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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Immune and adjuvant IgG responses to Brucella lipopolysaccharide in mice

Kurtz, Robin S. January 1984 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1984. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
2

Effects of bacterial lipopolysaccharides and polyadenylic:polyuridylic acid on immune function

Lamb, Ruth E. January 1979 (has links)
Thesis (M.S.)--University of Wisconsin--Madison. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 72-82).
3

Determination of the presence of endotoxin within the mineralized tissues of apical root dentin a thesis submitted in partial fulfillment ... for the degree of Master of Science in Endodontics ... /

Allen, James Stevan. January 1993 (has links)
Thesis (M.S.)--University of Michigan, 1993. / Includes bibliographical references.
4

Expression profile, molecular regulation and immuno-inflammatory function of LPS-binding protein in human oral keratinocytes

Ding, Peihui., 丁佩惠. January 2012 (has links)
Lipopolysaccharide (LPS)-binding protein (LBP) functions as a crucial molecule in innate immune responses to bacterial challenge. Our recent study shows the expression of LBP in human gingiva and its significant association with periodontal condition. Porphyromonas gingivalis is a keystone periodontopathogen with its LPS as a major virulence factor strongly involved in periodontal pathogenesis. Recent study has discovered that P. gingivalis LPS displays a significant lipid A structural heterogeneity. The present study investigated i) the expression profile of LBP in human oral keratinocytes (HOKs) stimulated by P. gingivalis LPS with penta-acylated (LPS1690) and tetra- (LPS1435/1449) lipid A structures as well as E. coli LPS; ii) the involvement of toll-like receptors (TLRs) and downstream signaling mechanisms in LBP expression; and iii) the effects of LBP and its crosstalk with the two isoforms of P. gingivalis LPS on the expression of cytokines and human β-defensins (hBD-2) in HOKs. The expression of LBP mRNA and peptide was significantly up-regulated by P. gingivalis LPS1690 and E. coli LPS, while not by P. gingivalis LPS1435/1449. P. gingivalis LPS1690-induced LBP expression was through both TLR2 and TLR4, and the relevant down-stream signaling mechanisms were then further investigated. Western blot results showed that P. gingivalis LPS1690 activated the phosphorylation of IκBα, p65, p38 MAPK and SAPK/JNK, whereas E. coli LPS phosphorylated IκBα, p38 MAPK and SAPK/JNK. A nuclear translocation of NF-κB transcription factor was confirmed upon stimulation by both forms of LPS. Further blocking assay revealed that P. gingivalis LPS1690 induction of LBP was through NF-κB and p38 MPAK pathways, while E. coli LPS induction of LBP was mediated by NF-κB, p38 MPAK and JNK pathways. The effects of LBP and its crosstalk with P. gingivalis LPS1690 or LPS1435/1449 on the expression of cytokines and hBD-2 were further investigated. Interestingly, recombinant human LBP (rhLBP) per se could significantly up-regulate the expression of IL-6, IL-8 and TNF-α, while down-regulate hBD-2 expression. P. gingivalis LPS1690 or LPS1435/1449 modulated to different extents the rhLBP-induced cytokine expression. Notably, P. gingivalis LPS1690 significantly down-regulated rhLBP-induced IL-8 expression; whereas, P. gingivalis LPS1435/1449 down-regulated IL-8 expression more intensively (around 80% vs. 40% reduction). The key mediators of TLRs and their adaptors like CD180 and MD-1 were significantly down-regulated by rhLBP (fold changes: -2.44 and -9.62, respectively). Both CD180 and MD-1 mRNAs were up-regulated by P. gingivalis LPS1435/1449 (7.11 and 4.05 folds, respectively); while these two genes were reversely modulated by P. gingivalis LPS1690 (20.86 and -6.93 folds, respectively). The present study demonstrates that P. gingivalis LPS with a lipid A structural heterogeneity differentially modulates LBP expression in HOKs. P. gingivalis LPS1690 promotes LBP expression in HOKs through TLR2 and TLR4 as well as NF-κB and p38 MAPK pathways in a way different from E. coli LPS. rhLBP per se significantly up-regulates the expression of IL-6, IL-8 and TNF-α, while down-regulates hBD-2 expression. P. gingivalis LPS with different lipid A structures down-regulates to different extents the rhLBP-induced expression of cytokines in HOKs, likely through fine-tuning of the CD180-MD1 complex and the relevant TLRs. / published_or_final_version / Dentistry / Doctoral / Doctor of Philosophy
5

A study of endotoxins and mononuclear phagocytes with focus on B̲a̲c̲t̲e̲r̲i̲o̲d̲e̲s̲ i̲n̲t̲e̲r̲m̲e̲d̲i̲u̲s̲ endotoxin, its chemistry and biological effects /

Johne, Berit. January 1987 (has links)
Thesis--University of Oslo, Norway, 1987. / Includes bibliographical references.
6

A study of endotoxins and mononuclear phagocytes with focus on B̲a̲c̲t̲e̲r̲i̲o̲d̲e̲s̲ i̲n̲t̲e̲r̲m̲e̲d̲i̲u̲s̲ endotoxin, its chemistry and biological effects /

Johne, Berit. January 1987 (has links)
Thesis--University of Oslo, Norway, 1987. / Includes bibliographical references.
7

Effects of continous administration of low-dose of Escherichia coli lipopolysaccharide in chicks and poults fed non toxic doses of aflatoxin B1 and T-2 toxin

Guaiume, Elisângela Aparecida. January 2005 (has links)
Thesis (M.S.)--University of Missouri-Columbia, 2005. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (July 13, 2006) Includes bibliographical references.
8

Characterization of the endotoxin response in zebrafish, and synthesis of a snakehead rhabdovirus expressing red fluorescent or green fluorescent protein /

Giasson, Gregory M., January 2006 (has links) (PDF)
Thesis (M.S.) in Biochemistry--University of Maine, 2006. / Includes vita. Includes bibliographical references (leaves 65-74).
9

Characterization of the Endotoxin Response in Zebrafish, and Synthesis of a Snakehead Rhabdovirus Expressing Red Fluorescent or Green Fluorescent Protein

Giasson, Gregory M. January 2006 (has links) (PDF)
No description available.
10

Immunomodulatory roles of endotoxin and glutaraldehyde in the development of latex allergy

Howell, Michael D. January 1900 (has links)
Thesis (Ph. D.)--West Virginia University, 2002. / Title from document title page. Document formatted into pages; contains xvii, 194 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 163-181).

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