No description available.

No description available.

Treatment of thioanisole-substituted aryldiyne with 2 equiv. of N-Iodosuccinimide and 5 mol% of PPh3AuCl and 5 mol% AgSbF6 in refluxing dichloromethane gave 5-iodo benzo[b]naphtho[2,1-d]thiophene in good yields. This method tolerated various functional groups in alkyl and phenyl moiety. We also treatment thioanisole-substituted aryldiyne with 10 mo% of PdX2 and 3 equiv. CuX2 (X= Cl, Br),in reluxing THF gave in 5-position have halogen substitute benzo[b]naphtho[2,1-d]thiophene derivative.

Thesis (Ph. D.)--Florida State University, 2005. / Advisor: Igor V. Alabugin, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Jan. 25, 2006). Document formatted into pages; contains xvi, 346 pages. Includes bibliographical references.

Thesis (Ph.D)--Bowling Green State University, 2006. / Document formatted into pages; contains xv, 366 p. : ill. Includes bibliographical references.

Thesis (M.S.)--Florida State University, 2004. / Advisor: Dr. Igor Alabugin, Florida State University, College of Arts and Science, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Sept. 23, 2004). Includes bibliographical references.

Thesis (Ph. D.)--University of Oregon, 1999. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 162-172). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p9955913.

No description available.

Two diverse works regarding DNA-Drug Interaction are presented here. The first portion deals with covalent interactions between compounds that are derivatives of heterocyclic aza-enediynes and DNA (conventional Watson-Crick base paired double stranded DNA) and the second is related to non-covalent interactions of these compounds with G-quadruplex DNA. The aza-enediynes have been studied for their ability to undergo aza-variants of the Bergman and Myers cyclizations, and the potential role of the ensuing diradicals in DNA cleavage chemistry. The aza-Myers-Saito cyclization of aza-enyne allenes that are derived from base-promoted isomerization of skipped aza-enediynes has been recently reported. In the first part of the dissertation, the synthesis and DNA cleavage chemistry of a series of pyridinium skipped aza-enediynes (2-alkynyl-Npropargyl pyridine salts) are reported. Efficient DNA cleavage requires the presence of the skipped aza-enediyne functionality, and optimal DNA cleavage occurs at basic pH. An optimized analog containing a p-methoxyphenyl substituent was prepared. Studies with radiolabeled DNA duplexes reveal that this analog generates nonselective frank DNA strand breaks, via deoxyribosyl 4'-hydrogen atom abstraction, and also leads to oxidation of DNA guanine bases. This is the first report of enediynelike radical-based DNA cleavage by an agent designed to undergo an alternative diradical-generating cyclization. The second part is based upon the growing evidence for G-quadruplex DNA structures in genomic DNA and the presumed need to resolve these structures for replication. A prototypical replicative helicase - SV40 large T-antigen (T-ag), a multifunctional protein with duplex DNA helicase activity is shown to also unwind G-quadruplex DNA structures. A series of G-quadruplex-interactive agents, particularly perylene diimide derivatives, is explored for inhibition of T-ag duplex and G-quadruplex DNA unwinding activities, and it is revealed that certain perylene diimides are both potent and selective inhibitors of the G-quadruplex DNA helicase activity of T-ag. Surface plasmon resonance and fluorescence spectroscopic Gquadruplex DNA binding studies of these T-ag G-quadruplex helicase inhibitors have been carried out, demonstrating the importance of attributes in addition to binding affinity for G-quadruplex DNA that may be important for inhibition. The identification of potent and selective inhibitors of the G-quadruplex helicase activity of T-ag provides tools for probing the specific role of this activity in SV40 replication.

Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.