking being betrayed in situations involving trust related to vaccines. We find that betrayal aversion is prevalent in about a third of our study participants and that two of our messaging interventions substantially reduce betrayal aversion involving vaccination decisions. Our results suggests a targeted messaging strategy for addressing a recently discovered new component of vaccine hesitancy, an important current topic in preventative healthcare. Chapter 4, introduces an active learning intervention in the form of a field experiment involving a health intervention nudge and explores its impact on class engagement and education outcomes of students. In addition, we look at the impact of the nudge on vaccination uptake among students. We find improved class engagement as well as improvement in test scores for students who had the opportunity and chose to participate in the nudge experiment. In addition, we find greater uptake of influenza vaccination, as targeted by the nudge treatment. Our results show that this effect is driven by men, with women having higher vaccination rates irrespective of the nudge treatment. JEL codes: C91, H1, 01, P5, I12, D91, A22, C93 / Doctor of Philosophy / This dissertation explores how policy changes in our environment, interact with our preferences and affect decision making in social decision making, healthcare and education domains. We explore macro policies designed to create country-level institutional changes, involving the legal system, monetary policy, trade and labor policy, as well as examining two individual-level interventions including targeted messaging to improve vaccination uptake, and course performance in introductory economics. These wide variety of policy interventions give us a wide spectrum of decisions to study across different domains. Chapter 2 examines the relationship between policy changes at the macro-institutional level and aggregate cooperative decision making. In this study, we establish a relationship between baseline institutional structure and changes in cooperative behavior corresponding to changes in societal level institutions. Our results suggests that current and historic societal level institutional structures should be kept in mind when designing policies. Chapter 3 explores the effect of messaging treatments targeting emotions on uptake of vaccination using a vignette experiment. Here, we study the effects on a particular emotion, betrayal aversion, which in our study, involves hesitancy related to the risk of getting betrayed in the context of vaccination. Our results suggest that a targeted messaging strategy, might prove to be effective in designing policies to improve vaccination uptake. Chapter 4 explores the impact of an active learning approach on class engagement and education outcomes of students in introductory economics. Providing students the chance to participate in a field experiment designed as a vaccination nudge, we incorporate the active learning component of the course and study the impact of participation in this active learning module. Our results suggest improved engagement and education outcomes among students who had the opportunity to participate in the experiment. Our results also suggest that proximity nudges might prove to be effective in improving vaccination uptake. We demonstrate the importance of designing context-specific policies for them to be instrumental in bringing about targeted change. At the aggregate country level, we find that similar type of policy interventions when introduced in countries with differing baseline institutional structures might lead to different results. At the individual level, we find evidence that targeted interventions does shape decisions. We find that targeted health communications messaging can lead to improvement in health behavior. We also find that introducing active learning modules improves learning outcomes among students. Taken together, the findings in this dissertation demonstrates how both economic preferences and underlying policies are important factors in decision making.