Applying the maximum principle of optimal control that is widely used in the theories of endogenous growth to the decentralized market, this project will study how, under the consideration of transaction costs, producers and consumers choose the optimal degree of production roundaboutness and determine the growth rate of the economy. The purposes of the project can be viewed from two respects: 1. From the view point of growth theory, the project studies how the combined effect of production widening, i.e. learning by doing effect caused by social production capacity, and production deepening, i.e. economies of division of labor caused by higher degree of production roundaboutness, improve the productivity of production and thus create the possibility of permanent growth. 2. The project also emphasizes the important role of transaction costs, as the new institutionalism having highlighted, in the determination of optimal production roundaboutness, in contrast to that tradition concentrating how the organization from for transaction is chosen. We shall start with an one-sector model in which the knowledge of production is available freely, and show that the optimal degree of production roundaboutness depends on the rate of transaction cost. Next, in an extended two-sector model in which the technology of roundabout production can be invented only through investing scarce resource, we shall demonstrate how the path of transitional dynamics leads the economy to its steady state that reveals permanent growth.

Thesis (Ph. D.)--University of Chicago, Dept. of Economics, June 2001. / Includes bibliographical references. Also available on the Internet.

The costs of acquiring parcels by condemnation are usually significantly higher than those for property acquired by negotiation, suggesting that Right-of-Way (R/W) acquisition costs may best be described by two different regression equations. This paper develops a switching regression model of acquisition cost to simultaneously predict the probability of whether a parcel will go to condemnation rather than be acquired via negotiation and the corresponding acquisition costs under these two regimes. The error terms of the selection equation and the two cost equations follow a trivariate normal distribution to reflect correlations across unobserved factors (such as a land owner's tenacity or a site's view value). When this model is calibrated using data on properties acquired across the state of Texas for transportation projects between 2008 and 2011, results suggest that R/W appraisers and staff should pay special attention to commercially used parcels in urban areas involving a partial taking with a relatively small remainder. Comparison of cost estimates between the two regimes (condemnation vs. negotiation) suggests that condemned parcels will have, on average, 78% higher acquisition costs across the 1,710 acquired properties and 51% greater price variation. These results suggest that it is much more costly to acquire a property and more difficult to accurately predict its costs if it cannot be acquired via negotiation. The application of model estimates to an example corridor highlights the value of simulation to capture all modeling uncertainties. This two-regime model is further extended to a three-category multinomial endogenous switching, allowing for differential cost estimates across negotiation-deed, administrative settlement, and condemnation contexts. A model of acquisition time -- from the agency's initial-offer date to its final possession date is also developed, to examine the effects of condemnation on acquisition duration. The results suggest that condemnation proceedings add approximately 7 to 8 months, on average, to parcel acquisitions by the Texas Department of Transportation. Taken together, such switching models for condemnation versus negotiated settlement highlight the benefits of avoiding condemnation proceedings in R/W acquisition. Estimation results illuminate the relative importance of various parcel and owner attributes, impacting the nature and cost of acquisition, and enhancing opportunities for R/W staff to identify more contentious properties and establish more reliable budget estimates. / text

Exercise is often prescribed for patients with chronic pain, but there is little objective evidence supporting this recommendation. Therefore, we tested the effect of moderate aerobic exercise on the sensory hypersensitivity produced in an animal model of neuropathic pain. Male rats that underwent unilateral ligation of the L5 and L6 spinal nerves (SNL) were divided into exercise-trained or sedentary groups. Exercise training was performed using a treadmill, beginning 7 days after surgery, and continued 5 days a week for 5 weeks. Animals were exercised 30 min/day, at a speed of 14-16 m/min. Sensory testing was performed 23 hours after exercise training. Typical thermal and tactile hypersensitivity developed within 1 week after surgery. Treadmill training reversed thermal and tactile hypersensitivity in injured animals within 4 weeks, but had no effect on sham-operated or non-operated animals. One week after the cessation of exercise training, tactile hypersensitivity returned.The effects of exercise training on SNL-induced sensory hypersensitivity were reversed by the opioid receptor antagonist naloxone. Naloxone or naloxone methiodide reversed the effects of exercise when administered intracerebroventricularly (i.c.v.). Immunohistochemistry revealed increased immunostaining for B-endorphin and met-enkephalin in the periaquaductal grey (PAG) and rostral ventromedial medulla (RVM) regions of exercise-trained animals compared to sedentary animals. An ELISA immunoassay revealed a 31% increase in PAG B-endorphin content in exercise-trained SNL animals. More BDNF was also present in the brain's of exercise-trained animals compared to sedentary, specifically in the ventromedial hypothalamus, hippocampus, and outer rim of the PAG. Administering a BDNF sequestering agent reversed B-endorphin increases in the PAG of exercise-trained animals. Exercise-trained SNL animals treated with 25 ug BDNF sequestering agent (i.c.v.) had lower tactile thresholds compared to the exercise-trained vehicle group.These results support the recommendation of moderate aerobic exercise for patients suffering from neuropathic pain, and suggest that exercise-induced pain reversal results from the upregulation of endogenous opioids in the brainstem. Additionally, increased BDNF with exercise training may play a role in exercise-induced reversal of neuropathic pain by increasing the expression of endogenous opioids, but this needs to be verified further.

Three studies were conducted. In the first study, 12 Yorkshire barrows (initial BW of 23.2 ± 2.0 kg) were allotted to 2 dietary treatments with 6 replications per treatment using a completely randomized design to determine apparent Ca and P digestibility (AD), true digestibility (TD) and endogenous output (EO) in a corn/SBM-based diet. All pigs were placed in individual feeder pens that allowed for easy collection of individual feces. The AD of Ca and P were 28.4% and 23.9%, respectively. Their TD of 42% and 40% for Ca and P respectively were significantly (P < 0.05) higher than the corresponding AD. EO was 0.8g for Ca and 1.3g for P per kg of dry matter intake (DMI). In the second study, the optimal dietary ratio of true digestible Ca and P was determined in terms of its effect on growing pig performance, excretion of Ca and P in feces and urine in a corn/SBM-based diet using a randomized complete block design. Thirty six growing barrows (initial BW: 24.2 ± 1.9 kg) were allotted to 6 dietary treatments with 6 replications per block. Six corn/SBM-based diets with very similar nutrient contents were formulated but differed in their dietary ratio of Ca to P. The balances of Ca and P and their true digestibility/retention were calculated for each diet. Animal performance and true retention of both Ca and P was optimal (P < 0.05) with diet 2 with a true digestible Ca to P ratio of 0.82: 1 compared to other experimental diets. The third study was conducted with a similar protocol to that used in experiment 1 involving 12 barrows (initial BW: 23.9 ± 1.1 kg) to determine Mg, Cu, Fe, Mn, Se and Zn TD values for the growing pig. Se and Zn AD of 73.9% and 9.5% significantly (P < 0.05) underestimated their TD of 82.1% and 15%, respectively. Se and Zn EO were 0.00004mg and 0.01 mg/kg of DMI, respectively. The TD and EO for Mg, Cu, Fe and Mn could not be estimated because of their negative AD.

The focus here is on the log-normal version of the spatial interaction model. In this context, we consider spatial econometric specifications that can be used to accommodate two types of dependence scenarios, one involving endogenous interaction and the other exogenous interaction. These model specifications replace the conventional assumption of independence between origin-destination-flows with formal approaches that allow for two different types of spatial dependence in flow magnitudes. Endogenous interaction reflects situations where there is reaction to feedback regarding flow magnitudes from regions neighboring origin and destination regions. This type of interaction can be modeled using specifications proposed by LeSage and Pace (2008) who use spatial lags of the dependent variable to quantify the magnitude and extent of feedback effects, hence the term endogenous interaction. Exogenous interaction represents a situation where spillover arise from nearby (or perhaps even distant) regions, and these need to be taken into account when modeling observed variation in flows across the network of regions. In contrast to endogenous interaction, these contextual effects do not generate reaction to the spillovers, leading to a model specification that can be interpreted without considering changes in the long-run equilibrium state of the system of flows. We discuss issues pertaining to interpretation of estimates from these two types of model specification, and provide an empirical illustration. (authors' abstract)

No description available.

Diss. (sammanfattning) Uppsala : Univ., 2002. / Härtill 5 uppsatser.

Originally presented as the author's thesis (doctoral)--Helsinki School of Economics, 2004. / Includes bibliographical references (p. 71-76). Also available online.

Thesis (Ph. D.)--University of Washington, 1999. / Vita. Includes bibliographical references (leaves 110-115).