U-statistics generalizes the concept of mean of independent identically distributed (i.i.d.) random variables and is widely utilized in many estimating and testing problems. The standard empirical likelihood (EL) for U-statistics is computationally expensive because of its onlinear constraint. The jackknife empirical likelihood method largely relieves computation burden by circumventing the construction of the nonlinear constraint. In this thesis, we adopt a new jackknife empirical likelihood method to make inference for the general volume under the ROC surface (VUS), which is one typical kind of U-statistics. Monte Carlo simulations are conducted to show that the EL confidence intervals perform well in terms of the coverage probability and average length for various sample sizes.

The empirical likelihood method introduced by Owen (1988, 1990) is a powerful nonparametric method for statistical inference. It has been one of the most researched methods in statistics in the last twenty-five years and remains to be a very active area of research today. There is now a large body of literature on empirical likelihood method which covers its applications in many areas of statistics (Owen, 2001). One important problem affecting the empirical likelihood method is its poor accuracy, especially for small sample and/or high-dimension applications. The poor accuracy can be alleviated by using high-order empirical likelihood methods such as the Bartlett corrected empirical likelihood but it cannot be completely resolved by high-order asymptotic methods alone. Since the work of Tsao (2004), the impact of the convex hull constraint in the formulation of the empirical likelihood on the finite sample accuracy has been better understood, and methods have been developed to break this constraint in order to improve the accuracy. Three important methods along this direction are [1] the penalized empirical likelihood of Bartolucci (2007) and Lahiri and Mukhopadhyay (2012), [2] the adjusted empirical likelihood by Chen, Variyath and Abraham (2008), Emerson and Owen (2009), Liu and Chen (2010) and Chen and Huang (2012), and [3] the extended empirical likelihood of Tsao (2013) and Tsao and Wu (2013). The latter is particularly attractive in that it retains not only the asymptotic properties of the original empirical likelihood, but also its important geometric characteristics. In this thesis, we generalize the extended empirical likelihood of Tsao and Wu (2013) to handle inferences in two large classes of one-sample and two-sample problems. In Chapter 2, we generalize the extended empirical likelihood to handle inference for the large class of parameters defined by one-sample estimating equations, which includes the mean as a special case. In Chapters 3 and 4, we generalize the extended empirical likelihood to handle two-sample problems; in Chapter 3, we study the extended empirical likelihood for the difference between two p-dimensional means; in Chapter 4, we consider the extended empirical likelihood for the difference between two p-dimensional parameters defined by estimating equations. In all cases, we give both the first- and second-order extended empirical likelihood methods and compare these methods with existing methods. Technically, the two-sample mean problem in Chapter 3 is a special case of the general two-sample problem in Chapter 4. We single out the mean case to form Chapter 3 not only because it is a standalone published work, but also because it naturally leads up to the more difficult two-sample estimating equations problem in Chapter 4. We note that Chapter 2 is the published paper Tsao and Wu (2014); Chapter 3 is the published paper Wu and Tsao (2014). To comply with the University of Victoria policy regarding the use of published work for thesis and in accordance with copyright agreements between authors and journal publishers, details of these published work are acknowledged at the beginning of these chapters. Chapter 4 is another joint paper Tsao and Wu (2015) which has been submitted for publication. / Graduate / 0463 / fwu@uvic.ca

The existing estimation techniques for grouped data models can be analyzed as a class of estimators of instrumental variable-Generalized Method of Moments (GMM) type with the matrix of group indicators being the set of instruments. Econometric literature (e.g. Smith, 1997; Newey and Smith, 2004) show that, in some cases of empirical relevance, GMM can have shortcomings in terms of the large sample behaviour of the estimator being different from the finite sample properties. Generalized Empirical Likelihood (GEL) estimators are developed that are not sensitive to the nature and number of instruments and possess improved finite sample properties compared to GMM estimators. In this thesis, with the assumption that the data vector is iid within a group, but inid across groups, we developed GEL estimators for grouped data model having population moment conditions of zero mean of errors in each group. First order asymptotic analysis of the estimators show that they are √N consistent (N being the sample size) and normally distributed. The thesis explores second order bias properties that demonstrate sources of bias and differences between choices of GEL estimators. Specifically, the second order bias depends on the third moments of the group errors and correlation among the group errors and explanatory variables. With symmetric errors and no endogeneity all three estimators Empirical Likelihood (EL), Exponential Tilting (ET) and Continuous Updating Estimator (CUE) yield unbiased estimators. A detailed simulation exercise is performed to test comparative performance of the EL, ET and their bias corrected estimators to the standard 2SLS/GMM estimators. Simulation results reveal that while, with a few strong instruments, we can simply use 2SLS/GMM estimators, in case of many and/or weak instruments, increased degree of endogeneity, or varied signal to noise ratio, bias corrected EL, ET estimators dominate in terms of both least bias and accurate coverage proportions of asymptotic confidence intervals even for a considerably large sample. The thesis includes a case where there are within group dependent data, to assess the consequences of a key assumption being violated, namely the within-group iid assumption. Theoretical analysis and simulation results show that ignoring this feature can result in misleading inference. The proposed estimators are used to estimate the returns to an additional year of schooling in the UK using Labour Force Survey data over 1997-2009. Pooling the 13 years data yields roughly the same estimate of 11.27% return for British-born men aged 25-50 using any of the estimation techniques. In contrast using 2009 LFS data only, for a relatively small sample and many weak instruments, the return to first degree holder men is 13.88% using EL bias corrected estimator, where 2SLS estimator yields an estimate of 6.8%.

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In this dissertation, we investigate jackknife empirical likelihood methods motivated by recent statistics research and other related fields. Computational intensity of empirical likelihood can be significantly reduced by using jackknife empirical likelihood methods without losing computational accuracy and stability. We demonstrate that proposed jackknife empirical likelihood methods are able to handle several challenging and open problems in terms of elegant asymptotic properties and accurate simulation result in finite samples. These interesting problems include ROC curves with missing data, the difference of two ROC curves in two dimensional correlated data, a novel inference for the partial AUC and the difference of two quantiles with one or two samples. In addition, empirical likelihood methodology can be successfully applied to the linear transformation model using adjusted estimation equations. The comprehensive simulation studies on coverage probabilities and average lengths for those topics demonstrate the proposed jackknife empirical likelihood methods have a good performance in finite samples under various settings. Moreover, some related and attractive real problems are studied to support our conclusions. In the end, we provide an extensive discussion about some interesting and feasible ideas based on our jackknife EL procedures for future studies.

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In medical diagnostic studies, the area under the Receiver Operating Characteristic (ROC) curve (AUC) and Youden index are two summary measures widely used in the evaluation of the diagnostic accuracy of a medical test with continuous test results. The first half of this dissertation will highlight ROC analysis including extension of Youden index to the partial Youden index as well as novel confidence interval estimation for AUC and Youden index in the presence of covariates in induced linear regression models. Extensive simulation results show that the proposed methods perform well with small to moderate sized samples. In addition, some real examples will be presented to illustrate the methods. The latter half focuses on the application of empirical likelihood method in economics and finance. Two models draw our attention. The first one is the predictive regression model with independent and identically distributed errors. Some uniform tests have been proposed in the literature without distinguishing whether the predicting variable is stationary or nearly integrated. Here, we extend the empirical likelihood methods in Zhu, Cai and Peng (2014) with independent errors to the case of an AR error process. The proposed new tests do not need to know whether the predicting variable is stationary or nearly integrated, and whether it has a finite variance or an infinite variance. Another model we considered is a GARCH(1,1) sequence or an AR(1) model with ARCH(1) errors. It is known that the observations have a heavy tail and the tail index is determined by an estimating equation. Therefore, one can estimate the tail index by solving the estimating equation with unknown parameters replaced by Quasi Maximum Likelihood Estimation (QMLE), and profile empirical likelihood method can be employed to effectively construct a confidence interval for the tail index. However, this requires that the errors of such a model have at least finite fourth moment to ensure asymptotic normality with n1/2 rate of convergence and Wilk's Theorem. We show that the finite fourth moment can be relaxed by employing some Least Absolute Deviations Estimate (LADE) instead of QMLE for the unknown parameters by noting that the estimating equation for determining the tail index is invariant to a scale transformation of the underlying model. Furthermore, the proposed tail index estimators have a normal limit with n1/2 rate of convergence under minimal moment condition, which may have an infinite fourth moment, and Wilk's theorem holds for the proposed profile empirical likelihood methods. Hence a confidence interval for the tail index can be obtained without estimating any additional quantities such as asymptotic variance.