M.A. (Development Studies) / Informal cross-border trade is one of the viable informal sector activities which had become a key livelihood strategy for many Zimbabweans mainly during the time period of 2007 to 2009, at the height of the economic and political crisis in Zimbabwe. That was a period of intense shortages of basic commodities which have left the country depending mainly on donations and imports from neighbouring countries. The study sought to understand the experiences and coping strategies of Zimbabwean women informal cross-border traders operating between Gwanda/Bulawayo, Zimbabwe and Johannesburg/Gauteng, South Africa. The study followed the whole chain of trade with focus on experiences and coping strategies of traders at the various stages of informal trade. Semi-structured in-depth interviews and life history analysis were conducted with nine women traders and some informal discussions conducted with bus drivers, artists and other suppliers of goods. Observations were also made which included travelling with informal cross-border traders across the border, being with them when they bought their goods, and staying with them at one of the markets in South Africa where they sold curios they brought from Zimbabwe.The study noted that informal cross-border traders were mostly motivated by the desire to support their children and see them through school, including tertiary education. Their motivation was strong enough to keep them determined to stay in business despite the many challenges that they faced. These challenges included xenophobic attacks, police harassment, transport challenges, bad accommodation while away from home, visa challenges and many others. The coping strategies included finding ways of sharing costs, ‘cheating’ the system where some rules and regulations hindered their progress, and creating a strong social support base and connections. It was also noted that changing economic and political environment had direct impacts on the trade and hence flexibility of goods traded and medium of exchange are a crucial character of the trade in unstable environments.